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Using the 3D “brain-on-a-chip” platform, LLNL researchers were able to keep human-derived neurons alive, networked and communicating in a 3D gel, while non-invasively recording their electrical activity using Lab-developed, thin-film microelectrode arrays. The work continues LLNL’s exploration into chip-based in vitro devices capable of replicating human systems, including the heart, central nervous system (2D), the blood-brain barrier and peripheral nervous system.