Dr. Roger Detels will present opportunities realized that have contributed to advancing our understanding of disease pathogenesis as well as the shaping of public health policy and promoting of future public health leaders, both nationally and internationally. The Lester Breslow Distinguished Lecture was established in honor of the late Dr. Lester Breslow, a former dean and professor emeritus of the school and director of the California Public Health Department. A pillar of public health, Breslow was among the first to quantify the health benefits/risks and associations with life expectancy of exercise, diet, sleep, and smoking.