Changes in Mitochondrial DNA Control how Nuclear DNA Mutations Are Expressed in Cardiomyopathy

Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation. When combined with a nuclear DNA mutation in mice, one...
11-Sep-2018 1:45 PM EDT Add to Favorites

Novel Gene Mutation Found in Lymphatic Disorder

Pediatric researchers have identified a gene mutation that causes a serious lymphatic condition, and used that knowledge to restore normal lymphatic vessels in model animals. The laboratory findings may lead to a new therapy for patients with this...
28-Aug-2018 10:00 AM EDT Add to Favorites

Pioneers at Children's Hospital of Philadelphia Greet European Commission's Approval of Kymriah as Landmark Medical Advance for Young Cancer Patients in Europe

Oncologists from Children’s Hospital of Philadelphia today celebrated a watershed moment in medicine: approval by the European Commission of Kymriah (tisagenlecleucel, formerly CTL019) --the first-ever FDA-approved personalized CAR T-cell gene...
27-Aug-2018 9:30 AM EDT Add to Favorites

Two Consumer Baby Monitors Show Worrisome Results in Measuring Vital Signs

Researchers who tested two commercially available baby monitors are raising serious concerns about the accuracy of these products, which are marketed to parents, but are not regulated by the U.S. Food & Drug Administration.
16-Aug-2018 10:05 AM EDT Add to Favorites

A New Autoimmune Disease Is Found, Along with a Personalized Treatment for a Child's Rare Illness

Elijah Patino is a happy, healthy seven-year-old now, but it took a while to get there. For much of his life, he had a mysterious disease that made it painful to eat and painful to play. A pediatric immunologist resolved this "diagnostic odyssey" by...
2-Aug-2018 9:00 AM EDT Add to Favorites

CHOP Nurse-Researcher Presents the Spatz 10-Step System as a National Model for Breastfeeding Vulnerable Babies

Mothers of critically ill infants may not receive necessary breastfeeding support, because their babies may be taken directly to a newborn intensive care unit or to surgery. Lactation expert Dr. Diane Spatz, of Children’s Hospital of Philadelphia,...
31-Jul-2018 12:15 PM EDT Add to Favorites

Six Proposals Receive Seed Funds to Develop Medical Devices for Children

The Philadelphia Pediatric Medical Device Consortium (PPDC) has announced its latest round of seed grants to companies developing medical devices for children. The Consortium, based at Children's Hospital of Philadelphia, chose six companies from...
31-Jul-2018 8:00 AM EDT Add to Favorites

Enzyme Identified as Possible Novel Drug Target for Sickle Cell Disease, Thalassemia

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease. Tests in human cells reveal that blocking the...
16-Jul-2018 3:00 PM EDT Add to Favorites

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