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A Trojan Horse Delivery of Possible Treatment for a Rare, Potentially Deadly, Blood-Clotting Disorder

In proof-of-concept experiments, researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. Researchers deliver a therapeutic enzyme via the cellular equivalent of a Trojan Horse, using platelets...
21-Sep-2018 3:30 PM EDT Add to Favorites


In cardiac injury, the NSAID carprofen causes dysfunction of the immune system

Attention has focused on how NSAIDs may cause dysfunction of the immune system. Researchers now have found that sub-acute pretreatment with the NSAID carprofen before experimental heart attack in mice impaired resolution of acute inflammation...
20-Sep-2018 12:05 PM EDT Add to Favorites

Ketogenic Diet Reduces Body Fat in Women with Ovarian or Endometrial Cancer

Women with ovarian or endometrial cancer who followed the ketogenic diet for 12 weeks lost more body fat and had lower insulin levels compared to those who followed the low-fat diet. Researchers say ketogenic diets limit the ability of cancer to...
18-Sep-2018 5:05 PM EDT Add to Favorites


Enlarged Genotype-Phenotype Correlation for a Three-Base Pair Deletion in Neurofibromatosis Type 1

For people with the genetic disorder neurofibromatosis type 1, a three-base pair deletion in the NF1 gene has a mild phenotype, but the mutation causes complications that include non-optic brain tumors, mostly low-grade and asymptomatic, as well as...
17-Sep-2018 5:05 PM EDT Add to Favorites


Researchers Testing Innovative Childhood Obesity Intervention

UAB researchers will implement a new home-intervention model to teach mothers and children to form healthy habits right in the comfort of their homes.
17-Sep-2018 11:05 AM EDT Add to Favorites


Immune Response Mechanism Described for Fate Determination of T Cells

In a paper published in the journal Science, researchers have detailed a mechanism that sets the stage for the fate decision that gives rise to two major subsets of effector cells: T follicular helper cells and non-T follicular helper cells, known...
13-Sep-2018 3:05 PM EDT Add to Favorites


A “reset” of regulatory T-cells reverses chronic heart failure in mouse model

In mouse experiments, scientists have shown a way to hit an immunological “reset button” that ends inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a...
10-Sep-2018 10:05 AM EDT Add to Favorites


Novel Epigenetic Control Mechanism Found for Critical Brain Proteins in Memory Strengthening

Researchers have found a mechanism that links epigenetic changes to translational control during fear memory reconsolidation — several particular epigenetic changes in the hippocampus of the rat brain control downstream regulation of translation...
6-Sep-2018 4:30 PM EDT Add to Favorites

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Known for its innovative and interdisciplinary approach to education at both the graduate and undergraduate levels, the University of Alabama at Birmingham is an internationally renowned research university and academic medical center, as well as Alabama’s largest employer, with some 23,000 employees, and has an annual economic impact exceeding $7 billion on the state. The pillars of UAB’s mission include education, research, innovation and economic development, community engagement and patient care. Learn more at


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