* * Media Invitation * *

Attacking Insulin Resistance in Type 2 Diabetes: A Novel Approach That Is Changing the Outlook for Patients

The American Association of Diabetes Educators (AADE) and the Endocrine Society invite you to join leading experts in a discussion about a new approach in Type 2 Diabetes management. Learn how patients can better control their disease and avoid the life-threatening complications such as blindness, stroke, kidney failure and heart attack.

Diabetes remains a devastating chronic illness that costs the United States $98 billion each year, more than AIDS and breast cancer combined. Approximately 16 million Americans have diabetes, and Type 2 Diabetes accounts for nearly 95 percent of all diagnosed cases. It is now clear that Diabetes complications are caused by elevated blood sugar levels and may be prevented or reduced by improved control of blood sugar. Researchers have identified a novel approach, which involves targeting insulin resistance - now known to be a key underlying cause of the disease. Although health professionals have suspected insulin resistance for years, only recently has research begun to define how it contributes to Diabetes and its associated complications. Targeting this underlying defect and empowering patients to make lifestyle changes may reduce the risk of many of the life-threatening, life-changing complications associated with Diabetes, including cardiovascular disease, the most common cause of death in people with diabetes.

Please join us to hear about this progressive new paradigm in a brief teleconference/Q & A session.

WHEN: Tuesday, December 8, 1998

10:00 a.m. - 10:45 a.m. (Eastern Standard Time)

WHERE: From your desk via teleconference (specific instructions provided upon confirmation)

WHO: Kathy Mulcahy, R.N., M.S.N., C.D.E. President, American Association of Diabetes Educators

Jerry P. Palmer, M.D., Endocrine Society Member Chief, Division of Endocrinology, Metabolism and Nutrition Department of Veterans' Affairs Puget Sound Health Care System

Director, Diabetes and Endocrinology Research Center and Diabetes Care Center University of Washington

Michael A. Pfeifer, M.D., Endocrine Society Member Director, Obesity and Diabetes Center East Carolina University School of Medicine

Co-Editor, "The Uncomplicated Guide to Diabetes Complications"

HOW: To register, fax back the attached registration form. Participants will

receive a confirmation letter and background information on Diabetes.

CONTACT: Carrie Grzych, (312) 494-4268

FAX BACK REGISTRATION FORM

Attacking Insulin Resistance in Type 2 Diabetes: A Novel Approach That Is Changing the Outlook For Patients

An Educational Telephone Conference and Q&A Session For Medical/Health Reporters

___ YES, I will be participating in the teleconference on Type 2 Diabetes. Please forward a confirmation letter and background information.

___ NO, I will not participate, but please forward background information.

(Please print clearly or type)

Name: __________________________________________
Media: __________________________________________
Address: __________________________________________
City: __________________________________________
State: _____________
Zip: ___________________
Phone: __________________________________________
Fax: __________________________________________

Please extend an invitation to:

Name: ___________________________________________
Media: ___________________________________________
Address: ___________________________________________

City: ___________________________________________ State: _____________ Zip: ___________________ Phone: ___________________________________________ Fax: ___________________________________________

FAX TO: Carrie Grzych, (312) 329-7656

This educational teleconference is being conducted through support from SmithKline Beecham

* * Media Invitation * *

Attacking Insulin Resistance in Type 2 Diabetes: A Novel
Approach That Is Changing the Outlook for Patients

The American Association of Diabetes Educators (AADE)
and the Endocrine Society invite you to join leading
experts in a discussion about a new approach in Type 2
Diabetes management. Learn how patients can better
control their disease and avoid the life-threatening
complications such as blindness, stroke, kidney failure
and heart attack.

Diabetes remains a devastating chronic illness that
costs the United States $98 billion each year, more than
AIDS and breast cancer combined. Approximately 16
million Americans have diabetes, and Type 2 Diabetes
accounts for nearly 95 percent of all diagnosed cases.
It is now clear that Diabetes complications are caused
by elevated blood sugar levels and may be prevented or
reduced by improved control of blood sugar. Researchers
have identified a novel approach, which involves
targeting insulin resistance - now known to be a key
underlying cause of the disease. Although health
professionals have suspected insulin resistance for
years, only recently has research begun to define how it
contributes to Diabetes and its associated
complications. Targeting this underlying defect and
empowering patients to make lifestyle changes may reduce
the risk of many of the life-threatening, life-changing
complications associated with Diabetes, including
cardiovascular disease, the most common cause of death
in people with diabetes.

Please join us to hear about this progressive new
paradigm in a brief teleconference/Q & A session.

WHEN: Tuesday, December 8, 1998

10:00 a.m. - 10:45 a.m. (Eastern Standard Time)

WHERE: From your desk via teleconference (specific
instructions provided upon confirmation)

WHO: Kathy Mulcahy, R.N., M.S.N., C.D.E.
President, American Association of Diabetes Educators

Jerry P. Palmer, M.D., Endocrine Society Member Chief,
Division of Endocrinology, Metabolism and Nutrition
Department of Veterans' Affairs Puget Sound Health Care
System

Director, Diabetes and Endocrinology Research Center and
Diabetes Care Center University of Washington

Michael A. Pfeifer, M.D., Endocrine Society Member
Director, Obesity and Diabetes Center East Carolina
University School of Medicine

Co-Editor, "The Uncomplicated Guide to Diabetes
Complications"

HOW: To register, fax back the attached registration
form. Participants will

receive a confirmation letter and background information
on Diabetes.

CONTACT: Carrie Grzych, (312) 494-4268

FAX BACK REGISTRATION FORM

Attacking Insulin Resistance in Type 2 Diabetes: A Novel
Approach That Is Changing the Outlook For Patients

An Educational Telephone Conference and Q&A Session For
Medical/Health Reporters

___ YES, I will be participating in the
teleconference on Type 2 Diabetes. Please forward a
confirmation letter and background information.

___ NO, I will not participate, but please forward
background information.

(Please print clearly or type)

Name: __________________________________________
Media: __________________________________________
Address: __________________________________________
City: __________________________________________
State: _____________
Zip: ___________________
Phone: __________________________________________
Fax: __________________________________________

Please extend an invitation to:

Name: ___________________________________________
Media: ___________________________________________
Address: ___________________________________________
City: ___________________________________________
State: _____________
Zip: ___________________
Phone: ___________________________________________
Fax: ___________________________________________

FAX TO: Carrie Grzych, (312) 329-7656

This educational teleconference is being conducted
through support from SmithKline Beecham