Mutation in a novel gene is responsible for mild cognitive deficits
The first gene for mild mental retardation (IQs between 50 and 70) called cereblon was identified in a population sample of 29,000 people in the United States. The gene's protein may be involved in regulating the "batteries of the cell" or mitochondria. A growing body of evidence suggests the gene's target, the mitochondria, play a key role in human learning and memory. This discovery may unlock the basic mysteries of human cognition and contribute to a better understanding of mitochondrial function and failure in other neurological disorders such as Parkinson's and Alzheimer's disease.
There will be a press conference about this study held on Monday, November 22, in the Medical Center of New Paltz, New York.
Cholesterol-associated stroke risk varies in subgroups
A case-control study led by David L. Tirschwell, MD, MSc, (University of Washington, Seattle) found that higher total and lower HDL cholesterol levels were associated with increased risk of ischemic stroke, especially for large artery and lacunar subtypes. These associations appear more important in young patients, those with low HDL, non-diabetics, and those without atrial fibrillation. The lowest levels of total cholesterol were associated with an increased risk of hemorrhagic stroke.
The American Academy of Neurology, an association of more than 18,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as epilepsy, dystonia, migraine, Huntington's disease, and dementia.
For more information about the American Academy of Neurology, visit its Website at www.aan.com.
Editor's Note: The AAN office will be closed on November 25 " 26 for Thanksgiving holiday.
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