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American Physiological Society (APS) Releases Highlights from It's Peer Reviewed Journals
EXERCISEEvidence of LPL Gene-Exercise Interaction for Body Fat and LPL Activity: The HERITAGE Family Study
Summary: Evidence of a gene-exercise interaction for traits related to body composition is limited. As part of the HERITAGE Family Study, researchers examined the association between the lipoprotein lipase (LPL) S447X polymorphism, and changes in body mass index, fat mass, percent body fat, abdominal visceral fat (measured by computerized topography), and post-heparin plasma LPL activity.
Methodology: Christophe Garene and his colleagues studied 741 adult white and black subjects and their response to 20 weeks of endurance training. The researchers compared changes between carriers and non-carriers of the X447 allele after adjustment for the effects of age and pre-training values.
Results: No evidence of association was observed in men. However, white women carrying the X447 allele exhibited greater reductions of body mass index, fat mass and percent body fat. In black women, the carriers exhibited a greater reduction of abdominal visceral fat and a greater increase in post-heparin LPL activity.
Conclusions: These results suggest that the LPL S447X polymorphism influences the training-induced changes in body fat and post-heparin LPL activity in women but not in men.
Source: Journal of Applied Physiology, August 2001
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The American Physiological Society (APS) was founded in 1887 to foster basic and applied science, much of it relating to human health.The Bethesda, MD-based Society has more than 10,000 members and publishes 3,800 articles in its 14 peer-reviewed journals every year.
Editor's Note: For the full text of the summaries cited above, or to set up an interview with a lead investigator, please contact Donna Krupa at 703.527.7357 (direct dial), 703.967.2751 (cell) or [email protected].
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