EMBARGOED FOR RELEASE UNTIL 7:30 A.M. MT, APRIL 17, 2002
For more information contact:Kathy Stone, 651-695-2763, [email protected]April 13-20, 303-228-8450
Cheryl Alementi, 651-695-2737, [email protected]
Initial Chemotherapy Treatment Reduces Relapses in MS Patients
DENVER, CO -- Mitoxantrone, a chemical routinely used to fight breast cancer, leukemia and malignant lymphoma, has found a new disease to battle: Multiple Sclerosis. Used in an initial intensive course of chemotherapy (induction therapy), mitoxantrone dramatically decreases disease activity in MS patients for at least four years, according to a study presented at the Annual Meeting of the American Academy of Neurology.
Induction therapy, frequently used against cancers, is designed to wipe out abnormal cells and allow for the regrowth of normal cells. Mitoxantrone for the treatment of MS has recently been approved by the U.S. Food and Drug Administration. It has been used to treat MS in France for more than a decade. Researchers from CHU Pontchaillou of Rennes, France, have demonstrated that mitoxantrone induction therapy for relapsing-remitting MS patients has produced dramatic results in disease activity.
Over the past ten years, 100 worsening relapsing-remitting MS patients were given initial mitoxantrone induction therapy for six months, with mitoxantrone combined with methylprednisolone administered intravenously on a monthly schedule. The annual relapse rate decreased significantly from 3.20 during the 12 months preceding mitoxantrone onset to 0.30 during the first year following induction onset, corresponding to a reduction of nearly 90 percent that was maintained for more than five years. The percentage of relapse-free patients was 76 percent at one year of follow-up, and was maintained at 64 percent, 45 percent, and 43 percent at years two, three and four, respectively, with a median time to the first relapse of 2.8 years.
"The clinical benefit and reduction of disease activity supports our belief that mitoxantrone, as administered in this study, may be an effective induction treatment before initiating other long-term disease modifying therapies for worsening relapsing-remitting MS patients," commented study author Emmanuelle Le Page, MD.
The American Academy of Neurology, an association of 18,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research.
For more information about the American Academy of Neurology, visit its web site at www.aan.com.
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EDITORS NOTE: Dr. Le Page will present the research at the American Academy of Neurology's 54th Annual Meeting in Denver, Colo., during a poster presentation on Wednesday, April 17, 2002 at 7:30 a.m. in Exhibit Hall C of the Colorado Convention Center. He will be available to answer media questions from 3:00 p.m. - 4:00 p.m. on Wednesday, April 17th in the AAN Media Room, Lobby C, Room 208 of the Colorado Convention Center.
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