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Endostatin, a drug that seeks to reduce tumors by cutting off their blood supply, appears to be safe and well-tolerated, according to preliminary results on 19 people studied in Boston.
Evidence for a theory of why incidences of certain cancers grow more common as people age is offered by researchers at Dana-Farber Cancer Institute (Nature, 8-10-00).
Edward J. Benz, Jr., an internationally recognized hematologist, has been named the next president of the Dana-Farber Cancer Institute. Benz is currently chair of the Department of Medicine at Johns Hopkins University School of Medicine.
Researchers at Dana-Farber have developed a new method of isolating specific proteins; the transmembrane proteins "G-protein-coupled receptors" in the Farber study represent one of the most promising targets for new drug therapies.
The trigger for cirrhosis of the liver may be the erosion of tiny, repetitive DNA strands called telomeres that cover the tips of chromosomes and limit the number of times cells may divide, according to Dana-Farber Cancer Institute researchers (Science, 2-18-00).
For pediatric cancer patients, the primary goal of treatment is often to cure; the toxicity of the therapy or the patient's quality of life is often secondary to this goal (New England Journal of Medicine, 2-3-00).
It may be possible to protect infants from acquiring the HIV virus during birth by giving them and their mothers a combination of three potent human antibodies shortly before delivery and after birth (Nature Medicine, 2-00).
The first detailed pictures of key immune system cells locked onto fragments of a foreign substance provide new clues about how the immune system identifies enemy threats and may even lead to a novel way of vaccinating people against diseases to which they are genetically susceptible.
A two-drug therapy that artificially rebuilds the cell's quality-control system can completely destroy human tumor cells grown in laboratory animals, researchers at Dana-Farber Cancer Institute report in the Nov. 9 issue of the Proceedings of the National Academy of Sciences.
Women who begin alternative medical therapies in the wake of a breast cancer diagnosis exhibit greater psychosocial distress, according to a study by researchers at Dana-Farber Cancer Institute and Harvard Medical School published in the June 3rd issue of the New England Journal of Medicine.
In a study with powerful implications for people needing organ and tissue transplants, researchers at Dana-Farber Cancer Institute and Harvard Medical School have devised a new technique that may make transplants available to nearly everyone with a partially matched donor.
In a pair of studies that promise to rewrite scientists' understanding of genetic "tripwires" that kill cells before they become fully cancerous, researchers at Dana-Farber Cancer Institute have found that the same system that protects against cancer can, in some circumstances, actually promote cells on the road toward malignancy.
Scientists at Dana-Farber Cancer Institute and Duke University Medical Center have uncovered a new portion of the circuitry that controls the natural death of cells, they published in the April 23 issue of Science.
In a study that points the way to a new form of cancer therapy, researchers at Dana-Farber Cancer Institute and Harvard Medical School report that a drug commonly used to treat diabetes has caused tumor cells to shift to a slower-growing, less-menacing state in patients with a rare type of cancer.
In a study that confirms warnings issued by researchers four years ago, the same researchers now report that both infant and adult monkeys vaccinated with a live, weakened form of an HIV-like virus have developed AIDS from the vaccine virus itself.
The "International Conference on the Prevention and Early Diagnosis of Lung Cancer" today release an unanimously agreed upon statement calling for the need to address screening and early detection of lung cancer.
In an unexpected spin-off of cancer research that began more than a decade ago, scientists at Dana-Farber Cancer Institute have succeeded in reducing atherosclerosis - hardening of the arteries - by 80 percent in mice by blocking a gene in mice that is virtually identical to one in humans.
In experiments with mice, researchers at Dana-Farber Cancer Institute and Children's Hospital (Boston) have used a naturally occurring protein to thwart one of the most common -- and potentially lethal -- complications associated with bone marrow transplants.
Researchers at Dana-Farber Cancer Institute and Columbia University have obtained the first detailed, three-dimensional picture of the lock-and-key mechanism by which HIV-1 binds to blood cells -- a milestone in the effort to develop AIDS vaccines that are effective against many strains of the virus.
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