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Forty-nine percent of the adult population will have at least one risk factor for cardiovascular disease. Heart disease remains the leading cause of death in the United States The good news? It can be prevented. Judith Mackall, MD, Cardiologist at University Hospitals (UH) Case Medical Center in Cleveland, Ohio, offers three tips for men and women to help improve their heart health and reduce the risk of developing heart disease.

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New twilight sedation for advanced heart valve disease patients undergoing the minimally invasive TAVR, or transcatheter aortic valve replacement, cuts hospital stay, cost, and additional medications.

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Announcement by HIMSS Analytics that University Hospitals in Cleveland has achieved Stage 6 status on the EMR Adoption ModelSM (EMRAM).

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“This study provides several important observations,” said Dr. Raymond Onders, Director of Minimally Invasive Surgery at University Hospitals Case Medical Center. “Most notably, laparoscopic diaphragm mapping – an electronic reading of the diaphragm nerves – is safe and can be performed in multiple centers with success. In addition, early diaphragm mapping can quickly determine if a phrenic nerve injury is complete, allowing for early ventilator planning and prevention of weaning trials if we find the patient will not be able to be weaned from the ventilator. Finally, DP can successfully wean traumatic cervical SCI patients as evidenced by 72 percent of the implanted patients being completely weaned from ventilators and 36 percent with complete recovery and DP removal.

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Researchers from University Hospitals Case Medical Center and Case Western Reserve University School of Medicine have published new findings in the February issue of American Journal of Roentgenology that mammography remains beneficial for women in their 40s. According to the study, women between ages 40 and 49 who underwent routine screening mammography were diagnosed at earlier stages with smaller tumors and were less likely to require chemotherapy.

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Rose Gubitosi-Klug, MD, PhD, writes the summary and future directions in the journal Diabetes Care for a series of papers from Diabetes Control and Complications Trial (DCCT) and follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC). The studies enrolled more than 1,400 adolescents and young adults with type 1 diabetes to evaluate if intensive control of diabetes could lower the risk of complications better than conventional control. EDIC continues to follow many of the original participants.

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Minority of panel members who disagree with raising systolic blood pressure targets for people over 60 years of age provide their evidence in a new commentary in the Annals of Internal Medicine.

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Promising results from a Phase III study published in this week’s New England Journal of Medicine finds upper airway electronic stimulation to be effective in reducing obstructive sleep apnea (OSA) symptoms.

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University Hospitals (UH) Bedford Medical Center, a campus of UH Regional Hospitals, has launched a new program to help older adults live healthier, more independent lives. The new center can serve as a model for working with older patients and their families.

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New research examined how changes in the genetic composition of breast cancer tumors after brief exposure to either biologic therapy or chemotherapy can predict future clinical outcomes in patients.

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University Hospitals Rainbow Babies & Children’s Hospital is one of only 13 children’s hospitals in the country – and the only one in northern Ohio – to receive the Top Children’s Hospital distinction from The Leapfrog Group. UH Rainbow was selected out of a record number of 1,324 hospitals participating in The Leapfrog Group’s annual survey.

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A neuroradiologist inserts a micro-catheter into an aneurysm and injects a fluorescent dye, a complex, rare and new procedure which provides a neurosurgeon a clear view of the blood vessel that feeds the aneurysm. The surgeon then knows where to sew in a transplanted blood vessel to bypass the aneurysm.

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Jonathan Stamler, MD, received the 2013 American Heart Association Distinguished Scientist Award at the association’s annual conference in Dallas. He discovered a process, termed S-nitrosylation, by which nitric oxide attaches to proteins to control cellular function.

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New research study finds that children ages 1 to 3 years account for one-fifth of all emergency department visits caused by complications from asthma, representing the highest proportion of visits among asthma patients under age 21. In addition, 55 percent of all ED visits due to asthma occur in boys, and fall months – September, October and November – have a relatively high proportion of visits compared to other times of the year. The research was presented at the American Academy of Pediatrics (AAP) National Conference in Orlando. At AAP, the same research team also presented an analysis of adverse drug events (ADE) among hospitalized children in the U.S. from 2003 to 2010. Results reveal that medication errors and ADEs in pediatric inpatient settings gradually increased between 2003 and 2010, although the cause for this increase requires further study.

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From Neurodegeneration to Brain Health: An Integrated Approach -- Conference

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CLEVELAND: New recommendations for overcoming issues related to cancer clinical trial accrual have been published online in the Journal of Oncology Practice. Following a National Cancer Institute (NCI) and American Society of Clinical Oncology (ASCO) co-sponsored symposium, the research team compiled a summary of best practices and strategies for future research aimed at advancing cancer trials more rapidly. “Cancer clinical trials provide the evidence base for new advances in oncology. However, only a few percent of cancer patients participate in them,” says Neal J. Meropol, MD, senior author, Chief of the Division of Hematology and Oncology at UH Case Medical Center and Case Western Reserve University School of Medicine. “Poor enrollment onto trials threatens to slow progress in cancer care at a time when advances in science are enabling new opportunities for prevention and treatment."

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Advanced imaging with Positron Emission Tomography (PET) scan shows great promise in predicting which patients with inoperable lung cancer have more aggressive tumors and need additional treatment following standard chemotherapy/radiation therapy, according to new research recently published online in the Journal of Clinical Oncology. The multi-site trial, led by study author and principal investigator Mitch Machtay, MD, University Hospitals Case Medical Center Seidman Cancer Center, enrolled 250 patients at 60 cancer centers around the country.

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By studying the genetic makeup of breast cancer patients, doctors are taking the next steps forward in delivering more personalized care to patients. Whole genome sequencing from cancers is not a new concept, but recently researchers have delved more deeply into the evolution of breast cancers identifying that it comes in four distinct types. Breaking down how the cells of each sub-type of the disease function is allowing for doctors to customize treatments for improved outcomes.