As the opioid tramadol has grown in popularity so too have documented cases of adverse effects. In a new study, researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego show that patients who take tramadol are at greater risk for hypoglycemia, abnormally low blood sugar.
For the first time in Southern California, surgeons at UC San Diego Health have transplanted the kidney of a deceased donor with HIV into a recipient with a pre-existing HIV infection. The procedure is part of an unprecedented multi-site national clinical trial.
In a survey, UC San Diego researchers report most patients are willing to share medical records for research purposes, with a few caveats.
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.
UC San Diego School of Medicine has been awarded $9 million to fund research projects using human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes aimed at identifying the cellular actions leading to disease onset.
UC San Diego researchers discovered that removing a single enzyme in mice dramatically boosts survival from sepsis, an often fatal over-reaction of the immune system to infection. The finding provides a new and unexpected therapeutic target for new drug development.
The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study published in Science Translational Medicine.
In a Phase III clinical trial, the drug volanesorsen significantly reduced blood fat (triglyceride) levels in participants with a rare disease called familial chylomicronemia syndrome; finding could also help inform better prevention methods and treatments for many types of heart disease.
The heart transplant program at UC San Diego Health has demonstrated the best one-year survival rate for patients in the United States among health care providers with a volume of more than 50 heart transplants per year, according to the Scientific Registry of Transplant Recipients.
UC San Diego Health has been recognized among the nation’s best hospitals for 2019-20 by U.S. News & World Report. The annual “Best Hospitals” rankings are designed to assist patients and their doctors in making informed decisions about where to receive care for challenging health conditions.
A genome-wide association study of more than 165,000 U.S. veterans confirms a genetic vulnerability to post-traumatic stress disorder, specifically noting abnormalities in stress hormone response and/or functioning of specific brain regions.
UC San Diego researchers have used the transcriptome — the sum of all messenger RNA (mRNA) molecules expressed from genes — to map protein-gene interactions involved in Alzheimer’s disease.
University of California San Diego School of Medicine scientists say the loss of a single gene two to three million years ago in our ancestors may have resulted in a heightened risk of cardiovascular disease in all humans as a species, while also setting up a further risk for red meat-eating humans.
The T. Denny Sanford Institute for Empathy and Compassion at UC San Diego will investigate the neurological basis of compassion, design a compassion-focused medical curriculum and develop new methods to protect and promote the well-being of current clinicians and their patients.
A dysfunctional enzyme involved in building cancer cell membranes helps fuel tumor growth; when it’s disabled or depleted in mouse models, tumors shrank significantly.
UC San Diego will launch a payload of stem cell-derived human brain organoids to the International Space Station. Researchers will document how these “mini brains” organize into the beginnings of a functional brain with implications for the future of human life in space.
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