Researchers have identified a new protein required for the circadian response to light in fruit flies. Understanding how light affects 24-hour rhythms will likely open doors to future treatments of jetlag.
For nearly a half a century, Wallace Miller, Sr., MD has been scrutinizing images in the dark at the Hospital of the University of Pennsylvania (HUP) - and for the last 20 years, his son, Wallace Miller, Jr., MD, has been right by his side. Together, as chest radiologists in the Thoracic Imaging Division at Penn, this father-son duo has read close to one and a half million chest X-ray exams over the years!
Researchers have identified a striking dysregulation in neuronal receptor activity in the postmortem brain tissue from patients with schizophrenia. Identifying a relationship between the two receptor groups suggests a mechanism for decreased function that has long been suspected in schizophrenia.
Researchers have discovered that a brain region previously known for its role in learning and memory also serves as the location of sleep regulation in fruit flies.
Cold sores, caused by a herpes virus, come back again and again. Researchers found that a microRNA keeps the latent virus-infected cell alive, offering the first target for intervention in the latent infection.
A transcription factor called Elk-1 interacts with mitochondria, suggesting that this protein "“ typically active in the nucleus "“ could play a role in cell death, and mitochondria-related diseases such as neurodegeneration and schizophrenia.
COX enzymes interact physically to form a previously unrecognized biochemical partnership and function in the development of blood vessels in a mouse model, which suggests new biological, developmental, and therapeutic roles.
Researchers in the largest study to date of female heart failure patients who underwent a specialized stress test called oxygen uptake or VO2 -- concluded that women tend to have lower maximum exercise VO2 levels than men, yet their survival is significantly better than men. The results suggest that instead of one standard cut-off level in VO2 test results for both men and women, perhaps there should be a lower cut-off level for women.
The Hospital of the University of Pennsylvania (HUP) is now home to three brand new, state-of-the-art, high powered MRI (Magnetic Resonance Imaging) systems. The combination of the three units is a "Radiology First" for any hospital in the United States, which is especially fitting since HUP was the first hospital to get and use an MRI back in 1984.
Researchers at the University of Pennsylvania School of Medicine are working on ways to improve the results of a non-surgical method to treat fibroids. They are examining the overall effectiveness of different agents used to destroy uterine fibroids - a discovery that could lead to more answers about the durability of a procedure called Uterine Fibroid Embolization (UFE).
A new study indicates that the use of a simple and inexpensive computer-based questionnaire increases the odds, but did not guarantee that domestic violence would be addressed during emergency department encounters.
The new center will study the effects of environmental pollutants on human health. Researchers will study the role of environmental exposure in lung disease, including cancer, mesothelioma, asthma, and emphysema, as well as diseases of the hormonal and reproductive systems, which include pre-term birth and birth defects.
Marisa Bartolomei, PhD, Associate Professor of Cell and Developmental Biology was awarded the first annual Society for Women's Health Research Medtronic Prize for Scientific Contributions to Women's Health. She was recognized for her work in the field of sex differences research and women's health.
Epidemiologist Brian L. Strom, MD, MPH, analyzes the limitations of the current system of drug-safety monitoring and proposes an alternative approach with three elements.
A new "Center for Spirituality and the Mind" has been created at the University of Pennsylvania School of Medicine to support campus-wide researchers from a wide variety of academic disciplines who will further our understanding of what it means to be "religious" and "spiritual." The multi-disciplinary teams of researchers will study the issue from a number of related perspectives.
Researchers have located the cause of fibrodysplasia ossificans progressiva (FOP) - a gene that, when damaged, causes the body's skeletal muscles and soft connective tissue to undergo a metamorphosis into a "second skeleton."
Researchers have clarified the mechanism by which drugs like Celebrex and Vioxx cause heart problems, in multiple animal models. The findings suggest a new generation of anti-inflammatory drugs that bypass this issue.
Virginia A. LiVolsi, MD, Professor of Pathology at the U of Pennsylvania School of Medicine, will be a key presenter at the "Living with Radiation in the Modern World: Commemorating Chernobyl, Remembering Hiroshima / Nagasaki," conference to commemorate the 20th anniversary of the Chernobyl nuclear reactor meltdown.
The Hospital of the University of Pennsylvania (HUP) is proud to announce that its Rhoads 5 Surgical Critical Care Team has earned the Beacon Award for Critical Care Excellence, an award given by the American Association of Critical-Care Nurses (AACN) and specifically designed to recognize the nation's top hospital critical-care units.
Daniel Rader, MD, a specialist in preventive cardiovascular medicine at the U of Pennsylvania School of Medicine has been selected to direct a prestigious Freedom to Discover Unrestricted Biomedical Research Grant awarded to the U of Pennsylvania School of Medicine by Bristol-Myers Squibb.
Transfusion-free cardiac surgery is now available at the University of Pennsylvania Health System to anyone who wants it and qualifies as a good candidate. Patients receive no foreign blood, reducing the risk of complications and a long hospital stay.
An HIV-1 accessory protein called Vpr destroys the host cell's ability to survive by binding to a host receptor, disabling the host immune system via another enzyme. These findings imply new approaches to treating AIDS, inflammatory diseases, and possibly sepsis.
Researchers have discovered how a protein called Pmel17 is sorted by pigment cells in the skin and eye to make a fiber matrix that eventually sequesters melanin, the dark pigment found in skin, hair, and eyes.
Ilene Rosen and Richard Schwab spend their days examining and explaining to patients what may be causing their lack of sleep. As we approach National Sleep Awareness Week, set to begin on March 27th, these sleep physicians are offering up some "Wow, I didn't know that!" factoids when it comes our very treasured zzzzz's.
Jon Epstein, MD, Professor of Medicine and cardiovascular researcher at the University of Pennsylvania School of Medicine, has been selected as this year's winner of the American Federation for Medical Research's Outstanding Investigator Award, the organization's top honor for medical investigation.
Researchers have developed a new, simple technology that can detect even a few molecules of proteins in the blood. It will make discerning low-abundance molecules associated with cancers, Alzheimer's disease, and prion diseases more sensitive and more accurate compared with current methods.
Researchers discovered the mechanism that facilitates how two ion channels collaborate in the control of electrical signals in the brain. They showed that the channels were anchored by a third protein at key locations on the nerve cell surface, and also found that the channel partnership is present in all vertebrates, but lacking in invertebrates.
Can someone who suffers from a lethal genetic disease teach a pair of medical students to become better doctors? That's the goal of a unique, long-term patient-student pairing program at the U. Penn School of Medicine. This unique, long-term three year program helps to humanize patients in the eyes of future doctors.
Researchers at the University of Pennsylvania School of Medicine have found that leaving a mildly underactive thyroid gland (subclinical hypothyroidism) untreated does not lead to increased cardiovascular risk.
Researchers from the University of Pennsylvania School of Medicine received $1.1 million dollars from the Cardiovascular Medical Research Education Fund to establish the Penn Idiopathic Pulmonary Arterial Hypertension Center for Cell Studies.
Researchers at the University of Pennsylvania School of Medicine say preliminary results of a small study show promise in improving erectile dysfunction (ED) in men who had shown minimal reaction to Viagra.
The Hospital of the University of Pennsylvania is ready for a very traumatic visit. In conjunction with Sweden's Linkoping University's Center for Disaster Medicine and Traumatology, HUP will be hosting four sets of four general surgeons.
Researchers discovered that a key receptor protein is a critical component of the internal molecular clock in mammals. What's more, this molecule - called Rev-erb - is sensitive to lithium and may help shed light on circadian rhythm disorders, including bipolar disorder.
Researchers have identified a second molecular pathway that promotes cell survival in low-oxygen conditions. With the details of cellular adaptation during hypoxia, they hope to gain a better understanding of the abnormal environments that are characteristic of many diseases, including solid-tumor cancers and stroke.
Neurosurgeons are now using virtual reality, 3D imaging for surgical planning, evaluation, and education. Prior to walking into the Operating Room, neurosurgeons can now use a Dextroscope® to create interactive, 3D images of their patient's brain to plan the best surgical approach for a diagnosed condition.
Researchers have created "“ in a rodent model "“ a completely new way to engineer nerve structures, or constructs, in culture. This proof-of-principle research has implications for eventually becoming a new method to repair spinal cord injury in humans.
In a mouse model, researchers discovered that olfactory sensory neurons expressing the same receptor responded to a specific odor with an array of speeds and sensitivities, a phenomenon previously not detected in the mammalian sense of smell. Findings may help revise models of olfaction.
Injured spinal neurons establish specialized bridges to connect with other injured neurons, according to new findings. Interestingly, the injured cells reach out only to each other in this process, excluding healthy neighboring cells from the network. The bridges, common during development, are rarely seen in the adult nervous system.
Electron transfers represent the fundamental atomic-level exchanges underpinning the energy economies of all living things, and the results have important implications in terms of evolution and drug development.
The cells powering the heartbeat actively protect themselves from oxygen levels that are either too high or too low, a new study finds. That heart cells avoid low oxygen levels is not surprising, but this study is the first to show that they also will not tolerate high oxygen levels.
Light drinking of alcohol appears to have modestly beneficial effects on the cardiovascular system, according to some studies. A new study, however, shows that heavier consumption of alcohol initiates a free-radical mediated process that has been linked to heart disease, stroke, cirrhosis of the liver, and many other disorders.
Researchers at the University of Pennsylvania Medical Center have solved the molecular intricacies of how a fruit fly controls the synchronization of its internal clock to cycles of light and dark.
Women carrying a mutation in the BRCA1 gene can cut their breast cancer by 70 percent by undergoing a bilateral prophylactic oophrectomy, or removal of their two ovaries, researchers at the University of Pennsylvania Cancer Center published in the September 1, 1999 issue of the Journal of the National Cancer Institute.
For the first time in an animal model, researchers at Penn have shown that Alzheimer's-like pathology is triggered in the brain following head trauma. This provides experimental evidence that brain trauma is a risk-factor for Alzheimer's.
Bioengineers from the University of Pennsylvania have increased the expression of marker DNA by 60 times over previous attempts with nonviral vectors. A genetic tag of a nuclear protein provided the molecular key to the nucleus.
Researchers at the University of Pennsylvania Medical Center have shown that a class of anti-diabetic agents currently on the market dramatically decreases the symptoms of inflammatory bowel disease in mice.
A common antibiotic called gentamicin might be able to completely arrest disease progression in about 15 percent of Duchenne muscular dystrophy patients, according to a new study in mice. Additionally, the approach might prove effective for a similar subset of people suffering from other genetic disorders.
A University of Pennsylvania Medical Center team found that tumor necrosis factor (TNF) -- a cytokine molecule that is normally released during inflammation -- may be damaging and then protective to brain-injured tissue, depending on the time course after injury.
Researchers at the University of Pennsylvania Medical Center have devised a safer, more effective strategy for bone marrow transplantation that does not require the use of drugs that globally suppress the immune system. A report on the new technique, demonstrated in mice, appears in the July 16 issue of Science.
Physicists from the University of Pennsylvania have found a new class of materials that self-assemble into flat, two-dimensional "crystallites" made from tiny plastic beads the size of bacteria. The beads seem to defy the basic physical principle that oppositely charged objects attract.
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