Researchers at McMaster University have developed a new form of rapid test to detect infections in farm animals, responding to the rising threat of dangerous outbreaks.
McMaster University scientists who compared respiratory vaccine-delivery systems have confirmed that inhaled aerosol vaccines provide far better protection and stronger immunity than nasal sprays.
Older adults with Type 1 diabetes (T1D) are at significantly higher risk of both muscle weakening and cardiovascular complications, say McMaster University researchers
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McMaster University researchers behind a new form of rapid, accurate and portable diagnostic test are moving their work toward the marketplace.
McMaster researchers tracked 501 patients with luminal A breast cancer for five years post-surgery and found the recurrence of cancer in the breast was just 2.3 per cent without radiotherapy. This was roughly comparable with a 1.9 per cent risk this patient sample had of developing a new breast cancer in their other untreated breast.
At the beginning of the COVID-19 pandemic, prone positioning was believed to be a potentially useful intervention – one that warranted further investigation. While some studies suggested awake prone positioning was safe, there was insufficient evidence to recommend using this strategy in clinical guidelines. COVI-PRONE, designed to provide robust evidence, included 21 hospitals in Canada, Saudi Arabia, Kuwait, and the United States. Researchers aimed to use prone positioning in hypoxemic COVID-19 patients for 8 to 10 hours per day, with 2 to 3 breaks, as needed. Participants in the control group were not proned and were asked not to position themselves in the prone position.
McMaster University researchers have discovered that Type I interferon (IFN) plays a key role in helping the immune system effectively target viruses, while stopping white blood cells from ‘going rogue’ and attacking the body’s own organs.
McMaster University researchers who study the dynamics of infectious disease transmission have investigated the population-level consequences of a potentially significant––and unobvious––benefit of wearing masks.
A study has demonstrated that a new type of cardiac defibrillator called a subcutaneous ICD (S-ICD) reduced patient complications by more than 90 percent, compared to the TV-ICD. The study involved 544 eligible patients (one-quarter females) with average age of 49, at 14 clinical centres in Canada
The researchers of McMaster’s Centre for Metabolism, Obesity and Diabetes Research performed MRI scans to measure BAT activity in 26 boys between the ages of eight and 10. They studied the BAT tissue in the neck before and after one hour of exposure to a cold suit set at a temperature of 18 degrees Celsius. The patient sample included 13 boys with a normal BMI and the same number again with obesity, in the first study of its kind in children.
Cycling for 35 minutes three times a week for 12 weeks led to a 32 per cent increase in overall fitness in people with MD. Patients who took part in the study also saw a 1.6-kilogram increase in their muscle mass and a two per cent reduction of body fat. They were also able to walk an extra 47 metres in six minutes, when tested by researchers at the end of the 12-week trial. Eleven patients took part in the study.
The drug tested, tranexamic acid (TXA), was given to patients at risk of bleeding or vascular complications. The study found that TXA did not increase deep vein clotting known as VTE, heart attack, non-hemorrhagic stroke, or other major vascular complication in the 30 days after surgery. In the study, half of 9,535 patients in 22 countries were randomly assigned TXA, half placebo. Patients were 45 years or older (average age 69 years); 44% of them were female.
McMaster researchers have been able to re-engineer red blood cells and use them as a promising new vehicle for vaccine delivery.
This study, published in the New England Journal of Medicine, assessed patients having heart surgery, measured troponin before and daily for the first few days after surgery, and assessed death and the incidence of major vascular complications – such as heart attack, stroke or life-threatening blood clot – after heart surgery. The study involved 15,984 adult patients with an average age just over 63 years undergoing cardiac surgery. Patients were from 12 countries, with more than a third of the countries being outside of North America and Europe.
New research by the inventors of a promising pathogen-repellent wrap has confirmed that it sheds not only bacteria, as previously proven, but also viruses, boosting its potential usefulness for interrupting the transmission of infections.
Scientists have a new understanding of the protective effects of caffeine on the cardiovascular system. While its stimulant effects have long been characterized, a team of McMaster University researchers have discovered how caffeine interacts with key cellular factors to remove cholesterol from the bloodstream.
Scientists at McMaster University who have developed an inhaled form of COVID vaccine have confirmed it can provide broad, long-lasting protection against the original strain of SARS-CoV-2 and variants of concern. The research, recently published in the journal Cell, reveals the immune mechanisms and significant benefits of vaccines being delivered directly into the respiratory tract, rather than by traditional injection.
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Researchers at McMaster University have found that children who receive years of season-specific flu vaccines develop antibodies that also provide broader protection against new strains, including those capable of causing pandemics.
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