In experiments in the lab and with guinea pigs, researchers have found the first evidence that genetically engineered heart cells derived from human embryonic stem cells might one day be a promising biological alternative to the electronic pacemakers used by hundreds of thousands of people worldwide.
In animal studies, researchers at Johns Hopkins have effectively used magnetic resonance imaging to measure with 94 percent accuracy the size and amount of heart muscle damaged by a heart attack, known in medical terms as a myocardial infarct, or m.i., for short.
For 50 years, thousands of labs around the world have studied cells' critical internal communications, and scientists had assumed the speakers were known. But now researchers report finding not just a new participant, but a brand new conversation that has implications for treating disease and understanding biology.
In experiments with fruit flies, researchers have found that blindness induced by constant light results directly from the loss of a key light-detecting protein, rather than from the overall death of cells in the retina, which in humans is a light-sensitive tissue at the back of the eye.
Johns Hopkins scientists have discovered how one family of proteins repels growing nerves and keeps them properly on track during development. The finding might provide a chance to overcome the proteins' later role in preventing regrowth of injured nerves, the researchers say.
Johns Hopkins Kimmel Cancer Center scientists say chronic stress may speed development of skin cancer in those at high risk for the disease. They found that mice exposed to stressful conditions and UV light develop skin cancers in less than half the time as unstressed mice.
A multicenter study of 821 patients referred for breast biopsy based on prior examinations that suggested cancer finds that while magnetic resonance imaging distinguishes between benign and malignant breast tumors better than mammography, biopsies are still needed to confirm the diagnosis.
As many as 28,000 patients die each year in the U.S. because of catheter-related bloodstream infections, but doctors and nurses who implement simple and inexpensive interventions can cut the number of deaths to nearly zero, according to a study by Johns Hopkins researchers.
Johns Hopkins researchers say there is growing evidence that stem cells gone awry in their efforts to repair tissue damage could help explain why long-term irritation, such as from alcohol or heartburn, can create a breeding ground for certain cancers.
"Sit-down" medical rounds, during which a health care team meets to review a patient's medical record and discuss short- and long-term needs, are associated with better outcomes for kidney dialysis patients, a Johns Hopkins-directed study has found.
In experiments with mice, a team has discovered an unusual protein pair that stops blood vessels' growth in the developing back. Results are of special interest to researchers trying to prevent blood flow that nourishes tumors or exploit the signals vessels emit during growth to help regrow damaged nerves.
Scientists have created a new tool that easily reveals when and where a key cellular signal is active. The development should speed identification of the signal's triggers and effects in normal processes and in conditions such as asthma, allergy, inflammation, lung disease and heart disease.
A Johns Hopkins study has found new evidence that the brains of some people with autism show clear signs of inflammation, suggesting that the disease may be associated with activation of the brain's immune system.
Scientists at Johns Hopkins have linked a stem-cell gene to a portion of one of the most common childhood brain cancers, opening the door to tailored therapies that block the gene's tumor-promoting ability.
1) "Painting" technique successfully transfers gene therapy to heart; 2) Traditional risk factors fail to identify women at high risk of heart disease; 3) Ultrasound of carotid artery in neck detects early signs of heart failure; 4) "Wallflower" biochemical pathway has protective role in heart failure.
Researchers at Johns Hopkins report that use of high-dose vitamin E supplements, in excess of 400 IU, is associated with a higher overall risk of dying. These results should be of concern to the millions of Americans who take vitamin E supplements for perceived health benefits.
Results from an animal study conducted at Johns Hopkins show that stem cell therapy can be used effectively to treat heart attacks, or myocardial infarcts, in pigs. Stem cells taken from another pig's bone marrow, when injected into the animal's damaged heart, were able to restore the heart's function to its original condition.
Children who outgrow peanut allergy have a slight chance of recurrence, but researchers from the Johns Hopkins Children's Center report that the risk is much lower in children who frequently eat peanuts or peanut products.
In human and animal studies, scientists at Johns Hopkins have developed a fast and safe method for collecting heart stem cells from remarkably small amounts of biopsied heart tissue (15 mg or less), and growing the cells in the lab to get more.
Researchers at Johns Hopkins have shown that genetic testing can be effectively used to distinguish between heart failure patients who suffer from ischemic or nonischemic forms of the disease.
Johns Hopkins researchers have built a powerful "toolkit" designed to quickly uncover how yeast's genes interact with each other.
1) Ways to watch your waistline at the holidays; 2) Holiday food tips for people with diabetes; 3) When a diet is more than a diet: eating disorders and young adults.
The politically savvy may be aware that just eight of the current 535 members and four delegates of the 108th Congress are physicians.
Listed below are several key presentations surrounding the 44th ICAAC from researchers affiliated with Johns Hopkins.
Adults who dispense eye drops daily to correct a child's "lazy eye" take note: a new study finds that giving the drops just twice during the weekend is just as effective as administering them every day of the week.
Scientists have designed a new molecular tool, dubbed "LigAmp," to pinpoint DNA mutations among thousands of cells, the equivalent of searching for a single typo in an entire library of books.
In studies with mice that develop the equivalent of Alzheimer's disease that runs in families, Johns Hopkins researchers have shown that brain cells' signals confuse the movement of implanted neuronal stem cells.
Researchers at Johns Hopkins have dispelled the widespread belief among obstetricians that, in premature infants, brain injury results from a lack of oxygen, also called hypoxia, when, in fact, infection plays a larger role.
Johns Hopkins researchers have found that transplants of mouse stem cells taken from the adult brain's olfactory bulb can delay symptoms and death in a mouse model of amyotrophic lateral sclerosis, or Lou Gehrig's disease.
Human primitive spinal cord cells delayed symptoms and paralysis by a week when implanted in the spinal cord of rats destined to develop amyotrophic lateral sclerosis, or Lou Gehrig's disease, researchers from Johns Hopkins report.
After five years of work, Johns Hopkins researchers report that a particular genetic region long assumed to be a critical factor in Down syndrome isn't nearly as important as once thought.
The Johns Hopkins University School of Medicine has established a clinic focused on the treatment of body fat and metabolic changes that profoundly affect people undergoing therapy for HIV and AIDS.
Researchers from the Johns Hopkins Children's Center say a group of drugs known as "atypical antipsychotics" that are commonly used to treat children with aggression, bipolar disorder, and schizophrenia may trigger insulin resistance.
Johns Hopkins' Genetics and Public Policy Center, with funding from The Pew Charitable Trust, convened an expert panel to address whether IVF babies are at increased risk for adverse health outcomes.
Agents believed to selectively "restart" genes that limit cancer's growth -- a potential treatment option already in early clinical studies -- instead turn off as many genes as they turn on, a team of researchers from the National Cancer Institute and Johns Hopkins has discovered.
Researchers have discovered that an apparently nontoxic cellular "energy blocker" can eradicate large liver tumors grown in rats. Six months to more than a year after treatment was stopped, the rats are still cancer free.
With a three-year, $3.2 million grant from the National Institute of Mental Health, Johns Hopkins scientists will lead the largest hunt for genetic contributors to autism, a neuropsychiatric condition whose causes are almost as mysterious today as when the condition was first described in 1943.
Using modified magnetic resonance imaging (MRI) techniques, researchers at Johns Hopkins have been able to detect the early benefits of a cholesterol-lowering medication much sooner than before.
The Johns Hopkins Kimmel Cancer Center has won a five-year, $10 million government grant that will bring together national breast cancer experts to find new ways to halt metastasis, an elusive process that causes cancer cells to spread throughout the body and is the cause of death in most cancer patients.
In a three-year analysis of more than 10,500 genes, one-third of the human genome, researchers at Johns Hopkins have found a starting point to establishing the genetic basis for sinus disease and the growth of nasal polyps, illnesses not well understood despite their prevalence.
A new study shows that lower doses of radiation elude a damage detection "radar" in DNA and actually kill more cancer cells than high-dose radiation. With these findings, scientists believe they can design therapy to dismantle this "radar" sensor allowing more radiation to evade detection and destroy even greater numbers of cancer cells.
A new study from Johns Hopkins suggests that routine widening of the vagina, a procedure known as an episiotomy, does not reduce the risk of injury to infants during a complicated birth, such as when a baby's shoulders are stuck in the birth canal after the head is already out.
Researchers at Johns Hopkins have found that sibling history - whether or not a brother or sister had early heart disease - is a better predictor of a person's likelihood of developing coronary heart disease than parental history or traditional risk factor scoring.
If you missed your morning coffee and now you have a headache and difficulty concentrating, you might be able to blame it on caffeine withdrawal. In general, the more caffeine consumed, the more severe withdrawal symptoms are likely to be, but as little as one standard cup of coffee a day can produce caffeine addiction.
A new, government-funded study at Johns Hopkins will provide much-needed information about conflict of interest in medical research. The $3 million, four-year investigation will explore the difficult issue of how best to disclose such conflicts to potential participants in research.
The Congressional Black Caucus and The Johns Hopkins University will host a meeting of African American leaders to examine issues in race and genetics on October 4.
A Johns Hopkins study suggests that people with type I and type II diabetes would be well advised to monitor their blood sugar levels more than the usual twice daily to make sure that levels are not elevated over 150 milligrams per deciliter for sustained periods.
Cancer researchers have long suggested that new targeted drugs may work best when paired with other therapies. In a new study, scientists have taken some of the first steps to demonstrate this synergy in mouse and cell line models.
Johns Hopkins researchers have discovered a possible way to distinguish lethal metastatic prostate cancers from those restricted to the walnut-size organ.
Researchers have discovered that many people with Bardet-Biedl syndrome, a rare, complex condition marked by an array of seemingly unconnected symptoms, including obesity, learning difficulties, eye problems and asthma, also have another, previously unreported problem: many of them can't detect odors.
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