A new study from the Johns Hopkins Children's Center and 12 other medical centers shows the most effective treatment for adolescents with major depressive disorder is a combination of antidepressants and psychotherapy.
Comparative genomics and some good old-fashioned genetic analysis have allowed scientists to uncover the identity of the last of eight genes known to be involved in Bardet-Biedl syndrome, a rare disorder characterized by obesity, learning difficulties, diabetes and asthma.
Researchers have designed a blood test to detect ovarian cancer using three proteins found in common in the blood of women with the disease. Their preliminary studies suggest a molecular signature exclusive to this deadly cancer, known for its ability to remain undetected and spread quickly.
Although the majority of children outgrow allergies to bee, wasp and other insect stings, almost one in five who had allergic reactions when stung as children - especially those who had serious allergic reactions -- are likely to have reactions later in life.
Researchers have found that genes involved in suppressing the body's defensive "killer" immune cells are a potential key factor in spontaneous recovery from hepatitis C. The viral infection of the liver can lead to cirrhosis, cancer and even death.
In animal and laboratory studies, scientists have shown that modern, implanted heart assist devices can be safe for use in MRI machines, a diagnostic and imaging tool long ruled potentially unsafe and off-limits for more than 2 million Americans who currently have a surgically implanted cardiac device.
Researchers have launched the first government-sponsored study to measure the effectiveness of a Web- and community-based home test kit for common sexually transmitted diseases, such as Chlamydia and gonorrhea.
Two of the most cited names in science say that one of the most promising roles that newly discovered cancer genes may perform is in early detection, which likely will be as important as new treatments.
Scientists are calling for simultaneous evaluation of both genetic and epigenetic information in the search to understand contributors to such common diseases as cancer, heart disease and diabetes. The scientists provide a framework for systematically incorporating epigenetic information into traditional genetic studies.
Johns Hopkins researchers report that once a growing nerve "tastes" a certain protein, it loses its "appetite" for other proteins and follows the tasty crumbs to reach its final destination.
Finding cancer in a tiny drop of body fluid containing relatively few cells now may be possible with a new method of analyzing multiple genes in small samples of DNA, the cellular building blocks of our genetic code.
Results of laboratory experiments by Johns Hopkins scientists suggest it may be possible to "educate" the immune system to recognize rather than destroy human embryonic stem cells.
In experiments with fruit flies, researchers have discovered how a key light-detecting molecule in the eye moves in response to changes in light intensity.
At the XV International AIDS Conference in Bangkok today, the Bill & Melinda Gates Foundation announced a $44.7 million grant to support the Consortium to Respond Effectively to the AIDS-TB Epidemic.
By studying rodent models of the relatively rare inherited form of Lou Gehrig's disease and tissue samples from a patient with the condition, scientists have discovered the first evidence that damage to nerve cell powerhouses is directly responsible for these cells' death.
1) Two common antiretrovirals are equally effective, but one has fewer side effects; 2) Up-front cost for treating an HIV-infected patient in Africa is $30 USD per visit.
In animal studies, scientists at Johns Hopkins have developed what is believed to be the first successful gene therapy that mimics the action of calcium channel blockers, agents widely used in the treatment of heart diseases, including angina, arrhythmias, hypertension and enlarged heart.
A blood test that measures food-specific allergy antibodies can be used to help pediatric allergists with the difficult decision of when to reintroduce a food that a child has been allergic to, say researchers.
Scientists have created a new surgical technique that in extensive animal studies is safe and may improve even further the benefit of minimally invasive surgery by leaving the abdominal wall intact.
More than half of all parents say they always limit what their children see on TV, but almost three-quarters admit their children still see televised violence at least once a week.
With a $5 million, five-year federal grant, The School of Medicine is establishing what is believed to be the first university-based research center devoted to studying epigenetics, setting the stage for learning as much about our epigenetics as the Human Genome Project taught about our genetic sequence.
By studying the genes of a German child born with unusually well developed muscles, an international research team has discovered the first evidence that the gene whose loss makes "mighty mice" also controls muscle growth in people.
Researchers at the University of Michigan, Johns Hopkins and the Institute of Bioinformatics in India have discovered a gene-expression "signature" common to distinct types of cancer, renewing hope that a universal treatment for the nation's second leading killer might be found.
Researchers report finding a key signal in mice that tells stem cells to commit to becoming fat cells.
A new approach to therapy can avoid most of the debilitating effects of preparing for critical, postsurgical treatment for patients with thyroid cancer, according to an international study led by researchers from Johns Hopkins and the University of Pisa.
A highly lauded and widely adopted program that relies on home visits by paraprofessionals to promote effective parenting in families at risk of child abuse succeeded in building trust, but neither prevented abuse nor reduced known risk factors, according to results of a study.
Johns Hopkins Kimmel Cancer Center clinicians were among those at leading institutions that have completed a three-year international study showing that docetaxel, a drug made from yew tree needles, decreases the chance of dying by 24 percent in advanced-stage prostate cancer patients resistant to hormone therapy.
Recent clinical studies led by Johns Hopkins Kimmel Cancer Center researchers have found that a drug called atrasentan reduces the risk by 20 percent that cancer will progress in men with advanced hormone-resistant prostate cancer.
Researchers from the Johns Hopkins Kimmel Cancer Center, Indiana University and the University of Michigan have found that some women have a gene mutation that may decrease the effectiveness of tamoxifen, a commonly used breast cancer drug.
A Gynecologic Oncology Group study has revealed that pathologists who evaluate uterine biopsies disagree 60 percent of the time on whether the specimens contain cancerous cells.
Bone marrow stem cells, when exposed to damaged liver tissue, can quickly convert into healthy liver cells and help repair the damaged organ, according to new research from the Johns Hopkins Kimmel Cancer Center.
Johns Hopkins researchers report that four critical components of cells' protein-building machine don't do what scientists had long assumed.
Researchers report that more than half of ovarian cancer surgeries in Maryland are done by surgeons who perform the operation only once or at most four times a year. Previous studies have shown that poor outcomes after such surgery are twice as likely in hospitals with ovarian cancer surgery volumes of fewer than 10 cases per year.
In a national survey of practicing physicians, the majority reported that their training in chronic care medicine was too thin overall to meet the demands of their practices. Nearly two-thirds felt poorly trained in skills related to the care of chronically ill patients.
Scientists say they have evidence that abnormally short telomeres - the end-caps on chromosomes that normally preserve genetic integrity -appear to play a role in the early development of many types of cancer.
Scientists have discovered mutations in a family of genes linked to more than a quarter of colon cancers, as well as several other common cancers including breast and lung. Their research reveals more options for creating personalized therapies tailored to counteract mutated gene pathways present in individual tumors.
Johns Hopkins scientists have transformed a common "jumping gene" found in the human genome into one that moves hundreds of times more often than normal in mouse and human cells.
In experiments with fruit flies, Johns Hopkins scientists have restored the insect's sperm-making stem cells by triggering cells on the way to becoming sperm to reverse course.
Johns Hopkins researchers have developed the basis of an inexpensive, simple urine test that identifies impending kidney failure or rejection following transplant surgery.
Oxygen delivered through the nose may improve poor vision caused by diabetic macular edema, fluid buildup in the part of the eye responsible for central vision, according to a pilot study by scientists at Johns Hopkins and the National Eye Institute.
Using genetically engineered mice, researchers have identified a gene that functions as a cancer-causing gene (or oncogene) and may play a key role in the development of leukemia and other cancers in children and adults.
By comparing the genomes of an alga, a weed and humans, a team of researchers has identified a new gene behind Bardet-Beidl syndrome (BBS), a complex condition marked by learning disabilities, vision loss and obesity.
A team that included a trauma surgeon renowned for his treatment of gunshot victims has found that exposing at-risk children and teenagers to grisly videos and photos of these patients' wounds can significantly change the youths' beliefs about the value and consequences of aggression.
1) High blood testosterone levels associated with increased prostate cancer risk; 2) Obese men may have increased risk for prostate cancer recurrence after surgery; 3) American Urological Association awards highest honor to Urology Chairman at Johns Hopkins
A new study finds that many hospitalized patients prefer visits from their own physician to those of the physicians on duty, even when those "visits" are virtual "telerounds."
Peanut allergy sufferers and their parents take note: a study finds that most soaps and household cleaners will remove enough peanut allergen from hands and dining surfaces at home and in schools to prevent an attack.
Once expected to die in early childhood, children born with HIV are now surviving into their teens and early adulthood. But it's also likely they will develop drug resistance. Researchers say that with careful planning and adherence to treatment plans, these patients can stay healthy.
The development of an aggressive but rare type of esophageal cancer in African-Americans may follow a different path than the same disease in whites, and is more likely to be fatal, according to results of a study.
The combination of real-time PET and CT is a highly sensitive tool for identifying non-small cell lung cancer and can assist in identifying patients whose cancer has not yet spread to lymph nodes, according to results of a study.
In experiments with rodents, Johns Hopkins scientists have used properly directed stem cells to successfully overcome what is thought to be a basic hurdle in restoring function to severely damaged central nervous systems -- getting new motor neurons to migrate through the spinal cord.
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