Despite promising evidence that a gene closely linked to schizophrenia would be found on human chromosome number 1, an international team of scientists who scoured the chromosome in more than 1,900 patients concludes it isn't there.
Young men who quickly react to stress with anger are at three times the normal risk of developing premature heart disease, according to a Johns Hopkins study of more than 1,000 physicians.
The Johns Hopkins Hospital is one of eight worldwide sites chosen to conduct a Phase 3 clinical trial on the treatment of uterine fibroids using magnetic resonance imaging (MRI)-guided high intensity focused ultrasound.
Author William Styron and pediatric neurosurgeon Benjamin Carson, M.D., will be featured speakers at the annual symposium sponsored by the Johns Hopkins Affective Disorders Clinic and DRADA, the Depression and Related Affective Disorders Association. Noted Hopkins psychiatrist, writer and MacArthur Prize winner Kay Redfield Jamison will also speak.
Hopkins cancer researchers have identified a new genetic culprit-with dietary links-in the initiation of prostate cancer.
Heart attack patients may be better off with balloon angioplasty to open blocked blood vessels than with clot-busting drugs, even if their hospital lacks a cardiac surgery program, according to a Johns Hopkins-led study.
In experiments with fat cells, Johns Hopkins scientists have discovered direct evidence that a build-up of sugar on proteins triggers insulin resistance, a key feature of most cases of diabetes.
For what is believed to be the first time, scientists have unraveled the complicated genetics of an inherited intestinal disease, opening the door to revealing complete genetic pictures of other complex diseases. The findings underscore non-coding genetic regions' importance in disease.
The best of the best. The cream of the crop. Cliches may accurately describe the winners of this year's 25th annual Young Investigators' Day awards at The Johns Hopkins University School of Medicine, but their work is anything but run of the mill.
A lot has happened since 1978. Kings have fallen, conventional wisdoms have been squashed, villains slain and heroes brought to light. And that's just in laboratory dishes. April 11 marks the twenty-fifth annual Young Investigators' Day at Johns Hopkins.
This information tip sheet highlights research news from the Kimmel Cancer Center at Johns Hopkins that are the subject of presentations at the annual meeting of the American Association of Cancer Research.
Glaucoma is the leading cause of blindness among U.S. Hispanics, while cataracts are the leading cause of visual impairment, according to results of a national study led by Johns Hopkins researchers.
The anti-inflammatory drug sulindac may not have the colon cancer prevention properties once hoped for, say Johns Hopkins Kimmel Cancer Center researchers. Results of a four-year study show that sulindac did not prevent precancerous growths, called polyps, in young patients with a hereditary form of colon cancer. The drug may still have benefit in reducing polyps in older patients.
For the tenth straight year, the National Institutes of Health annual summary of grants to medical schools ranks The Johns Hopkins University School of Medicine the top recipient of federal research dollars in the United States.
Two Johns Hopkins studies have strongly affirmed the value of treadmill exercise tests in diagnosing heart disease in middle-aged women and men before symptoms occur.
A team of Hopkins scientists has greatly advanced the science of penile erection, showing for the first time the mechanism for continued production of nitric oxide that maintains an erection over time.
A diet rich in soy appears to decrease inflammation-induced pain in rats, according to a study by Johns Hopkins researchers.
The Phoebe R. Berman Bioethics Institute at The Johns Hopkins University has received a three-year, $9.9M grant from the Pew Charitable Trusts to establish the Genetics and Public Policy Center in Washington, D.C. The center's first initiative will focus on ethical and public policy issues related to genetics and human reproduction.
Researchers at Johns Hopkins and 54 eye-care centers across North America have found two competing methods of correcting a mild form of children's amblyopia -- pejoratively called "lazy eye"-- are equally effective in correcting the vision disorder.
After almost 10 years of research with cells and animals to learn what makes a certain enzyme act as a "bad guy" in the progressive and fatal disease amyotrophic lateral sclerosis (ALS), Johns Hopkins scientists report that a leading candidate -- copper -- is off the hook.
The recent decision by U.S. Attorney General John Ashcroft to challenge the legality of Oregon's physician-assisted suicide law has re-ignited debate over this thorny issue. In response to the fallout after Ashcroft's decision, the Phoebe R. Berman Bioethics Institute at Johns Hopkins will sponsor a two-part debate about whether the Oregon law should be allowed to stand, as part of the Harvey M. Meyerhoff Lectures on Ethics and the End of Life.
Instead of years of allergy shots that may only marginally reduce their symptoms, "hayfever" victims may soon be closer to getting substantially more effective control of their allergic problems with just six shots in six weeks.
Patients and physicians with questions about digestive diseases can turn to the newly launched Johns Hopkins Gastroenterology and Hepatology Resource Center, www.hopkins-gi.org, for answers.
Imagine dropping a bowl of spaghetti. That's what AVMs (arteriovenous malformations) look like in the brain -- dense clusters of twisting and turning blood vessels that look more like a wrestling match among a hundred small snakes than part of the circulatory system. Many patients don't know they have one. Some have crippling headaches. For the more unfortunate, the AVM ruptures, causing brain damage or death.
People with the rare bone disease oncogenic osteomalacia have the worst of both worlds. It may take years before their condition -- marked by tiny, noncancerous tumors that hide out and wreak havoc on the skeletal system -- is correctly diagnosed. Then more years can go by before physicians can precisely locate the tumors and remove them. Meanwhile, patients suffer debilitating bone pain, fractures and muscle weakness.
For mice genetically altered to get fat, knocking out a particular gene keeps them both leaner and healthier, Johns Hopkins School of Medicine scientists report.
Using genetically engineered mice, Johns Hopkins and other scientists have shown for the first time that a single kind of cell in the retina seems to detect light for the body's internal clock and for the pupil.
Expanding their studies of an experimental compound that causes dramatic weight loss and appetite suppression in mice, Johns Hopkins researchers now report that lean mice rapidly adjust to daily doses of the drug and get their appetites back, while their obese counterparts do not.
Hypoglycemia, or low blood sugar, may have a significant effect on activity patterns in a newborn's brain, say researchers at Johns Hopkins Children's Center and St. Christopher's Hospital for Children in Philadelphia.
Persistent mistrust of doctors and hospitals, and religious misconceptions may explain why more people, especially minorities, do not become blood and organ donors, Johns Hopkins researchers report.
In experiments with genetically engineered mice, Johns Hopkins researchers have found an "off-switch" for systemic inflammation, the body's overall response to injury and infection. The findings may have implications for treatment of inflammation-related diseases in humans, from autoimmune disorders to atherosclerosis, the researchers say.
Scientists at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins have developed a safe and reliable stool test that can detect the earliest, curable stages of colon cancer.
1) Johns Hopkins scientists find brain's nose plug; 2) Eat your veggies: indirect anti-oxidants provide long-term protection; 3) Tether for water channels found: may impact research on brain swelling.
A team of scientists led by drug maker Wyeth-Ayerst and Johns Hopkins have engineered and tested a new rat model of Lou Gehrig's disease they say is far easier to work with than earlier mouse models.
African Americans and Asians have a worse outcome than white Americans and Hispanics after liver transplantation, both in terms of graft rejection and survival.
The crucial movement of water across cell membranes in the lung was long thought to be a passive process, but a team of researchers from Hopkins and the University of Aarhus in Denmark have demonstrated that a specific protein plays a major role. The discovery may lead to new treatments for some forms of asthma, pneumonia and pulmonary edema or swelling.
Genetically and physically, male babies born with a condition called "micropenis" are more likely to achieve psychological and sexual well-being in adulthood if raised male, according to a new study by researchers at Johns Hopkins and three other centers.
Preventing HIV-infected pregnant women from transmitting the virus to their newborns has long been a major concern for obstetricians. As such, many doctors continue to debate the benefits of elective Caesarian section as a way to protect the infant.
Women with thyroid disease are more likely to give birth to babies with heart, brain and kidney defects even if the thyroid function tests are normal during the pregnancy, according to new research from Johns Hopkins.
The U.S. Food and Drug Administration announced its approval of brain stimulation therapy to relieve some of the debilitating symptoms of Parkinson's Disease, a progressive and degenerative movement disorder.
"Klotho," a gene named for the Greek Fate purported to spin the thread of life, contributes to life expectancy in humans, according to a team led by Johns Hopkins scientists.
Using neat genetic tricks with fruit flies, scientists from Johns Hopkins School of Medicine have found the key signal that allows a group of normally stationary cells in the ovary to travel.
The genetic underpinnings of panic disorder and manic depressive (bipolar) illness have long eluded scientists. Now, researchers at Johns Hopkins studying the inheritance patterns of these conditions have concluded that they probably are not separate diseases at all, but different forms of a shared and complex biological condition.
Scientists at Johns Hopkins and three other centers have found that defects in GNAS1, a hormone sensitivity gene, are responsible for progressive osseus heteroplasia (POH), a disease that causes rice-size bone fragments to spontaneously form under the skin and inside internal organs. The finding also represents a major step forward in identifying the genes responsible for normal bone formation in children and adults, a process that has largely mystified scientists.
Researchers at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins have genetically altered human blood stem cells to selectively activate genes in developing immune cells. Results of the research in mice shows it's possible to transfer genes into stem cells and activate the immune system to fight cancer and enhance transplantation.
Johns Hopkins scientists report success in figuring out how an experimental compound prevents mice from recognizing that it's time to eat, profoundly suppressing appetite and causing weight loss.
Combining a decade of research advances, scientists have implemented a new method that essentially searches the entire yeast genome in an instant, looking for what the genes do rather than what they look like, say the researchers from Johns Hopkins and elsewhere.
Researchers at Johns Hopkins Children's Center and St. Vincent de Paul's Hospital in Paris have learned that bone defects associated with classic bladder exstrophy are more extensive than previously thought. Their findings will enable surgeons to better correct these bone defects that cause the bladder to develop outside of the body.
Suppressing the immune system is one way to treat autoimmune diseases, frustrating conditions in which the body's tissues are attacked by "friendly fire." But a new study shows that such blanket defenses are probably not the best way, say scientists from The Johns Hopkins University School of Medicine.
Glaucoma is more common among U.S. Hispanics than previously thought and is the leading cause of blindness in this growing ethnic group, according to a national study led by Johns Hopkins researchers.
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