LJI Associate Professor Sonia Sharma, Ph.D., is an expert in using unbiased, genome-scale approaches to unravel innate immunity, the body’s early immune response to microbial pathogens and neoplastic cells. Innate immunity has also been implicated as a common causal factor in many inflammatory, allergic and autoimmune diseases. Dr. Sharma integrates cutting-edge genetics, biochemistry, cell biology, computational and translational approaches to define the key genetic mechanisms regulating cellular innate immunity and determine how they impact human health and disease.

Dr. Sharma has an outstanding record of research accomplishments, including high impact discoveries published in top scientific journals. Her work has made her an internationally recognized expert in the use of high throughput, genome scale approaches, in particular RNA interference and CRISPR/Cas9, to dissect complex cellular signaling pathways and questions of immunological relevance. Her use of these technologies is a powerful tool that can be applied to any cellular pathway or disease process.

Dr. Sharma also directs the La Jolla Institute for Immunology's Sex-Based Differences in the Immune System Initiative, which aims to shed light on why many diseases affect men and women differently.

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“It’s become clear that sex-specific differences in the immune system are intimately tied to certain disease outcomes," says Dr. Sharma.

- Learning from men. Learning from women.

“Can we turn this observation into a therapy designed to make cancer immunotherapy better?” says Dr. Sharma

- Sonia Sharma zeros in on metabolites

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