Feature Channels: Stem Cells

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Released: 14-Jun-2022 12:00 PM EDT
The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition
Preprints

Pei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang, Haibo Xiao

Released: 14-Jun-2022 12:00 PM EDT
Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
Preprints

James A. Watson, Raphaël Pantier, Uma Jayachandran, Kashyap Chhatbar, Beatrice Alexander-Howden, Valdeko Kruusvee, Michal Prendecki, Adrian P Bird, Atlanta G. Cook

Released: 13-Jun-2022 12:00 PM EDT
Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids
Preprints

Thomas L Li, Yuxin Liu, Csaba Forro, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P Pasca

Released: 13-Jun-2022 12:00 PM EDT
Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory
Preprints

Khadar Abdi, Ramona Rodriguez, William C Wetsel, Michelle E Arlotto, Robert W McGarrah, Phillip J White

Released: 13-Jun-2022 12:00 PM EDT
Generation of Cerebral Organoids with Enriched Cortical Cellular Diversity and Outer Radial Glial Cell Identity from Human Pluripotent Stem Cells
Preprints

Yechiel Elkabetz, Sneha Arora, Anastasios Balaskas, Amèlia Aragonés Hernández, Daniel Rosebrock

Released: 13-Jun-2022 12:00 PM EDT
ΔNp63α Transcriptionally Represses p53 Target Genes Involved in the Radiation-Induced DNA Damage Response
Preprints

Ken-Ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Sakai

Released: 12-Jun-2022 12:00 PM EDT
A Development-Inspired Niche for Homeostatic Human Mini-Intestines
Preprints

Charlie J Childs, Emily M Holloway, Caden W Sweet, Yu-Hwai Tsai, Angeline Wu, Joshua Wu, Oscar Pellon Cardenas, Meghan M Capeling, Madeline Eiken, Rachel Zwick, Brisa Palikuqi, Coralie Trentesaux, Charles Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, Gray Camp, Jonathan Z Sexton, Ophir D Klein, Michael P Verzi, Jason J Spence

Released: 12-Jun-2022 12:00 PM EDT
Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture
Preprints

Ester Gil Vasquez, Nadia Nasreddin, Gabriel N Valbuena, Eoghan J Mulholland, Hayley L Belnoue-Davis, Holly Eggington, Ryan O Schenck, Valerie M Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R M Lannagan, Dustin J Flanagan, Arafath K Najumudeen, Sulochana Omwenga, Amy M B McCorry, Alistair Easton, Viktor H Koelzer, James E East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D Campbell, Maurice B Loughrey, Philip D Dunne, Petros Tsantoulis, David J Huels, Sabine Tejpar, Owen Sansom, Simon J Leedham

Released: 12-Jun-2022 12:00 PM EDT
Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey
Preprints

Ravi Jagasia, Charlotte Bon, Soren V. Rasmussen, Solveig Badillo, Disa Tehler, Daniele Buchy, Marco Berrera, Megana Prasad, Marco Terrigno, Nikhil J. Pandya, Veronica Costa, Congwei Wang, Lykke Pedersen, Meghan T Miller, Kamille Dumong Erichsen, Lars Joenson, Joerg Hipp, Azad Bonni, Lutz Mueller, Annamaria Braendli-Baiocco, Thomas Kremer, Erich Koller, Marius Hoener

Released: 12-Jun-2022 12:00 PM EDT
Antiviral Therapy Defiant Polyviral Retinitis Post Hematopoietic Allogeneic Stem Cell Transplant
Preprints

Nadia Gabarin, Mili Roy, Alexander J. Kaplan, Shariq Haider, Dina Khalaf

Released: 11-Jun-2022 12:00 PM EDT
A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target
Preprints

Ana Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J Hope

7-Jun-2022 9:00 AM EDT
Stem-Cell Based Therapy Shows Promise in Treating High-Risk Type 1 Diabetes
Endocrine Society

An investigative stem cell-based therapy called PEC-Direct, designed to act as a replacement pancreas, has the potential to provide blood sugar control in patients with high-risk type 1 diabetes, suggests a clinical study presented Saturday, June 11 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.

Newswise: Pediatric Urologist Dr. Anthony Atala to Receive 2022 Jacobson Innovation Award of the American College of Surgeons for Pioneering Work in Regenerative Medicine
Released: 10-Jun-2022 11:30 AM EDT
Pediatric Urologist Dr. Anthony Atala to Receive 2022 Jacobson Innovation Award of the American College of Surgeons for Pioneering Work in Regenerative Medicine
American College of Surgeons (ACS)

The Jacobson Innovation Award is an international surgical honor that recognizes living surgeons who are innovators of a new development or technique in any field of surgery. It is made possible through a gift from Julius H. Jacobson II, MD, FACS, and his wife Joan. Dr. Jacobson is a general vascular surgeon known for his pioneering work in the development of microsurgery. This year's recipient, Dr. Anthony Atala, is a pediatric urologist, researcher, professor, and mentor who is renowned for developing foundational principles for regenerative medicine research, which holds great promise for people who require tissue substitution and reconstruction.

Released: 9-Jun-2022 12:00 PM EDT
Hyaluronic acid biosynthesis promotes an invasive, stem-like cancer cell phenotype by broadly altering metabolism
Preprints

Adrian Adwait Shimpi, Matthew Lee Tan, Michael Vilkhovoy, David Dai, Ladeidra Monet Roberts, Joe Chin-Hun Kuo, Lingting Huang, Jeffrey Varner, Matthew J Paszek, Claudia Fischbach

Released: 9-Jun-2022 12:00 PM EDT
The Korean Undiagnosed Diseases Program Phase I: Expansion of the Nationwide Network and the Development of Long-term Infrastructures
Preprints

Soo Yeon Kim, Seungbok Lee, Hyewon Woo, Young Jun Ko, Youngkyu Shim, Soojin Park, Se Song Jang, Byung Chan Lim, Jung Min Ko, Ki Joong Kim, Anna Cho, Hunmin Kim, Hee Hwang, Ji Eun Choi, Man Jin Kim, Jangsup Moon, Moon-Woo Seong, Sung Sup Park, Sun Ah Choi, Ji Eun Lee, Young Se Kwon, Young Bae Sohn, Jon Soo Kim, Won Seop Kim, Yun Jeong Lee, Soonhak Kwon, Young Ok Kim, Hoon Kook, Yong Gon Cho, Chong Kun Cheon, Ki-Soo Kang, Mi-Ryoung Song, Hyuk-Jin Cha, Hee-Jung Choi, Yun Kee, Seung Tae Baek, Murim Choi, Jong-Hee Chae, Dong-Sung Ryu

Released: 9-Jun-2022 12:00 PM EDT
Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimer's Disease
Preprints

Yubing Liu, Bensun Cambell Fong, Richard A Harris, Marie-Michelle McNicoll, Amaal A Abdi, Jacob B Cuthbert, David P Cook, Daniel Figeys, Jing Wang, Barbara C Vanderhyden, Ruth S Slack

Newswise: First-of-its-Kind Stem Cell and Gene Therapy Highlighted at Annual Stem Cell Meeting
Released: 9-Jun-2022 11:35 AM EDT
First-of-its-Kind Stem Cell and Gene Therapy Highlighted at Annual Stem Cell Meeting
Cedars-Sinai

Investigators from Cedars-Sinai will present the latest novel stem cell and regenerative medicine research at the International Society for Stem Cell Research (ISSCR) Annual Meeting, which is being held in person and virtually June 15-19 in San Francisco.

Released: 8-Jun-2022 2:05 AM EDT
Double Agents: How Stomach Stem Cells Change Allegiance Upon Injury
Institute of Molecular Biotechnology

The interest of scientists in adult stem cells resides in their ability to self-renew indefinitely and differentiate into all cell types making up the organ where they reside.

Released: 7-Jun-2022 5:05 PM EDT
Stem Cells Either Overproduce or Underproduce Brain Cells in Autism Patients
Rutgers University-New Brunswick

Analyzing brain stem cells of patients with autism spectrum disorder (ASD), Rutgers scientists have found evidence of irregularities in very early brain development that may contribute to the neuropsychiatric disorder.

Released: 7-Jun-2022 12:00 PM EDT
Effect of Electrical Stimulation on Spinal Cord Injury: In Vitro and In Vivo Analysis
Preprints

Woo-Seok Bang, Inbo Han, Seul-Ah Mun, Dae-Chul Cho, Sang-Woo Lee, Byoung-Joon Kim, Chi Heon Kim, Hyuk Choi, Kyoung-Tae Kim

Released: 6-Jun-2022 12:00 PM EDT
Expression of stem cell biomarkers Bmi1 and KLF4 in osteosarcoma and its clinical significance
Preprints

Shiwei Chen, Taiyong Wu, Simin Ning, Zhuangzhuang Wu, Wenxuan Jin, Pengcui Li

Released: 6-Jun-2022 12:00 PM EDT
Continuous Indexing of Fibrosis (CIF): Improving the Assessment and Classification of MPN Patients
Preprints

Hosuk Ryou, Korsuk Sirinukunwattana, Alan Aberdeen, Gillian Grindstaff, Bernadett Stolz, Helen Byrne, Heather A. Harrington, Nikolaos Sousos, Anna L. Godfrey, Claire N. Harrison, Bethan Psaila, Adam J. Mead, Gabrielle Rees, Gareth D.H. Turner, Jens Rittscher, Daniel Royston

Released: 6-Jun-2022 12:00 PM EDT
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway
Preprints

Guoqing Wang, Xiangpeng Shen, Xiangkong Song, Ningfen Wang, Xuewen Wo, Yonglei Gao

Released: 5-Jun-2022 12:05 PM EDT
Improved Progression-Free Survival in Multiple Myeloma Patients Following Three-Drug Therapy with Autologous Stem Cell Transplant
Dana-Farber Cancer Institute

Patients with multiple myeloma who have been treated with a three-drug combination therapy have a growing number of choices for subsequent treatment. Results of a new study led by researchers at Dana-Farber Cancer Institute can help patients and their physicians weigh benefits and risks of each option.

Released: 5-Jun-2022 12:00 PM EDT
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Preprints

Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Han Sun, Antje K Rottner, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Weslowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders Larsson, Patrick E MacDonald, Benjamin Davies, Marcel Den Hoed, Anna L Gloyn

Released: 5-Jun-2022 12:00 PM EDT
PRC2 clock: a universal biomarker of aging and rejuvenation
Preprints

Mahdi Moqri, Andrea Cipriano, Daniel Nachun, Tara Murty, Guilherme De Sena Brandine, Sajede Rasouli, Andrei Tarkhov, Karolina A Aberg, Edwin Jcg Van Den Oord, Wanding Zhou, Andrew D Smith, Crystal Mackall, Vadim N Gladyshev, Steve Horvath, Michael Snyder, Vittorio Sebastiano

Released: 5-Jun-2022 12:00 PM EDT
Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during Aging
Preprints

Yue Wu, Bibo Zhu, Ruixuan Zhang, Nick P. Goplen, Xiaochen Gao, Harish Narasimhan, Ao Shi, Yin Chen, Ying Li, Haidong Dong, Thomas J. Braciale, Jie Sun

Released: 4-Jun-2022 12:00 PM EDT
Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss
Preprints

Jacqueline A Larouche, Emily C Wallace, Bonnie D Spence, Scott A Johnson, Mangesh Kulkarni, Eric Buras, Bryan N Brown, Stephen F Badylak, Carlos Andres Aguilar

Released: 3-Jun-2022 12:00 PM EDT
A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry
Preprints

Austin B. Keeler, Amy L. Van Deusen, Irene Cheng, Corey M. Williams, Sarah M. Goggin, Ashley K. Hirt, Shayla A. Vradenburgh, Kristen I. Fread, Emily A. Puleo, Lucy Jin, O. Yipkin Calhan, Christopher D Deppmann, Eli R. Zunder

Released: 3-Jun-2022 12:00 PM EDT
Human hematopoietic stem cell vulnerability to ferroptosis
Preprints

Jiawei Zhao, Yuemeng Jia, Dilnar Mahmut, Amy Anderson Deik, Sarah Jeanfavre, Clary B. Clish, Vijay G. Sankaran

Released: 3-Jun-2022 12:00 PM EDT
Reconstituting human somitogenesis in vitro
Preprints

Yoshihiro Yamanaka, Kumiko Yoshioka-Kobayashi, Sofiane Hamidi, Sirajam Munira, Kazunori Sunadome, Yi Zhang, Yuzuru Kurokawa, Ai Mieda, Jamie L. Thompson, Janet Kerwin, Steven Lisgo, Takuya Yamamoto, Naomi Moris, Alfonso Martinez-Arias, Taro Tsujimura, Cantas Alev

Released: 3-Jun-2022 12:00 PM EDT
Anatomical distribution of Cancer Stem Cells between Enhancing Nodule and FLAIR hyperintensity in supratentorial Glioblastoma: time to recalibrate the surgical target?
Preprints

Roberto Altieri, Giuseppe Broggi, Francesco Certo, Daniela Pacella, Giacomo Cammarata, Massimiliano Maione, Marco Garozzo, Davide Barbagallo, Michele Purrello, Rosario Caltabiano, Gaetano Magro, Giuseppe Barbagallo

Released: 3-Jun-2022 12:00 PM EDT
A genome-wide screen reveals new regulators of the 2-cell-like cell state
Preprints

Pierre-Antoine Defossez, Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, Fumihito Miura, Laure Ferry, Olivier Kirsh, Anaelle Azogui, Kohsuke Yamaguchi, Marthe Laisné, Cécilia Domrane, Frédéric Bonhomme, Arpita Sarkar, Marine Delagrange, Bertrand Ducos, Gael Cristofari, Takashi Ito, Maxim Greenberg

Released: 3-Jun-2022 12:00 PM EDT
Expression Of CD44+/CD24-, RAD6 and DDB2 On Chemotherapy Response In Ovarian Cancer: A Prospective Flow Cytometry Study
Preprints

Unedo Hence Markus Sihombing, Andrijono Andrijono, Gatot Purwoto, Supriadi Gandamihardja, Alida R. Harahap, Primariadewi Rustamadji, Aria Kekalih, Retno Widyawati, Dzicky Rifqi Fuady

Released: 3-Jun-2022 12:00 PM EDT
Regulation of human trophoblast gene expression by endogenous retroviruses
Preprints

Miguel Branco, Jennifer Frost, Samuele Amante, Hiroaki Okae, Eleri Jones, Brogan Ashley, Rohan Lewis, Jane Cleal, Takahiro Arima, Tania Maffucci, Matthew Caley

Released: 3-Jun-2022 12:00 PM EDT
Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons
Preprints

Emiliano Hergenreder, Yana Zorina, Zeping Zhao, Hermany Munguba, Elizabeth L Calder, Arianna Baggiolini, Andrew P Minotti, Ryan M Walsh, Conor Liston, Joshua Levitz, Ralph Garippa, Shuibing Chen, Gabriele Ciceri, Lorenz Studer

Released: 3-Jun-2022 12:00 PM EDT
Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells
Preprints

Takashi Satake, Shingo Komura, Hitomi Aoki, Akihiro Hirakawa, Yuuki Imai, Haruhiko Akiyama

Released: 3-Jun-2022 12:00 PM EDT
An epigenetic barrier sets the timing of human neuronal maturation
Preprints

Gabriele Ciceri, Hyunwoo Cho, Meghana Kshirsagar, Arianna Baggiolini, Kelly A Aromolaran, Ryan M Walsh, Peter A Goldstein, Richard P Koche, Christina S Leslie, Lorenz Studer

Newswise: Functional Microglia Derived From Human Pluripotent Stem Cells Empower Retinal Organ
Released: 2-Jun-2022 5:05 PM EDT
Functional Microglia Derived From Human Pluripotent Stem Cells Empower Retinal Organ
Science China Press

This study is led by prof. Jin (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University).



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