Feature Channels: Liver Disease

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Researchers at Henry Ford Health System, as part of a national hepatitis C collaborative, report that patients with chronic hepatitis C who are treated with direct-acting antiviral medicines are less likely to be hospitalized or seek emergency care for liver and non-liver related health issues. The study, published online in Clinical Infectious Diseases, underscores the extraordinary effect of these newer antivirals, which have been shown to cure hepatitis C in 98 percent of patients who take them. Patients are said to be cured when the virus is no longer detectable in their blood.

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Pacientes com cirrose relacionada ao consumo de álcool (ALC) têm piores resultados após receberem alta do tratamento intensivo, em comparação aos pacientes com cirrose associada a outras causas, de acordo com a nova pesquisa da Mayo Clinic.

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Los resultados de los pacientes con cirrosis por alcohol (ALC, por sus siglas en inglés) después de recibir el alta de cuidados intensivos son peores que los de los pacientes con cirrosis por otras causas, dice un nuevo estudio de Mayo Clinic.

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根据妙佑医疗国际(Mayo Clinic) 的新研究，相比其他病因的肝硬化患者，酒精性肝硬化（ALC）患者从重症监护室出院后的恢复结局较差。

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Mayo Clinic researchers have developed a new scoring system to help health care professionals predict the 30-day mortality risk for patients with alcohol-associated hepatitis, and the tool appears to more accurately identify patients at highest risk of death and those likely to survive.

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A new study at Children’s Hospital Los Angeles independently verified the value of a system that assesses hepatoblastoma risk in children. Hepatoblastoma is a rare childhood liver cancer, usually seen within the first three years of a child’s life with 50 to 70 cases occurring in the U.S. each year.

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InSphero AG, the pioneer in 3D cell-based assay and organ-on-chip technology, today announced the strengthening of its Scientific Advisory Board (SAB) with the appointment of Professor Nikolai Naoumov, MD PhD.

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In new research published in Liver International, researchers at Henry Ford Health System have found that people hospitalized for alcoholic hepatitis – a life threatening liver disease fueled by alcohol use – increased a staggering 50 percent in the early months of the COVID-19 pandemic. Researchers said the role of gender and race had no meaningful impact on the spike in admissions.

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An imprinted gene associated with development of non-alcoholic fatty liver disease (NAFLD) is switched on in mice who nurse from mothers with metabolic syndrome, even when those mice are not biologically related.

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Miral Sadaria Grandhi, MD, surgical oncologist in the Liver Cancer and Bile Duct Cancer Program at Rutgers Cancer Institute of New Jersey and assistant professor of surgery at Rutgers Robert Wood Johnson Medical School, shares more about gallbladder and bile duct cancer.

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Diagnosed with acute liver failure and her health rapidly deteriorating, it seemed like 11-month-old Lennon would need a miracle to survive. Thanks to a team of specialists at Children’s Hospital Los Angeles, she just celebrated her third birthday.

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The February issue of AJG includes new ACG Clinical Guidelines on acute-on-chronic liver failure, the College’s first set of guidelines on a condition that is emerging as a major cause of mortality among patients with cirrhosis and CLD.

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Patients with alcohol-associated cirrhosis have poorer outcomes after ICU discharge, compared to patients with cirrhosis linked to other causes, according to new Mayo Clinic research.

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Acute liver failure (ALF) happens very quickly, with few warning signs before a child presents in the emergency room. But there are also few reliable predictors of a child’s outcome. That makes it challenging for physicians to know when it’s best to move forward with a liver transplant—and when it’s best to wait.

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A team of NUS researchers from Cancer Science Institute of Singapore has identified new pathways responsible for hepatocellular carcinoma (HCC), the most common type of primary liver cancer. The new insights could potentially improve treatment for patients.

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Physician researchers from UT Southwestern Medical Center have developed an innovative nanotherapeutic drug that prevents cancer from spreading to the liver in mice.

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The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include an anti-CD19 chimeric antigen receptor (CAR) T cell therapy to treat follicular lymphoma, targeted therapies for urothelial cancers and advanced breast cancers, understanding the tumor microenvironment and immune landscape in pancreatic cancer, a link between depression risk and androgen deprivation for prostate cancer, and the discovery of new therapeutic targets for Alzheimer’s disease, liver cancer and aggressive breast cancer.

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The American College of Gastroenterology has just released new clinical guidelines on Acute-on-Chronic Liver Failure, an emerging major cause of mortality. The ACG Media Team can connect you with the authors or outside experts who can comment on the guidelines upon request.