Dr. Anees Chagpar discusses novel agents for neoadjuvant triple-negative breast cancer (TNBC) treatment.
Dr. Chagpar can be reached at [email protected]
Anees B. Chagpar, MD, associate professor of Surgery (Oncology), director of The Breast Center at Smilow Cancer Hospital at Yale-New Haven, Yale Cancer Center, discusses novel agents for neoadjuvant triple-negative breast cancer (TNBC) treatment. TNBC represents about one-fifth of all breast cancers, Chagpar explains. Historically, it has been associated with a poor prognosis. As patients with TNBC respond well to neoadjuvant chemotherapy, there has been a number of clinical trials looking at novel agents in this subset of patients. For example, platinum-based agents seem to work well in TNBC, she says. Patients with TNBC tend to have a high rate of tumor infiltrating lymphocytes, Chagpar explains, so this is a potentially exciting target for immunotherapy. Clinical trials have shown immunotherapy works well in heavily pre-treated patients with metastatic breast cancer, and Chagpar believes an ongoing trial looking at neoadjuvant immunotherapy in early-stage TNBC has the potential to change disease management for these patients. -