Scientists Reveal How Mutations in Metabolism Can Drive Cancers

Yale Cancer Center scientists have identified mutations in metabolite-producing genes as a disruption of DNA repair. These mutation-driven “oncometabolites” may make cells more prone to developing cancer—but also more vulnerable to new cancer...
1-Jun-2020 12:15 PM EDT Add to Favorites

Study Shows Clinical Evidence of Anti-Tumor Activity in Patients with Metastatic Castration-Resistant Prostate Cancer

Results of a Phase I clinical trial conducted by researchers at the Yale Cancer Center have shown that ARV-110, an androgen receptor PROTAC® protein degrader, demonstrates anti-tumor responses in patients with metastatic castration-resistant...
29-May-2020 8:00 AM EDT Add to Favorites

Study Shows Profound Benefit with Targeted Therapy for Patients with Early Stage NSCLC

According to findings led by researchers at Yale Cancer Center, treatment with the targeted therapy osimertinib following surgery significantly improves disease-free survival (DFS) in patients with early-stage, non-small cell lung cancer (NSCLC)...
28-May-2020 5:00 PM EDT Add to Favorites

Study Demonstrates Impact of Both Inherited and Acquired Mutations on Cancer

The common belief that tumors arise via activation of a few genes that “drive” cancer development is unsupported by a widespread investigation into those genes and others in three large patient genetic databases, according to a study led by Yale...
14-May-2020 2:45 PM EDT Add to Favorites

Study Shows Immunotherapy Prior to Surgery May Help Destroy High-Risk Breast Cancer

A new study led by Yale Cancer Center (YCC) researchers shows women with high-risk HER2-negative breast cancer treated before surgery with immunotherapy, plus a PARP inhibitor with chemotherapy, have a higher rate of complete eradication of cancer...
27-Apr-2020 9:00 AM EDT Add to Favorites

Yale Cancer Center Announces Hematology Leadership Appointments

Yale Cancer Center announces the appointments of Thomas Prebet, M.D., Ph.D., as Disease Aligned Research Team (DART) Leader for Myeloid Malignancies and Amer Zeidan, MBBS, as Director of the Hematology Early Therapeutics Program.
20-Apr-2020 8:35 AM EDT Add to Favorites

Study points to obesity as driver of pancreatic cancer

A new study led by Yale Cancer Center (YCC) researchers has demonstrated in mice that hormones released from the pancreas itself can advance pancreatic cancer — and that weight loss can stop this process in its early stages. The research was...
17-Apr-2020 8:20 AM EDT Add to Favorites

First Test Using Immunotherapy Drug to Treat Advanced Lung Cancer Shows Benefit — And Future Promise

Researchers at Yale Cancer Center (YCC) have found that use of the checkpoint inhibitor pembrolizumab can extend life with very few side effects in this patient population.
13-Apr-2020 8:40 AM EDT Add to Favorites

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