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A study by researchers at Norris Cotton Cancer Center has shown that a very sensitive computational method can be used to reveal the human immune system’s effect on cancer. The Dartmouth study was the first to perform an in-depth computational examination of how immune activity translates to prognosis in breast cancer.

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Women who visit mammography facilities with higher total interpretive volumes are more likely to benefit from screening, according to a new study published in the Journal of Medical Screening. Research shows such facilities are significantly more likely to diagnose invasive tumors with good prognoses.

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A large, randomized study at 11 U.S. hospitals including Dartmouth-Hitchcock Medical Center found that vitamin D and calcium supplements fail to protect against developing colorectal cancer.

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An unprecedented large study provides compelling evidence that long telomere length increases the risk of lung adenocarcinoma

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Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth’s Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk-associated with disease than protective.

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In the first and largest studies to examine subtle variation of imprinted gene expression and control, investigators from Dartmouth’s Norris Cotton Cancer Center, report in two papers published recently in Epigenetics on a subgroup of imprinted genes expressed in the placenta

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Accurately determining HER2 status in patients with breast cancer is a critical prognostic and predictive factor and identifies patients who may benefit from treatment with anti-HER2 therapies.

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Norris Cotton Cancer Center investigators demonstrated that a dual breast exam using MRI and Near Infrared Spectral Tomography (NIRST) is feasible and more accurate than MRI alone.

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Investigators from Dartmouth’s Norris Cotton Cancer Center harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer.

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Collagen is the most abundant protein in the human body, and investigators are uncertain how its presence affects the behavior of melanoma cells.

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Monitoring oxygen levels in human tumors growing in a mouse brain using EPR oximetry with implantable resonators provides opportunities to evaluate and optimize various strategies being developed to improve oxygen levels in the glioma.

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A team of Dartmouth investigators have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.

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Dartmouth team focuses on coming up with a practical solution that both preserves the surgical practice of inking the margins of breast cancer tumors, and allows quality imaging post-inking.

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Norris Cotton Cancer Center investigators found teens aged 15-17 years old who had ever mixed alcohol with energy drinks were four times more likely to meet the criteria for alcohol use disorder.

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Using a novel methodology of epigenetic quantitative analysis, investigators found no correlation between regulatory T cells and survival in the tumor microenvironment or blood, even when adjusting for well-known prognostic factors.

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A new randomized clinical trial has noted significant improvement in several measures among those who began palliative care early.

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Dartmouth investigators point to the shortcomings of using the word stress in a medical or scientific context and encourage bodymind therapies to treat trauma in patients with cancer.

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Dartmouth researchers identified the precise temperature that results in a distinct body-wide antitumor immune response that resists metastatic disease.

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Dartmouth study finds some portions of the female reproductive tract are more likely to be infected by HIV, particularly the ectocervix compared to the endometrium.

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A neuro-oncology research team at Dartmouth's Norris Cotton Cancer Center recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

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Uncovering cellular response to stress may provide leverage to determine how to trick undesirable cells, such as cancer or damaged cells, into dying instead of recovering from stress.

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The significance of this work is its descriptions of alternative mechanisms by which tumors move and settle in new locations.

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By engineering antibacterial enzymes, Dartmouth investigators led by Karl Griswold, PhD are using novel strategies to target the prevalent drug-resistant bacterium Staphylococcus aureus.

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The mechanism that makes fireflies glow through a process called bioluminescence can be used to study tumor response to therapy as well, researchers have found.

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Taking the focus off pain management and specific post-treatment symptoms, Norris Cotton Cancer Center researchers establish a new paradigm for working with breast cancer survivors

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Though the Academy of Pediatrics advises against the consumption of energy drinks by teens, research finds that manufacturers market the bulk of their products on TV channels that likely appeal to teens.

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The National Cancer Institute (NCI) has renewed its Cancer Center Support Grant to Norris Cotton Cancer Center (NCCC) at Dartmouth, continuing NCCC's designation as a Comprehensive Cancer Center.

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Dartmouth team uses nanomaterials to pursue a systematic study of variables in xenograft models of both breast and ovarian human cancer.

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Dartmouth bioengineers demonstrate a novel system that couples nano-engineered particles and microfluidic chips for capturing and manipulating circulating tumor cells.

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Investigators from Dartmouth's Norris Cotton Cancer Center find that the protein Pom1 possesses the ability to modify different sets of proteins to coordinate the processes of cell growth and division.

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Research finds the values measured with dynamic contrast enhanced computer tomography strongly correlated with fluorescence intensity measured directly from the pancreatic tissue.

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Utilizing a novel transgenic mouse model, Edward Usherwood, PhD of Dartmouth's Norris Cotton Cancer Center and collaborators found that CD4 T cells divide into two different populations that each has a different job.

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Elissa Ozanne, PhD from Dartmouth's Norris Cotton Cancer Center and colleagues concluded that mobile health devices are acceptable to older, diverse, and low income women.

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While doctors almost always agree on a pathological diagnosis of invasive breast cancer, there is room for improvement when diagnosing atypia (or atypical ductal hyperplasia-ADH) and DCIS (ductal carcinoma in-situ).

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The benefits of these findings are directly applicable to other reproductive challenges including gynecological cancers such as cervical cancer.

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Fast food ads aimed at kids fail to de-emphasize toy premiums, and fail to emphasize healthy menu items, investigators at Dartmouth-Hitchcock's Norris Cotton Cancer Center have found.

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Such findings have raised questions about the additional value of U.S. cancer care derived from the additional spending, in comparison to the situation in other high-income countries.

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The complex parts of the blue light known as the Cherenkov Effect can be measured and used in dosimetry to make therapies safer and more effective.

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Study determines if follicle stimulating hormone and estrogen at the upper limits of normal could predict treatment success as measured in live birth rates.

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While methods for identifying immunogenic hotspots, or epitopes, are evolving rapidly, technologies to redesign the hotspots while maintaining biotherapeutic activity and stability are far less developed.

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Coining the term "Gene Rank" (GR), Eugene Demidenko, PhD, captured a new characterization of gene connectivity by using a computer algorithm to compare tissues across or within organisms at great speed with a simple laptop computer.

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Sorting out patients with systemic sclerosis (SSc) according to their shared biology, researchers discovered how disease heterogeneity can be defined, allowing for targeted selection of patients for clinical trials.

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A collaborative national clinical trials group discovered that radiation therapy in addition to chemotherapy was even more effective at preventing recurrence of ductal carcinoma in situ (DCIS) than previously thought.

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In a study of 10 large health systems, researchers at Dartmouth and the University of Michigan found that implementation of pilot accountable care organizations (ACOs) did not limit spending on discretionary or non-discretionary cardiovascular treatment for patients.

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Dartmouth investigators note the lack of hypothesized scientific models for the mechanisms of action responsible for outcomes in Somatic Experiencing(SE) trauma therapy and other body-mind therapies.

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A novel Electron Paramagnetic Resonance (EPR) oximetry technique will help clinicians directly measure oxygen and schedule treatments at times of high oxygen levels in cancer and stroke patients to improve outcomes, The EPR team at Dartmouth's Geisel School of Medicine has found.

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Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, researchers at Norris Cotton Cancer Center and the Geisel School of Medicine at Dartmouth have found.

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Three papers in the survival monograph published by the Journal of the National Cancer Institute, co-authored by Dartmouth's Norris Cotton Cancer Center investigators Steven Woloshin, MD, MS, and Lisa Schwartz, MD, MS, aim to help doctors, patients, and policymakers better understand cancer prognosis and survival.

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In the search for new approaches to treat ERBB2 positive breast cancers that have become drug-resistant, Dartmouth investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism.

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By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform.