Scientists at the UNC School of Medicine have made a significant advance in the promising field of cellular reprogramming and organ regeneration, and the discovery could play a major role in future medicines to heal damaged hearts.
Led By Sam McLean, MD, MPH, director of the UNC Institute for Trauma Recovery, researchers have established an $8-million initiative funded through the U.S. Department of Defense to overcome this lack of understanding.
Published in Nature, this research in animal models show it’s possible to create a compound that hits the same exact target as psychedelic drugs hit – the 5-HT2A serotonin receptors on the surface of specific neurons – but does not cause the same psychedelic effects when given to mice.
UNC School of Medicine’s Donald Pathman, MD, MPH, found that most healthcare providers experienced either mild or intense levels of moral distress during the first year of the pandemic due to issues related to patient care and their workplaces.
UNC School of Medicine scientists discovered that a molecule called EdU, which is commonly used in laboratory experiments to label DNA, is in fact recognized by human cells as DNA damage, triggering a runaway process of DNA repair that is eventually fatal to affected cells, including cancer cells.
Scientists at the UNC School of Medicine have mapped the surface of the cortex of the young human brain with unprecedented resolution, revealing the development of key functional regions from two months before birth to two years after.
Research in animal models showed the potential of delivering a TB drug with one injection that lasts at least four months, in lieu of the current standard treatment requiring constant adherence to a daily drug regimen.
UNC School of Medicine researchers report that common genetic variations in one serotonin receptor could be a reason why people with psychiatric conditions, such as depression, respond differently to psychedelic treatments.
Results from the largest prospective study of its kind indicate that in the initial days and weeks after experiencing trauma, individuals facing potentially threatening situations who had less activity in their hippocampus developed more severe posttraumatic stress disorder (PTSD) symptoms.
UNC scientists conducted a study to image the neural activity analogues to cognitive flexibility and discover differences in the brain activity of children with ADHD and those without.
UNC School of Medicine researchers are beginning to parse the underlying genetic differences in people who abuse substances. The more they learn, the better chance they will be able to create therapies to help the millions of people who struggle with addiction.
Users of fourth-generation nicotine-salt-containing devices, such as Juul and disposable devices, display a unique mix of cellular biomarkers indicative of immune suppression.
UNC School of Medicine scientists discovered that hepatitis A viral replication requires specific interactions between a human protein and a group of enzymes, and they used a molecule to stop replication at this key interactive step, making it impossible for the virus to infect liver cells.
A study published in JAMA Pediatrics shows how frequently childcare insecurity during the COVID-19 pandemic occurred and the effect it had on parental job loss.
A case report published in the New England Journal of Medicine provides evidence that enterovirus D68 directly infects spinal cord neurons and that a corresponding robust immune response is present – a direct causation to the polio-like paralyzing illness, acute flaccid myelitis (AFM). Matthew Vogt, MD, PhD, assistant professor of pediatrics and microbiology & immunology at the UNC School of Medicine is the lead author of the study.
For the first time, scientists have found that brain differences in the visual brain systems of infants who later are diagnosed with autism are associated with inherited genetic factors.
Clinical scientists used machine learning models to explore de-identified electronic health record data in the National COVID Cohort Collaborative (N3C) to help discern characteristics of people with long COVID and factors that may help identify such patients using data from medical records.
During the COVID-19 pandemic, healthcare organizations, leaders, researchers, and practitioners have attempted on the fly to deal with the inherent stresses, strains, and struggles related to an unprecedented healthcare crisis in modern times.
UNC-Chapel Hill scientists boosted electrical activity between cells in the hypothalamus and the hippocampus to create new neurons – an important process called neurogenesis -- in animal models.
For the first time, UNC-Chapel Hill scientists have measured the concentration of a biomarker of the commonly used fungicide azoxystrobin in the urine of pregnant women and children. They also documented maternal transfer of the chemical to mouse embryos and weaning-age mice.
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