Researchers have known for decades that fevers in the first trimester of pregnancy increase risk for some heart defects and facial deformities such as cleft lip or palate. Exactly how this happens is unclear. Duke researchers now have evidence indicating that the fever itself, not its root source, is what interferes with the development of the heart and jaw during the first three to eight weeks of pregnancy.
An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer -- diffuse large B cell lymphoma – and how those genes might play a role in patients’ responses to therapies.
States that fully expanded their Medicaid programs under the Affordable Care Act cut their rates of uninsured cancer patients by more than half between 2011 and 2014. Black patients and those living in the highest poverty areas saw the greatest benefit from Medicaid expansion, according to a Duke Cancer Institute analysis.
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body’s own capacity to fight malignancies by activating an inflammation process that counter’s the ability of cancer cells to evade the immune system.
Researchers at Duke Cancer Institute have not only untangled an unusual wiring system that cancer cells use for carbohydrate metabolism, but also identified a natural compound that appears to selectively shut down this system in laboratory studies.
Compared to people who live in predominantly white neighborhoods, those who live in predominantly black areas are much less likely to receive CPR or defibrillation from a bystander when their heart suddenly stops beating while they are at home or out in the community.
In a large, international study led by the Duke Clinical Research Institute and five coordinating centers around the world, an informational campaign aimed at patients, families and physicians led to a 9-percent absolute increase in the use of anticoagulation therapies. The increased drug adherence was accompanied by a small, but notable reduction in the risk of stroke.
A third of insured people with cancer end up paying more out-of-pocket than they expected, despite having health coverage, researchers at the Duke Cancer Institute have found.
The push to develop treatments for Alzheimer’s disease has yielded a greater understanding of the disease, but has failed to generate successful new drugs. To blame are the many undefined subtypes of mild cognitive impairment, a precursor to Alzheimer’s disease. But if scientists grouped people with similar types of cognitive impairment, they could more precisely test the impact of investigational drugs, according to findings in a July 28 article in the journal Scientific Reports, a publication of Nature Research.
For the subset of women with BRCA mutations who have already had ovarian cancer, risk-reducing mastectomy might not be worth the price tag. New research from the Duke Cancer Institute finds that for many women in this unique group, prophylactic mastectomy does not produce a substantial survival gain versus breast cancer screening alone and is not cost-effective.
A team of hearing experts at Duke University School of Medicine and the Duke Global Health Institute is calling for a comprehensive, worldwide initiative to combat hearing loss.
Researchers from Duke University School of Medicine and Tulane National Primate Research Center report findings in monkeys that demonstrates a CMV vaccine approach that appears to be capable of protecting the animal’s fetus from infection.
Adding an investigational antibody to the chemotherapy rituximab appears to restore its cancer-killing properties in certain leukemia patients with a natural resistance to the drug, according to a small, proof-of-concept study by Duke Cancer Institute researchers.
Duke University researchers have identified a potential new mechanism for Parkinson's disease in both mice and human endocrine cells that populate the small intestines.
Building on insights from an HIV vaccine regimen in humans that had partial success during a phase 3 clinical trial in Thailand, a Duke-led research team used a more-is-better approach in monkeys that appeared to improve vaccine protection from an HIV-like virus.
A phase one study of 11 patients with glioblastoma who received injections of an investigational vaccine therapy and an approved chemotherapy showed the combination to be well tolerated while also resulting in unexpectedly significant survival increases, researchers at the Duke Cancer Institute report.
The MURDOCK Study, Duke Clinical Research Institute and Boehringer Ingelheim Pharmaceuticals Inc. announced today the launch of a new collaborative research effort to closely follow 850 people living with chronic obstructive pulmonary disease (COPD).
The chemical bisphenol A, or BPA, appears to aid the survival of inflammatory breast cancer cells, revealing a potential mechanism for how the disease grows, according to a study led by researchers in the Department of Surgery at Duke University School of Medicine and the Duke Cancer Institute.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right