Scientists at St. Jude Children’s Research Hospital found that, with early screening, they could detect new cancers in pediatric patients with an underlying genetic predisposition at their most treatable stages.
Learn about immunology research from the St. Jude laboratory of Thirumala-Devi Kanneganti, PhD, that revealed the function of the NLRC5 innate immune sensor.
St. Jude Children’s Research Hospital scientists address decades-long problem in the field of single-molecule fluorescence resonance energy transfer, paving the way for more accurate experiments.
See how St. Jude researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old.
Scientists at St. Jude Children’s Research Hospital designed an intersectional technique for precisely targeting subpopulations of cells and parsing out specific functions.
Scientists at St. Jude Children’s Research Hospital reveal the role of iRhom2’s defunct protein-cleaving domain in lifecycle of ADAM17, a key signaling molecule-activating protein.
Scientists at St. Jude Children’s Research Hospital uncovered a route to blocking activity of protein notorious for eliminating drugs, offering a potential boon to cancer therapy.
Hongbo Chi, PhD, a faculty member and the Robert G. Webster Endowed Chair in Immunology at St. Jude Children’s Research Hospital, has been recognized as a fellow of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society and publisher of the Science Family of Journals.
Explore how research targeting EP300/CBP protein in Group 3 medulloblastoma may advance targeted pediatric brain tumor treatments by inhibiting bromodomains.
Learn how ancestry changes genetic risk variants’ impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk.
Poor metabolic health or dysfunction, not obesity, leads to poor anti-influenza immune responses. Learn about the new St. Jude influenza vaccination research.
Smith is a nationally recognized academic radiologist with expertise in body and oncologic imaging, clinical trials and imaging research and the application of artificial intelligence (AI) in imaging and medicine.
Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.
St. Jude Children’s Research Hospital today announces the survivorship portal, part of the St. Jude Cloud ecosystem, for unparalleled data analysis and visualization.
Recent work by St. Jude Children’s Research Hospital scientists discovered which tumor cells resist treatment and why. By characterizing B-cells’ developmental stages, they designed and tested a drug combination to effectively treat resistant B-cell leukemia.
St. Jude Children’s Research Hospital scientists studying bilateral Wilms tumor found that chemotherapy resistance correlates with tumors favorable to surgery, reducing the need for additional therapy.
St. Jude Children’s Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state.
Scientists at St. Jude Children’s Research Hospital and Dana-Farber Cancer Institute found a small set of proteins that maintain anaplastic large cell lymphoma (ALCL) identity, representing potential future therapeutic targets.
Scientists at St. Jude Children’s Research Hospital showed that the MYCN protein promotes a switch in the cellular state within the tumor microenvironment, with slow-growing mesenchymal cells swapping to the more dangerous and faster-growing adrenergic state.
Researchers from St. Jude Children’s Research Hospital and The University of Tennessee Health Sciences Center discovered two T-cell receptors in a single patient that recognizes the fusion and can guide T cells to kill all tumor cells carrying the hybrid protein in a mouse model.
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