Burnham Institute for Medical Research will receive $ 5,925,878 in grants awarded from the California Institute for Regenerative Medicine as part of the first research grants approved under Proposition 71. The Independent Citizen's Oversight Committee approved the allocation of $45 million to fund 72 grants awarded under CIRM's Scientific Excellence through Exploration and Development Grant Program.
Researchers have developed nanoparticles that seek out tumors and bind to their blood vessels, and then attract more nanoparticles to the tumor target. Using this system they demonstrated that the homing nanoparticle could be used to deliver a "payload" of an imaging compound, and in the process act as a clotting agent, obstructing as much as 20% of the tumor blood vessels.
The Burnham Institute for Medical Research ("Burnham") has established an affiliation with the University of California, Santa Barbara led by internationally-renowned medical researcher Erkki Ruoslahti, M.D., Ph.D, the campus and the Institute announced today.
Muscle weakness and fiber deterioration seen in muscular dystrophy can be countered by a class of drugs currently under study for their effects against cancer, a Burnham Institute study has found. Deacetylase inhibitor Trichostatin A restored skeletal muscle mass and prevented the impaired function characteristic of muscular dystrophies.
Metabolic syndrome, an aging-associated group of disorders that includes insulin resistance, heart disease and high lipid levels, may be treatable thanks to a newly discovered role for a regulatory gene, according to a team of scientists at the Burnham Institute for Medical Research.
This data provides the first molecular link between NO free radicals and protein misfolding, which is currently thought to be a common pathway in the pathogenesis of virtually all neurodegenerative conditions. Such conditions also include ALS (or Lou Gehrig's disease), Huntington's disease, and many others.
Researchers have shown that endocrine progenitor stem cells exist in the adult human pancreas, and they have demonstrated that these stem cells can be transformed into insulin-producing cells.
Researchers have provided detailed insights into the early formation of the heart. A team found that two proteins, called Robo and Slit, are required for normal development of the heart and that malfunction of either of these proteins severely impacts the heart's structure, resulting in congenital heart defects.
A collaboration has found that an antibody which binds to an unusual sugar molecule residing in the gut halts the inflammation seen in Crohn's disease and other intestinal inflammations. The antibody could prove to be a promising drug target for these common chronic intestinal disorders.
A study reports that a cell-cycle checkpoint protein, known to be activated by an important class of anticancer drugs, may play crucial roles in both the hampering of therapeutic actions and aiding cancer cells to "recover" and start dividing again after treatment with these drugs.
The National Foundation for Cancer Research has aligned with The Prostate Cancer Foundation to grant $200,000 in seed funding to The Burnham Institute's NCI-designated Cancer Center to develop three-dimensional experimental culture systems that simulate a tumor's micro-environment.
The Burnham Institute will receive $3 M over the next three years from the NIH to develop an "Exploratory Center for Human Embryonic Stem Cell Research". The grant provides funds to support research that will advance understanding of the fundamental biology of human embryonic stem cells.
A research team lead by the Burnham Institute has synthesized and tested a new series of inhibitors that can prevent the type of nerve cell injury and death associated with many neurodegenerative diseases and stroke.
A collaborative team of scientists has identified inhibitors of the anthrax toxin, termed lethal factor that could be developed into an emergency treatment for exposure to inhalation anthrax.
The Burnham Institute has been selected as a "Program of Excellence in Nanotechnology" by the National Heart, Lung, and Blood Institute of the National Institutes of Health.
A Burnham Institute study has found that a protein known for its role in gene regulation has another important function, that of initiating DNA repair. The study points to new targets for treatment of cancer.
A Burnham Institute study has found that one of the cell's largest families of signaling molecules, called ephrins, which are known to regulate the development of nerve cells, also controls nerve cells' ability to engulf critical chemicals and proteins for learning and memory.
A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes.
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