The yearly influenza vaccine that health officials urge people to get each fall might also offer certain individuals some cross protection against the H5N1 virus, commonly known as bird flu, according to investigators at St. Jude Children's Research Hospital.
The degeneration of brain cells that occurs in Parkinson's disease may be caused by either externally provoked cell death or internally initiated suicide when the molecule that normally prevents these fatal alternatives is missing, according to studies in mouse models by investigators at St. Jude.
The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself"”a disorderly molecule that seems to have a mind of its own, say investigators at St. Jude, Innsbruck Medical University and Max Planck Institute.
The complex task of launching a well-organized, effective immune system attack on specific targets is thrown into high gear when either of two specific enzymes chop a protein called LAG-3 off the immune cells leading that battle, according to investigators at St. Jude Children's Research Hospital.
Brain tumors appear to arise from cancer stem cells that live within microscopic protective "niches" formed by blood vessels in the brain; and disrupting these niches is a promising strategy for eliminating the tumors and preventing them from re-growing, according to investigators at St. Jude.
The freeze-frame image of a molecular relay race, in which one enzyme passes off a protein like a baton to another enzyme, has solved a key mystery to how cells control some vital functions, according to investigators at St. Jude Children's Research Hospital.
The establishment of research ethics committees in El Salvador will enhance the ability of that country to undertake clinical trials aimed at improving cure rates of pediatric catastrophic diseases, according to St. Jude Children's Research Hospital.
Mice with neuroblastoma tumors have been successfully treated with genetically modified cells that sought out the cancer cells and activated a chemo drug directly at those sites, according St. Jude and their colleagues at City of Hope National Medical Center and the University of British Columbia.
Investigators at St. Jude Children's Research Hospital have demonstrated in mice a way that might reduce the time it takes for a bone marrow transplant to rebuild a child's immune system, and so reduce the risk of potentially fatal virus infections that can occur during this time.
A troublesome side effect caused by some cancer drugs appears to be caused by a broken "pump" in the liver that fails to push these medicines into a "drain," according to investigators at St. Jude Children's Research Hospital.
Magnetic resonance imaging (MRI) could become a valuable tool for predicting the risk of muscle injury during and following radiation therapy, according to investigators at St. Jude Children's Research Hospital.
Scientists at St. Jude Children's Research Hospital have demonstrated in a mouse model a new, locally applied treatment for the eye cancer retinoblastoma that not only greatly reduces the size of the tumor, but does so without causing the side effects common with standard chemotherapy.
A new variant of the bird flu virus H5N1 emerged in late 2005 and replaced most of the previous variants across a large part of southern China, despite an ongoing program to vaccinate poultry, according to researchers at the University of Hong Kong in collaboration with scientists at St. Jude Children's Research Hospital.
Investigators at St. Jude Children's Research Hospital have discovered in mouse models that a gene called Six3 is one of the earliest critical regulators controlling lens development in the eye of the mammalian embryo.
Investigators at St. Jude Children's Research Hospital have discovered in mouse models how cell walls from certain pneumonia-causing bacteria can cause fatal heart damage; researchers have also shown how antibiotic therapy can contribute to this damage by increasing the number of cell wall pieces shed by dying bacteria.
Clinicians at St. Jude Children's Research Hospital have successfully demonstrated an improved technique for blood stem cell transplantations in children that shows promise for those most likely to fail standard treatment for leukemia.
A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital.
Investigators at St. Jude Children's Research Hospital turned up the heat on "disorderly" proteins and confirmed that most of these unruly molecules perform critical functions in the cell.
Investigators at St. Jude Children's Research Hospital have discovered that a protein called ABCB6 plays a central role in production of a molecule that is key to the ability of red blood cells to carry oxygen, of liver cells to break down toxins, and of cells to extract energy from nutrients.
Children with cancer who suffer hearing loss due to the toxic effects of chemotherapy might one day be able to get their hearing back through pharmacological and gene therapy, thanks to work done with mouse models at St. Jude Children's Research Hospital.
A team of investigators led by St. Jude Children's Research Hospital has announced that improvements in the treatment of the childhood brain cancer medulloblastoma have significantly increased the rate of survival of children with this disease.
Statisticians at St. Jude Children's Research Hospital have developed a new technique that allows researchers to statistically analyze results of clinical trials.
A 25-year quest to identify the first biochemical step that many disease-causing bacteria use to build their membranes has led to a discovery that holds promise for effective, new antibiotics against these bacteria, according to investigators at St. Jude Children's Research Hospital.
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St. Jude Children's Research Hospital took on the fight against sickle cell disease very early in its history. Today, the St. Jude Comprehensive Sickle Cell Center is one of the largest such programs in the United States; and it is one of only 10 Comprehensive Sickle Cell Centers funded by the National Heart, Lung and Blood Institute.
Scientists at St. Jude Children's Research Hospital have demonstrated that a key event during apoptosis (cell suicide) occurs as a single, quick event, rather than as a step-by-step process. Apoptosis eliminates extraneous cells from the developing body; and disposes of cells that sustain irreparable harm to their DNA or are infected with microorganisms.
Scientists at St. Jude Children's Research Hospital have developed a mouse model of a severe disease of the immune system that helps explain why gene therapy used to treat children with this disease at an institution in Europe caused some of them to develop leukemia.
Children with cancer who develop anemia during chemotherapy can benefit from a weekly dose of erythropoietin (EPO), according to researchers at St. Jude Children's Research Hospital. The drug reduces the need for red blood cell transfusions and improves quality of life in children whose anemia is corrected by this treatment, according to results of a Phase III clinical trial at St. Jude.
A gene critical for normal mammary gland function during nursing helps trigger highly lethal leukemias when it undergoes a mutation that fuses it to another gene, according to investigators at St. Jude Children's Research Hospital.
Investigators at St. Jude Children's Research Hospital have discovered that the cells of the developing nervous system of the mammalian embryo have an exquisite sense of timing when it comes to fixing broken chromosomes: the cells use one type of repair mechanism during the first half of development and another during the second half.
Scientists at St. Jude Children's Research Hospital have announced that a vaccine they developed a few years ago against one antigenic variant of the avian influenza virus H5N1 may protect humans against future variants of the virus.
St. Jude Children's Research Hospital has significantly reduced the rate at which families in Recife, Brazil abandon treatment for their children who have acute lymphoblastic leukemia (ALL), and has significantly increased the rate of event-free survival during a single decade.
Investigators at St. Jude Children's Research Hospital have discovered the role of several key genes in the development of the retina, and in the process have taken a significant step toward understanding how to prevent or cure the potentially deadly eye cancer retinoblastoma.
The emergence of the avian influenza virus H5N1 that is currently devastating chicken flocks in many countries and threatening to unleash a worldwide epidemic among humans has triggered a renewed interest among scientists in studying influenza A viruses, according to investigators at St. Jude Children's Research Hospital.
A commercially developed vaccine has successfully protected mice and ferrets against a highly lethal avian influenza virus, according to the investigator who led the study at St. Jude Children's Research Hospital. The vaccine was developed by Vical Incorporated in San Diego, California.
Investigators at St. Jude Children's Research Hospital have used mouse models to determine why some forms of acute lymphoblastic leukemia (ALL) are extremely aggressive and resist a drug that is effective in treating a different type of leukemia.
Investigators at St. Jude Children's Research Hospital have developed a strategy to speed future development of more effective and less toxic treatments for medulloblastoma, a type of brain cancer.
Investigators have developed a relatively simple and inexpensive test that identifies children with acute lymphoblastic leukemia (ALL) who have responded well enough to their first round of chemotherapy that they might be successfully treated with a much less aggressive follow-up treatment.
Scientists have given investigators around the world free access to a powerful tool for studying brain development. The Internet-based tool, called the mouse Brain Gene Expression Map (BGEM), is one of the largest gene expression maps of an organ ever developed.
Robert G. Webster, Ph.D., who holds the Rose Marie Thomas Chair at St. Jude Children's Research Hospital, has been given the Distinguished Biotechnologist of the Year Award by the New Zealand Biotechnology Association (NZBio) for his work in virology and avian influenza.
Investigators have completed the first large-scale study of bird flu virus genomes, thereby doubling the amount of genetic information available on the genes and proteins of these viruses. The results of the project could lead to major insights into the bird flu virus known as H5N1, the researchers said.
Individuals who have a rare genetic immune system disorder that prevents them from making antibodies nevertheless appear to be moderately healthy and lead productive lives, according to results of a study by investigators at St. Jude Children's Research Hospital.
The cure rate for the once almost universally fatal childhood cancer acute lymphoblastic leukemia could reach 90 percent in the near future, thanks to improvements in diagnosis and treatment over the past four decades, according to investigators.
The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively metastasizing, according to investigators.
A new strategy that turns small populations of immune system cells into armies that track down and kill neuroblastoma throughout the body could save the lives of many children each year, according to investigators at St. Jude Children's Research Hospital.
A new strategy for treating childhood acute myeloid leukemia based on the individual patient's risk of failure, and guided by the results of a highly sensitive technique for identifying leukemic cells, yielded one-year survival rates of almost 90 percent, according to investigators.
A protein called TRAF3 with a previously unknown job in immune cells, is a key part of a mechanism that triggers release of anti-virus molecules as part of the body's rapid response against these invaders, according to investigators.
Adults who abuse cocaine might increase their risk of developing Parkinson's disease, and pregnant women who abuse cocaine could increase the risk of their children developing PD later in life, according to results of laboratory studies.
A protein called Scythe determines which cells live and which die during the growth and development of the mammalian embryo, according to investigators at St. Jude Children's Research Hospital.
The disruption of a molecular bridge that holds together the molecule p53 tends to destabilize this protein, allowing it to form potentially disease-causing aggregates, or "clumps," according to a study by investigators at St. Jude Children's Research Hospital.
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