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Maternal mortality in the United States in on the rise. Scientists increasingly recognize that pregnancy-associated deaths — those due to conditions unrelated to the physiologic effects of pregnancy — are important and potentially preventable contributors to maternal mortality. Maternal deaths due to homicide and suicide are thought to represent a significant number of pregnancy-associated deaths, but have been under explored as an area of potential intervention.

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Beth Israel Deaconess Medical Center (BIDMC) and Deerfield Management, a healthcare investment firm, announce a research collaboration to accelerate discovery of novel therapeutics. Deerfield will provide up to $130 million along with additional scientific and operational support to this collaboration to advance BIDMC research that has the potential to transform patient care over the next decade.

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In a paper published in JAMA Network Open, physician-scientists assessed the use of these two monoclonal antibodies for patients with COVID-19 before and after FDA deauthorization.

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Physician-scientists assessed whether lipid concentrations and rates of lipid control changed among U.S. adults from 2007 to 2018. The researchers observed that while mean cholesterol concentrations improved among U.S. adults overall during this time period, there were concerning variations in these trends by race and ethnicity.

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Lahey Hospital & Medical Center and UMass Chan Medical School have signed a Letter of Intent to explore establishing a regional medical campus that would help train, develop and support the next generation of healthcare leaders.

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Researchers have identified a key enzyme which catalyzes the degradation of a potent activator of beige fat biogenesis.

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In a paper published in JAMA Network Open, physician-scientists assessed how pregnancy-related complications and obstetric outcomes changed during the COVID-19 pandemic compared to pre-pandemic.

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Researchers report that exposure to cold temperatures resolved obesity-induced inflammation while improving insulin sensitivity and glucose tolerance in diet-induced obese mice.

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Researchers conducted a systematic assessment of more than 200,000 scientific publications to understand the breadth and diversity of biological pathways that contribute to Alzheimer’s disease by research over the last 30 years.

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In a letter published in the New England Journal of Medicine, physician-scientists report that the three Omicron subvariants currently dominant in the United States – officially known as subvariants BA.2.12.1, BA.4, and BA.5 – substantially escape neutralizing antibodies induced by both vaccination and previous infection.

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Endocrinologists have identified a key enzyme in the synthesis of a new class of lipids (or fats), called FAHFAs, that are made in human tissues and have beneficial effects on insulin sensitivity, blood sugar control and other metabolic-related parameters in humans and mice. The discovery, published in Nature, opens the door to potential new treatments for Types 1 and 2 diabetes.

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While earlier guidelines had restricted screening to only those individuals with BRCA 1/2 who had a family history of pancreatic cancer, the new guidelines expand indication for screening for all with the gene variations regardless of family history.

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Researchers sought to reduce racial and ethnic disparities in diabetes diagnosis.

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In a recent study, scientists at the Harvard T.H. Chan School of Public Health and Beth Israel Deaconess Medical Center used live virus culture to assess how well four rapid antigen tests are able to detect these COVID variants of concern.