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Former Chair of Computational Biology honored with induction into Class of 2023 Fellows.

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Scientists at St. Jude Children’s Research Hospital used genomics to inform the creation of genetic and new cell-line models for hepatoblastoma, which pointed toward the DNA damage repair pathway as a promising therapeutic route.

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Scientists at St. Jude Children’s Research Hospital and colleagues in Latin America found that early identification of clinical deterioration saves lives, especially in hospitals with the greatest need.

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Scientists at St. Jude Children’s Research Hospital found that altering amounts of the nutrient glutamine in the tumor microenvironment could enhance or impair the immune system’s anti-cancer response.

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Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease and beta thalassemia. Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment.

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Scientists at St. Jude Children’s Research Hospital found key “on” switch, NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.

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Scientists at St. Jude Children’s Research Hospital have discovered H5N1 avian influenza viruses gained the ability to cause severe disease and target the brain in mammals as they spread across North America.

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Scientists at St. Jude Children’s Research Hospital studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA.

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Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.

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Scientists report six structures of the Spns2 transporter, which is linked to cancer and other diseases, including while it is bound to a small molecule inhibitor, thus aiding future therapeutic design.

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The Director of the Center of Excellence for Data-Driven Discovery at St. Jude Children’s Research Hospital was named a Fellow of the leading, 360-year-old British scientific organization. The Royal Society is the oldest scientific academy in continuous existence.

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An upgraded computational tool from St. Jude Children’s Research Hospital can find potentially druggable hidden drivers of cancer and other biological processes using multi-omics data.

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Scientists from St. Jude Children’s Research Hospital investigated neighborhood-level economic hardship and its effect on cognitive outcomes in children treated with radiation for brain tumors. The results imply that policies and resources providing support at a neighborhood level may help protect high-risk pediatric brain tumor patients from cognitive decline.

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Investigators from St. Jude Children’s Research Hospital found that proton therapy had efficacy similar to conventional photon therapy with fewer negative neurocognitive outcomes. The clinical trial may set the new "gold standard" for pediatric craniopharyngioma treatment.

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Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.

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The American Association of Cancer Research (AACR) will honor two investigators from St. Jude Children’s Research Hospital for their research contributions. Melissa Hudson, M.D., director of the Cancer Survivorship Division and Jun J. Yang, Ph.D., vice-chair of Pharmacy and Pharmaceutical Sciences

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St. Jude Children’s Research Hospital scientists developed a combination therapy for a leukemia subtype harboring rearrangements in the KMT2A gene. The approach overcomes the cancer’s drug resistance, without adding toxicity. The study appears in Proceedings of the National Academy of Science.

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St. Jude Children’s Research Hospital researchers found childhood cancer survivors have higher mortality than the public, but survivors with a healthy lifestyle and fewer heart disease risk factors had lower risk.

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Scientists at St. Jude Children’s Research Hospital comprehensively characterized oncogenic fusions in pediatric cancer, providing proof-of-principle for genetic engineering-based therapies.

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Scientists at St. Jude Children’s Research Hospital have found that human ribosomes decode mRNA slower than bacteria, with implications for drug development.