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10-Sep-2018 2:00 PM EDT
Timing May Be Everything When Taking Meds
Cincinnati Children's Hospital Medical Center

Using new bioinformatics tools to analyze thousands of human tissue samples, researchers created a new database of daily rhythms in human gene activity—including many genes that regulate how drugs work. Reporting in Science Translational Medicine, scientists say their results could have significant implications for a growing field of study called circadian medicine.

Released: 10-Sep-2018 11:45 AM EDT
Scientists Block RNA Silencing Protein in Liver to Prevent Obesity and Diabetes in Mice
Cincinnati Children's Hospital Medical Center

Obesity and its related ailments like type 2 diabetes and fatty liver disease pose a major global health burden, but researchers report in Nature Communications that blocking an RNA-silencing protein in the livers of mice keeps the animals from getting fat and diabetic conditions.

Released: 23-Aug-2018 12:30 AM EDT
Scientists Close in on Mystery Surrounding Dangerous Blood Syndromes
Cincinnati Children's Hospital Medical Center

Scientists may be on the road to solving the mystery of a group of mostly incurable blood diseases called myelodysplastic syndromes (MDS), which cause people to have immature, malfunctioning bone marrow cells that fuel a diverse set of health problems and can lead to leukemia. Researchers report in the journal Cancer Discovery identifying a gene that in laboratory experiments fuels the biological processes that cause the different types of MDS that physicians see in patients.

Released: 7-Aug-2018 1:45 PM EDT
Taking a Pill Can Effectively Treat Brutal Lung Disease
Cincinnati Children's Hospital Medical Center

Researchers report in Nature Communications they figured out why air sacs in the lungs clog up with a thick substance called surfactant in a brutal disease called Pulmonary Alveolar Proteinosis (PAP), and they show taking cholesterol-busting pills called statins can effectively treat the disease.

14-Jun-2018 11:05 AM EDT
Study Suggests Well-Known Growth Suppressor Actually Fuels Lethal Brain Cancers
Cincinnati Children's Hospital Medical Center

Scientists report finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma. Publishing online June 18 in Nature Cell Biology, the study also reports the current lack of a drug that hits the molecular target keeps it from being advanced for testing as a therapeutic strategy for patients with few treatment options.

13-Jun-2018 2:45 PM EDT
Scientists Learn More about How Gene Linked to Autism Affects Brain
Cincinnati Children's Hospital Medical Center

New preclinical research shows a gene already linked to a subset of people with autism spectrum disorder is critical to healthy neuronal connections in the developing brain, and its loss can harm those connections to help fuel the complex developmental condition. Scientists report in Developmental Cell their data clarify the biological role of the gene CHD8 and its protein CHD8 in developing oligodendrocytes, cells that form a protective insulation around nerves.

21-May-2018 3:00 PM EDT
Helping Preterm Infants Grow Bigger Kidneys Would Prevent Kidney Disease Later in Life
Cincinnati Children's Hospital Medical Center

A study led by scientists at Cincinnati Children’s reveals one mechanism involved in regulating when nephron formation ends. If translated to clinical practice years from now, the result could be reduced need for kidney transplants and fewer deaths from kidney disease.

10-May-2018 8:30 AM EDT
Taming Random Gene Changes As Our Bodies Start to Form
Cincinnati Children's Hospital Medical Center

Scientists exploring how to tame random gene fluctuations as the embryos that become our bodies start to form have identified a control switch in the vertebrate segmentation clock of developing zebrafish. The researchers report in Cell Reports their findings could uncover methods for modulating genetic signals to prevent birth defects or cancers rooted at the earliest stages of development.

   
2-May-2018 11:30 AM EDT
Tissue Engineered Human Pancreas Cells Successfully Treat Diabetic Mice
Cincinnati Children's Hospital Medical Center

Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice. In a study published by Cell Reports, the scientists use a new bioengineering process they developed called a self-condensation cell culture. The technology helps nudge medical science closer to one day growing human organ tissues from a person’s own cells for regenerative therapy

30-Apr-2018 11:50 AM EDT
Liver Fix Thyself
Cincinnati Children's Hospital Medical Center

By studying a rare liver disease called Alagille syndrome, scientists discovered the mechanism behind a form of tissue regeneration that may someday reduce the need for organ transplants. Researchers report in Nature that when disease or injury causes a shortage in one type of liver cell, the organ can instruct another type of liver cell to change identities to provide replacement supplies. The findings one day may lead to a viable treatment for human disease.

25-Apr-2018 1:00 PM EDT
Scientists Map Key Brain-to-Spinal Cord Nerve Connections for Voluntary Movement
Cincinnati Children's Hospital Medical Center

Researchers mapped critical brain-to-spinal cord nerve connections that drive voluntary movement in forelimbs, a development that scientists say allows them to start looking for specific repair strategies. The study is an important step toward one day rehabilitating motor circuits to help motor function recover after an injury or disease damages the central nervous system, the scientists report in Cell Reports.

Released: 17-Apr-2018 10:05 AM EDT
Study Reports Possible Novel Method for Stopping Untreatable Pediatric Brain Cancer
Cincinnati Children's Hospital Medical Center

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. Scientists report in the journal Molecular Cancer Therapeutics testing the small molecule 6-thio-2’deoxyguanosine (6-thio-dG) in brain cancer stem cells derived from tumor cells donated by patients. Researchers also tested the treatment in humanized mouse models of pediatric brain cancer.

12-Apr-2018 12:00 PM EDT
‘Mono’ Virus Linked to Seven Serious Diseases
Cincinnati Children's Hospital Medical Center

A study by scientists at Cincinnati Children’s reports that the Epstein-Barr virus (EBV)—best known for causing mononucleosis—also increases the risks for some people of developing seven other major diseases. Published in Nature Genetics, researchers report EBV also plays a role in six other diseases: multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis, and celiac disease.

Released: 13-Apr-2018 10:05 AM EDT
Blocking Matrix-Forming Protein Might Prevent Heart Failure
Cincinnati Children's Hospital Medical Center

Scientists used an experimental targeted molecular therapy to block a matrix-forming protein in heart cells damaged by heart attack, reducing levels of scarred muscle tissue and saving mouse models from heart failure. Researchers at the Cincinnati Children’s Heart Institute report in the journal Circulation

9-Apr-2018 1:30 PM EDT
Study Identifies New Molecular Target for Treating Deadly Lung Disease IPF
Cincinnati Children's Hospital Medical Center

Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclinical laboratory tests. Researchers at Cincinnati Children’s Hospital Medical Center report their data in the journal Cell Reports. Studying mice with IPF and donated human cells, they identified a gene called FOXF1 that inhibits the IPF disease.

Released: 23-Mar-2018 10:05 AM EDT
Fetal Surgery Brings Hope
Cincinnati Children's Hospital Medical Center

A few months into her pregnancy, Anisah Brown had a routine ultrasound that detected a large hole in her baby’s diaphragm. Her baby had been diagnosed with a congenital diaphragmatic hernia, or CDH. The hole would let the liver, stomach and other internal organs compress the lungs, leaving them little room to develop. Her doctor told her there was no hope. But that was before she came to the Cincinnati Fetal Center.

Released: 21-Mar-2018 12:45 PM EDT
Early Life Adversity for Parents Linked to Delayed Development of Their Children
Cincinnati Children's Hospital Medical Center

Researchers at Cincinnati Children’s report in the journal Pediatrics a link between parents impacted by adverse childhood experiences and increased risk for delayed development of their children at age two.

Released: 19-Mar-2018 10:05 AM EDT
Protecting Young Children from Opioid Overdoses
Cincinnati Children's Hospital Medical Center

The Cincinnati Drug and Poison Information Center at Cincinnati Children's is seeing an increasing number of calls regarding drug overdoses as the nation copes with the opioid epidemic.

Released: 13-Feb-2018 11:30 AM EST
Understanding a Fly’s Body Temperature May Help People Sleep Better
Cincinnati Children's Hospital Medical Center

In findings that one day may help people sleep better, scientists have uncovered the first molecular evidence that two anciently conserved proteins in the brains of insects and mammals share a common biological ancestry as regulators of body temperature rhythms crucial to metabolism and sleep. Researchers publish their data in the journal Genes & Development.

7-Feb-2018 1:15 PM EST
Study Suggests Way to Attack Deadly, Untreatable Nerve Tumors
Cincinnati Children's Hospital Medical Center

Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models, according to research in the journal Cancer Cell.



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