All cells have the ability to recycle unwanted or damaged proteins and reuse the building blocks as food. But cancer cells have ramped up the system, called autophagy, and rely on it to escape damage in the face of chemotherapy and other treatments. Now, researchers have developed a potent new drug that clogs up the recycling machinery and kills tumor cells in mouse models.
A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that mice in which an enzyme called histone deacetylase 3 (HDAC3) was deleted had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance, the hallmark of diabetes.
After nearly 13 years of study and intense debate, a pair of new papers from the Perelman School of Medicine, at the University of Pennsylvania have confirmed exactly how a once-popular class of anti-inflammatory drugs leads to cardiovascular risk for people taking it.
Two drugs commonly used to treat AMD yield similar improvements in vision for patients receiving treatments on a monthly or as-needed basis, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.
A regulator of glucocorticoid receptors may provide a path towards resilience to stress by modulating glucocorticoid signaling in the brain.
PPMC has achieved Magnet® status – the highest institutional honor awarded for nursing excellence – from the American Nurses Credentialing Center’s (ANCC) Magnet Recognition Program®. One of only 23 Magnet hospitals in Pennsylvania, PPMC’s achievement was granted unanimously by the ANCC’s Commission on Magnet. The status recognizes the quality of the hospital’s faculty and staff, and the dedication to reinforcing a culture of excellence.
Center for Neurodegenerative Disease Research researchers showed that brain tissue from a Parkinson's disease mouse model , as well as synthetically produced disease protein fibrils, injected into young, symptom-free mice led to spreading of a-syn pathology.
In work published in the Journal of Clinical Investigation researchers question the wisdom of blocking the DP1 receptor in patients prone to cardiovascular disease, especially those taking niacin.
More than 60 percent of breast cancer survivors report at least one treatment-related complication even six years after their diagnosis, according to a new study led by a researcher from the Perelman School of Medicine at the University of Pennsylvania. The findings are part of a special issue of Cancer devoted to exploring the physical late effects of breast cancer treatment and creating strategies to prevent, monitor for, and treat these conditions in the nation’s 2.6 million survivors of the disease.
A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend on inhibiting two protein complexes, mTORC1 and mTORC2, respectively. The study suggests that molecules that specifically inhibit mTORC1 may combat age-related diseases without the insulin-resistance side effect, which can predispose people to diabetes.
Patients with end-stage liver disease complicated by the most common type of liver cancer are less likely to die or become too sick for a transplant while waiting for a new liver than those with other complications of end-stage liver disease, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The investigators say their findings should prompt a re-examination of the criteria used to prioritize liver transplant candidates.
Intervention by peer mentors has a statistically significant effect on improving glucose control in African American veterans with diabetes, according to a study by researchers at the Perelman School of Medicine at the University of Pennsylvania and the Philadelphia VA Center for Health Equity Research and Promotion (CHERP). Full results of the study were published in the March 20th issue of the Annals of Internal Medicine.
The Hospital of the University of Pennsylvania (HUP) has been accredited for the second time as a Magnet® organization – the highest institutional honor granted for nursing excellence – from the American Nurses Credentialing Center’s (ANCC) Magnet Recognition Program®.
A study published this week in the Journal of Neuroscience shows that the compound epothilone D (EpoD) is effective in preventing further neurological damage and improving cognitive performance in a mouse model of Alzheimer's disease (AD). The results establish how the drug might be used in early-stage AD patients.
OncoLink®, a free cancer information website developed by experts at the University of Pennsylvania’s Abramson Cancer Center has launched a redesigned website based on the search habits and feedback from patients, caregivers and health care providers who use the site. Enhanced, interactive features provide access the most up-to-date information on cancers of all kinds, and allows users to develop personalized survivorship plans, and review the latest cancer research more easily.
Only about 75 percent of HIV/AIDS patients in the United States remain in care consistently, according to new research from the Perelman School of Medicine at the University of Pennsylvania published online this week in AIDS. The study of patients across the United States is the first to provide a comprehensive national estimate of HIV care retention and information about patients who are most likely to continue their treatment over time.
Aggressive treatment for severe traumatic brain injuries costs more than routine care, yet yields significantly better outcomes, improved quality of life, and lower long term care costs, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania.
In a Perspective piece published online this week in the journal Circulation: Cardiovascular Quality Outcomes, two University of Pennsylvania researchers outline the tremendous potential associated with greater utilization of AEDs in public places and a method to find the devices and help more people use them during emergencies.
Researchers at the Perelman School of Medicine at the University of Pennsylvania have put sleeplessness on the map - literally. The research team, analyzing nationwide data collected by the Centers for Disease Control and Prevention (CDC), has produced the first state-by-state sleep maps for the United States, revealing that residents of Southern states suffer from the most sleep disturbances and daytime fatigue, while residents on the West Coast report the least amount of problems.
Researchers at the Perelman School of Medicine at the University of Pennsylvania report that a short course of vaccination with an anti-HER2 dendritic cell vaccine made partly from the patient’s own cells triggers a complete tumor eradication in nearly 20 percent of women with ductal carcinoma in situ (DCIS), an early breast cancer.
People who suffer from sleep disturbances are at major risk for obesity, diabetes, and coronary artery disease, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Penn researchers have discovered that pancreatic cancer cells in an animal model begin to spread before clinically obvious tumor tissue is detected. What’s more, they showed that inflammation enhances cancer progression in part by facilitating a cellular transformation that leads to entry of cancer cells into the circulation.
Men are four times more likely to develop liver cancer compared to women, a difference attributed to the sex hormones androgen and estrogen. Although this gender difference has been known for a long time, the molecular mechanisms by which estrogens prevent -- and androgens promote -- liver cancer remain unclear. Now, new research at Penn, has found that the difference depends on which proteins the sex hormones bind next to.
Atrophy in the hippocampus, the region of the brain known for memory formation and storage, is evident in Parkinson’s disease (PD) patients with cognitive impairment, including early decline known as mild cognitive impairment (MCI), according to a study by researchers in the Perelman School of Medicine at the University of Pennsylvania. The study is published in the December issue of the Archives of Neurology, one of the JAMA/Archives journals.
group of Penn Medicine researchers is set to save lives with cell phone cameras -- and they're challenging the public to help. The MyHeartMap Challenge, a month-long contest slated to take place beginning in mid January, will send thousands of Philadelphians to the streets and to social media sites to locate and capture information about as many automated external defibrillators (AEDs) as they can. The contest is just a first step in what the Penn team hopes will grow to become a nationwide, crowd-sourced AED registry project that will put the lifesaving devices in the hands of anyone, anywhere, anytime.
Researchers from the Perelman School of Medicine at the University of Pennsylvania found a new way of diagnosing and tracking Alzheimer's disease, using an innovative magnetic resonance imaging (MRI) technique called Arterial spin labeling (ASL) to measure changes in brain function.
In two new studies presented at the 2011 American Heart Association Scientific Sessions, Penn researchers show that the systemic inflammatory impact of psoriasis may alter both the makeup of cholesterol particles and numbers, as well as impair the function of high density lipoprotein (HDL), the “good” cholesterol.
A team of researchers co-led by the University of Pennsylvania has developed and tested a new high-resolution, ultra-thin device capable of recording brain activity from the cortical surface without having to use penetrating electrodes.
Penn Medicine faculty will be involved in presenting research findings on the latest advances in cardiovascular medicine, science, and education at the 2011 American Heart Association Scientific Sessions, in Orlando, FL, November 12 – 16, 2011.
For the first time in the Delaware Valley Region, a patient has undergone a complex and intricate bilateral hand transplant that could significantly enhance the quality-of-life for persons with multiple limb loss.
For the first time in the Delaware Valley Region, a patient has undergone a complex and intricate transplant procedure that could significantly enhance the quality-of-life for persons with multiple limb loss.
A new study from researchers at the Perelman School of Medicine at the University of Pennsylvania suggests that cardiovascular disease may be an unfortunate consequence of mammalian evolution.
For the first time, researchers from the Perelman School of Medicine at the University of Pennsylvania have shown that a psychosocial treatment can significantly improve daily functioning and quality of life in the lowest-functioning cases of schizophrenia.
Despite what Hollywood would have you believe, not all epidemics involve people suffering from zombie-like symptoms--some can only be uncovered through door-to-door epidemiology and advanced mathematics. Michael Levy, PhD, assistant professor of Biostatistics and Epidemiology, and colleagues, are in the trenches combining tried-and-true epidemiological approaches with new statistical methods to learn more about the course of a dangerous, contagious disease epidemic.
Pulmonary arterial hypertension (PAH) patients of different sexes and races respond differently to treatment with commonly used medications for the disease, says a new study from researchers at Perelman School of Medicine at the University of Pennsylvania.
A new report from the Perelman School of Medicine at the University of Pennsylvania tackles the ethical and logistical challenges of safely and effectively communicating a diagnosis of pre-clinical Alzheimer's disease in light of the gulf between diagnosis and treatment.
Researchers from the Perelman School of Medicine at the University of Pennsylvania have been awarded another five-year, $3.2 million grant from the National Institutes of Health (NIH) to continue the programs of the Penn Center for Musculoskeletal Disorders. Penn is one of five institutions nationally with this Center award and the only one of the three up for renewal in the cycle to be re-funded.
A sideline visual test effectively detected concussions in collegiate athletes, according to a team of researchers from the Perelman School of Medicine at the University of Pennsylvania. This quick visual test, easily administered on the playing field, holds promise as a complement to other diagnostic tools for sports-related concussion.
A new study by researchers from the Perelman School of Medicine at the University of Pennsylvania shows that declines in hearing ability may accelerate gray mater atrophy in auditory areas of the brain and increase the listening effort necessary for older adults to successfully comprehend speech.
A three-pronged immunotherapy approach nearly doubles five-year survival among patients with rare leukemic form of cutaneous T-cell lymphoma, reports a new study by dermatologists from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania.
In a study just published in BMC Cancer, Perelman School of Medicine at the University of Pennsylvania researchers found that a diet of flaxseed given to mice not only protects lung tissues before exposure to radiation, but can also significantly reduce damage after exposure occurs.
Six simple clinical risk factors could help identify women most at risk.
Social media tools like Facebook, Twitter and Foursquare may be an important key to improving the public health system’s ability to prepare for, respond to, and recover from disasters, according to a New England Journal of Medicine “Perspective” article from the Perelman School of Medicine at the University of Pennsylvania to be published this week.
The Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania announces the launching of a first-of-its-kind interdisciplinary center focused on discovering novel treatments for orphan diseases. The Center will bring together, without institutional walls, all necessary approaches to attacking and treating orphan diseases: establishing dedicated research support facilities, translating findings into therapies, fostering targeted grant awards, and educating physicians and researchers.
In a new study, researchers from the Perelman School of Medicine at the University of Pennsylvania suggest that Alzheimer’s disease-like neurodegeneration may be initiated or accelerated following a single traumatic brain injury, even in young adults.
Jill M. Baren, MD, has been named chair of the department of Emergency Medicine at the Perelman School of Medicine at the University of Pennsylvania, effective July 1, 2011. A member of Penn’s medical faculty since 1997, she is a professor of Emergency Medicine and holds a secondary appointment as professor of Pediatrics, seeing patients at both the Hospital of the University of Pennsylvania and the Children’s Hospital of Philadelphia.
A new study from the Perelman School of Medicine at the University of Pennsylvania indicates that the so-called “rule of rescue” – whereby clinicians are prone to try to save their own patients as opposed to opening up a bed for a new patient – often prevails in the ICU.
After weathering the stresses of military life and the terrors of combat, soldiers find themselves overwhelmed by the transition back into civilian life. Many have already survived one suicide attempt, but never received the extra help and support they needed, with tragic results. A team of researchers found that veterans who are repeat suicide attempters suffer significantly greater mortality rates due to suicide compared to both military and civilian peers.
Chi Van Dang, MD, PhD, a renowned cancer biologist and hematologist-oncologist, has been appointed director of the Abramson Cancer Center of the University of Pennsylvania, effective September 1, 2011.
More than 200,000 people are treated for cardiac arrest in United States hospitals each year, a rate that may be on the rise. The findings are reported online this week in Critical Care Medicine in a University of Pennsylvania Perelman School of Medicine-led study.
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