Researchers at UT Southwestern Medical Center have discovered how a bacterium that infects people after they eat raw or undercooked shellfish creates syringe-like structures to inject its toxins into intestinal cells. The findings, published in Nature Communications, could lead to new ways to treat food poisoning caused by Vibrio parahaemolyticus.
Women with chronic hypertension and diabetes who were enrolled in an award-winning program for 12 months after childbirth were more likely to keep follow-up health care visits, which in turn led to improved care, according to initial findings of the program published in The Joint Commission Journal on Quality and Patient Safety.
A team led by UT Southwestern Medical Center researchers has discovered a protein that appears to be pivotal for traumatic heterotopic ossification (HO), a condition in which bone forms in muscles, tendons, and other soft tissues after traumatic injury or surgery. The findings, published in Science Advances, could yield new ways to prevent this common complication, the researchers say.
Patients with sickle cell disease (SCD) who undergo total knee replacement are at higher risk for complications than non-SCD patients, according to a large-scale, retrospective study by researchers from UT Southwestern Medical Center and the University of Calgary. The study was published in Archives of Orthopaedic and Trauma Surgery.
The use of abdominal ice packs is a safe and effective way to help manage postoperative pain for patients who have had laparoscopic hysterectomies, an investigation by UT Southwestern clinicians has found.
Susan Hedayati, M.D., Director of Clinical and Population Health Research in Nephrology at UT Southwestern, has spent a career investigating the links between kidney disease and depression and developing methods to improve care from a patient-centric perspective for those with chronic kidney disease.
New technologies that can capture subtle changes in a patient’s voice may help physicians diagnose cognitive impairment and Alzheimer’s disease before symptoms begin to show, according to a UT Southwestern Medical Center researcher who led a study published in the Alzheimer’s Association publication Diagnosis, Assessment & Disease Monitoring.
Spring marks the arrival of baseball, and with it the risk of elbow injuries among young players. Tears or ruptures of the ulnar collateral ligament (UCL) are the most common elbow injury among baseball players from youth leagues to the major leagues, especially pitchers. The most severe cases require reconstructive surgery, commonly known as Tommy John surgery.
Multiple studies have demonstrated that Black patients are significantly less likely than white patients to undergo invasive cardiovascular procedures. Prior research also has demonstrated substantial racial disparities in the use of implantable cardioverter-defibrillators (ICDs) that can be lifesaving for those at high risk for sudden cardiac death.
About 1 million people in the United States have Parkinson’s disease, a progressive neurological disorder that ranks second to Alzheimer’s among the most common neurodegenerative diseases. While many tend to associate Parkinson’s with hand tremors, it can cause a broad range of symptoms, affecting both motor and nonmotor functions.
Researchers led by a team at UT Southwestern Medical Center have created a statistical model to identify standards for typical, high, or low rates of bleeding after pediatric tonsillectomies. The findings, published in JAMA Otolaryngology-Head & Neck Surgery, could help doctors and hospitals improve outcomes for the third-most common pediatric surgery in the U.S.
After a school shooting like the one that occurred in Nashville, parents may find themselves trying to navigate difficult conversations with their children. What to say is just as important as what not to say, according to experts at UT Southwestern Medical Center. Children are naturally curious and may have questions, or they may be worried about their own safety.
Researchers at UT Southwestern Medical Center have been approved for an $18 million funding award from the nonprofit Patient-Centered Outcomes Research Institute (PCORI) to investigate ways to improve postpartum health among primarily low-income Black and Hispanic women.
A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases. The study, published in Nature Communications, offers key insights that could help identify new treatments for patients.
Patients with a family history of age-related macular degeneration (AMD), the leading cause of permanent vision loss in those older than 60, should visit an ophthalmologist by age 55 to be screened for signs of the disease, advises an expert at UT Southwestern Medical Center.
Patients overwhelmingly prefer to receive test results as soon as they are available on online medical portals, even if it means viewing the results prior to discussing them with their doctor, a new study co-led by researchers at UT Southwestern and Vanderbilt University medical centers reports.
Nearly 100% of UT Southwestern Medical School students matched to residency programs – well above the national average of 94% – including about half who matched to hospitals affiliated with U.S. News & World Report's top 25 medical schools, including UT Southwestern. More than 100 matched to Texas programs.
Ten scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center have been awarded nearly $15 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to advance research on a wide range of cancer issues.
The shift to daylight saving time disrupts the body’s biological clock, affecting sleep patterns and how we function. A UT Southwestern Medical Center neuroscientist explains why.
UT Southwestern Medical Center has established the Beth Levine, M.D. Prize in Autophagy Research, an annual award and lecture for exceptional scientists who have made significant contributions to the field of autophagy.
Researchers at UT Southwestern Medical Center have discovered how healthy bacteria can escape the intestine, travel to lymph nodes and cancerous tumors elsewhere in the body, and boost the effectiveness of certain immunotherapy drugs. The findings, published in Science Immunology, shed light on why antibiotics can weaken the effect of immunotherapies and could lead to new cancer treatments.
A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn’t receive this treatment, UT Southwestern researchers report in a new study. The findings, published in Cell Metabolism, could lead to effective treatments for acute alcohol intoxication, which is responsible for about 1 million emergency room visits in the U.S. each year.
How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT Southwestern Medical Center researchers shows.
Cell membrane protrusions called blebs that typically signify the end of life for healthy cells do the opposite for melanoma cells, activating processes in these cells that help them to survive and spread, a UT Southwestern study suggests.
It’s almost that dreaded time of year, when spring and summer allergies can make life miserable for many. Ashley Agan, M.D., Assistant Professor in the Department of Otolaryngology – Head and Neck Surgery at UT Southwestern Medical Center, said steps can be taken to control symptoms and prevent infections.
UT Southwestern biochemist Zhijian “James” Chen, Ph.D., famously identified the cGAS enzyme pathway that alerts the human immune system to disease-causing invaders like viruses. Since then, researchers have found that cGAS signaling is an ancient, conserved defense strategy stretching from bacteria to mammals. A new study from the Chen lab published in Nature reports a novel mechanism bacteria use to enhance the effectiveness of the cGAS-mediated immune response.
As a child in Beirut, Ahmad Anouti, M.D., endured dozens of medical procedures, hundreds of medications, and numerous setbacks before a liver transplant at age 16 saved his life. Today, Dr. Anouti is a postdoctoral research fellow at UT Southwestern Medical Center specializing in hepatology.
Business consultant, attorney, and investor Debra Hunter Johnson, founder of Reciprocity Consulting Group, will chair the UT Southwestern Medical Center President’s Advisory Board for the 2023-2025 term.
Researchers at UT Southwestern Medical Center have discovered the first molecular biomarker for acquired generalized lipodystrophy (AGL), a rare disorder in which fat deposits are destroyed, causing patients to have dangerously low body fat, signs of accelerated aging, and severe metabolic diseases including diabetes and fatty liver.
Two classes of drugs prescribed off-label for some patients with Type 1 diabetes can provide significant benefits but also come with health concerns, according to a study by UT Southwestern Medical Center researchers. The findings are published in The Journal of Clinical Endocrinology & Metabolism.
Young adolescents face different challenges in pregnancy compared with their older teenage peers and adults that are sometimes exacerbated by high rates of obesity, a new study by UT Southwestern researchers suggests. The findings, published in the American Journal of Obstetrics & Gynecology MFM, could highlight at-risk populations for targeted prevention efforts.
Technology can be a pain in the neck, leading to what’s known as “tech neck,” chronic pain that results from prolonged use of mobile phones, tablets, and other electronic devices.
UT Southwestern Medical Center researchers have mapped gene control elements in specialized cardiac cells responsible for coordinating heartbeats. The findings of the genome exploration study, published in The Journal of Clinical Investigation, provide insight into how heartbeats are regulated and could impact diagnosis and risk prediction for a variety of common arrhythmias.
Utilizing artificial intelligence (AI) along with traditional pathology offers promise for swiftly developing treatment plans for patients with non-small cell lung cancers, a team led by UT Southwestern Medical Center researchers discovered.
Patients’ satisfaction with their physicians may influence their decisions to undergo bariatric surgery, according to a multicenter study involving UT Southwestern and the UTHealth School of Public Health published in JAMA Network Open.
The severity of a lung disease associated with e-cigarettes in teens decreased during the COVID-19 pandemic, but hospitalizations from the disease continued to mount, according to a study of more than three dozen patients by UT Southwestern researchers published in Pediatric Pulmonology.
UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery. The findings, reported in Cell, could lead to new ways of controlling gene regulation and may one day lead to new treatments for a broad array of diseases.
A study of retired professional football players by researchers at UT Southwestern Medical Center found that their cognitive abilities did not differ significantly from a control group of similarly aged men who did not play football, nor did those abilities show significant change over one to five years. The findings were published in Brain Injury.
Slipping on ice or tripping over a curb can result in broken bones or more serious injuries. To avoid taking an unexpected tumble, it’s important to be aware of your surroundings and watch where you’re walking, a UT Southwestern Medical Center orthopedist advises.
A study by UT Southwestern researchers has identified three factors that increase the risk that bunion surgery will fail to fix this painful foot condition. The findings, published in The Journal of Foot and Ankle Surgery, provide information that surgeons can use to counsel patients considering this elective procedure.
Hepatocellular carcinoma (HCC), the most common type of liver cancer, can place a significant financial burden on patients, according to an analysis led by a researcher at UT Southwestern Medical Center.
UT Southwestern physician-scientist Hesham Sadek, M.D., Ph.D., has received the prestigious National Institutes of Health (NIH) Outstanding Investigator Award to support his ongoing research into mechanisms behind heart regeneration that could lead to treatments for heart failure.
Two of UT Southwestern’s Howard Hughes Medical Institute researchers in biochemistry and molecular biology will lead separate teams as part of HHMI’s Emerging Pathogens Initiative (EPI) targeting infectious diseases that pose a threat to human health.
Patients undergoing cataract surgery typically have their natural lens replaced with an artificial intraocular lens (IOL). But complications occasionally arise that require the placement of a more surgically challenging secondary IOL. Several techniques are available for secondary IOL placement, and each has its advantages and disadvantages.
Editing a gene that prompts a cascade of damage after a heart attack appeared to reverse this inevitable course in mice, leaving their hearts remarkably unharmed, a new study by UT Southwestern scientists showed. The findings, published in Science, could lead to a new strategy for protecting patients from the consequences of heart disease.
Internationally recognized epidemiologist Saad B. Omer, M.B.B.S, Ph.D., who currently directs the Yale Institute for Global Health, has been appointed the inaugural Dean of the Peter O’Donnell Jr. School of Public Health at UT Southwestern Medical Center.
James Collins III, Ph.D., Associate Professor of Pharmacology at UT Southwestern Medical Center, will receive the 2023 Edith and Peter O’Donnell Award in Biological Sciences from The Academy of Medicine, Engineering and Science of Texas (TAMEST) for broadening understanding of schistosomiasis.
Patients considering LASIK vision correction surgery should weigh the risks as well as benefits and see a doctor who can assess whether they are a good candidate for the procedure, according to an ophthalmologist at UT Southwestern Medical Center.
Cooling brain tumor cells to stop them from dividing without killing healthy cells extended the survival of glioblastoma (GBM) animal models dramatically in a study led by a UT Southwestern resident. The findings, published in Science Advances, could lead to new treatments for this aggressive and deadly cancer.
An innovative virtual reality (VR) training tool – developed by UT Southwestern Medical Center’s Department of Emergency Medicine in partnership with UT Dallas – could soon play a major role in helping physicians recognize and respond to potentially violent patient encounters.
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