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An international study led by researchers at UCLA has found that a personalized vaccine targeting glioblastoma, the deadliest form of brain cancer, may help people live longer. Nearly 30 percent of people in the current trial have now survived for at least three years after receiving the vaccine.

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Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA a have been awarded a $12M grant from the California Institute for Regenerative Medicine – also known as CIRM – to initiate a phase 1 clinical trial to test a novel cancer treatment for advanced-stage lung cancer.

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UCLA researchers lay out the probabilities that a person will develop Alzheimer’s disease dementia based on age, gender and the results of biomarker tests, which can detect the presence of certain protein fragments in brain and spinal fluid or for brain cell changes linked with the disease.

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In a first-of-its-kind finding, a new stroke-healing gel helped regrow neurons and blood vessels in mice with stroke-damaged brains

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A new algorithm more accurately predicts which people will survive heart failure, and for how long, whether or not they receive a heart transplant. The algorithm would allow doctors to make more personalized assessments of people who are awaiting heart transplants, which in turn could enable health care providers to make better use of limited life-saving resources and potentially reduce health care costs.

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Researchers have developed updated guidelines for classifying a serious form of skin cancer called invasive melanoma.

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FINDINGS UCLA-led research suggests that receiving support from friends and acquaintances can help prevent black men who have sex with men from becoming infected with HIV. BACKGROUND Black men who have sex with men have disproportionately high rates of HIV infection. While social connections are known to influence the behaviors that influence people’s risk for HIV, little is known about whether they affect the risk for becoming infected with HIV.

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The 3 Wishes Project aims to improve the end-of-life experience in the intensive care unit by fulfilling small wishes for dying patients.

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For years, researchers have known that a gene called EAK-7 plays an important role in determining how long worms will live. But it remained unclear whether the gene had a counterpart in humans and – if it did – how that human version would work. Now, researchers led by UCLA’s Dr. Paul Krebsbach are the first to characterize the mechanism of the human equivalent, which they call mammalian EAK-7, or mEAK-7.

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The UCLA Division of Geriatrics has received a five-year, $13.6 million award from the Patient-Centered Outcomes Research Institute (PCORI) to compare Alzheimer’s disease care delivered through a health system with care that occurs in a community-based setting.

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UCLA researchers have identified for the first time a receptor in the cell membranes of the heart that plays a key role in repairing damage caused by heart attack and cardiac arrest. The discovery of the receptor, in mouse and rat hearts, explains the mechanisms behind the protective effects of lipid emulsion and could improve treatments for humans with heart disease.

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About 2 percent of pregnant women suffer a severe form of morning sickness known as hyperemesis gravidarum, or HG. The hallmark symptoms include rapid weight loss, malnutrition and dehydration due to unrelenting nausea and vomiting. It is the second-leading cause of hospitalization during pregnancy. Researchers are finally getting some answers on what causes it.

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Anthrax, plague and tularemia are three potent agents terrorists would be likely to use in an attack, according to the Centers for Disease Control and Prevention. Each is highly and quickly lethal to humans. But there are no licensed vaccines for tularemia and plague, and although there is an anthrax vaccine, it requires a burdensome immunization schedule and has severe side effects.

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Left untreated, its sleep-disturbing effects can lead to life-threatening cardiovascular problems, including high blood pressure, chronic heart failure, atrial fibrillation and stroke. And for women, the impact can be even more severe.

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The U.S. Food and Drug Administration recently announced that it is cracking down on the illegal sale of e-cigarettes to minors, including those under the Juul brand and other similar emerging brands such as myblue and KandyPens. The agency is also creating a Youth Tobacco Prevention Plan to stop the use of, and access to, Juul and other e-cigarettes. UCLA's Dr. Holly Middlekauff created an educational video to help teens understand the facts about e-cigs.