Researchers at the University of Pennsylvania Medical Center show for the first time that brain trauma alters the specific pathways for recognizing DNA damage and initiating the DNA repair process.
1. DNA Catapult Springs Recombination Reaction Forward 2. Possible Driver for Breast Cancer Metastasis Discovered 3. Less is More in Short-term Memory Triage.
Naturally occurring insertions in sperm-cell DNA is 100 times more common than the suggested FDA limit for gene-therapy studies, a Penn geneticist estimates.
The latest developments in gene therapies, including those for AIDS, cardiovascular disease, and cancer, will be presented at the 2nd Annual Meeting of the American Society of Gene Therapy in Washington, DC from June 9 - 13.
1. Structure of HDL Cholesterol Determined 2. Cellular Implants Explored for Brain Trauma 3. Cardiovascular Phenomenon Explained After 150 Years
Head size correlates statistically with intelligence, and men's heads, like their bodies, are bigger than women's. Men should be more intelligent than women - but they are not. Now, researchers report an explanation for the conundrum: Women have a higher proportion of gray matter - computational tissue - to cranial volume than men.
Bioengineers at the University of Pennsylvania have designed an artificial capsule that imitates many of the qualities of natural cells, with has wide-ranging applications.
Researchers at the University of Pennsylvania Medical Center have created the largest protein from scratch, with both a stable and predictable shape. Applications include manufacturing entirely new polymers for industrial catalysts and creating new pharmaceuticals.
Researchers at Penn Medical Center have discovered how proteins called chaperonins protect cells from harm by sequestering and unfolding misshapened proteins.
Researchers have uncovered a biochemical connection between presenilin, a molecule involved in the development of Alzheimer's disease, and another protein that controls crucial aspects of developmental biology.
Scientists have identified a new human gene that may figure prominently in the regulation of cholesterol levels in the body. When the gene was experimentally overexpressed in mice, levels of HDL cholesterol - the "good" cholesterol - dropped to nearly undetectable levels, a condition associated with high cardiovascular disease risk in humans.
A Phase-II study performed by a team of researchers at the University of Pennsylvania Medical Center has found that a minimally invasive technique known as chemoembolization may double the survival time of adult patients with colon cancer that has spread to the liver.
In this age of molecular biology, scientists would like to know whether and how evolution operates at the molecular level in an organism's DNA. Now, in a new study, researchers have discovered a molecular mechanism that may be a significant driver of evolution in humans and other mammals.
The so-called "super aspirins," or COX-2 inhibitors, may have a downside, one that could not have been detected in the clinical trials performed to date. A new study suggests that aspects of their action in the body may elevate the risk of heart attacks, strokes, and other adverse cardiovascular events.
Using a unique combination of innovative technologies, scientists have demonstrated the ability to introduce therapeutic genes into the body and then, further, to precisely control the activity of those genes with a drug that could be given as a simple pill.
For over 50 million disabled individuals and the clinicians that care for them, varying importance placed on cognitive and motor skills is critical to treatment choices. Researchers at the University of Pennsylvania Health System have developed the Features Game to help close the gap between different patient and clinician values.
A new gene therapy treatment could reverse the feebleness associated with old age, fully restoring the muscular strength of youth, or counter the muscle-wasting effects of some muscular dystrophies, according to University of Pennsylvania Medical Center researchers.
Free-radical activity was found to be roughly doubled in the frontal and temporal lobes of the brains of people who had died of Alzheimer's disease when compared to the same regions of normal brains, University of Pennsylvania Medical Center researchers reported in the December issue of the FASEB Journal.
A new study reveals pivotal characteristics of the disease mechanism underlying a hereditary dementia similar to and often confused clinically with Alzheimer's disease.
Sexual abuse of boys appears to be underrecognized, underreported, and undertreated, according to a new study by researchers at the University of Pennsylvania School of Medicine.
Promising new treatments for adult-onset diabetes hinge on the action of a receptor that controls how cells respond to the hormone insulin. Researchers at the University of Pennsylvania Medical Center have now revealed a key step in the regulation of this receptor.
Researchers at the University of Pennsylvania Medical Center have found a link between messenger RNA and the protein involved in spinal muscular atrophy, the leading genetic cause of infant death.
The University of Pennsylvania School of Medicine has been awarded a five-year grant by the National Cancer Institute totaling nearly $10 million to investigate genetic susceptibility to hormone-related cancers.
University of Pennsylvania School of Medicine researchers say that the current practice of administering antibiotics to at-risk patients to prevent the onset of heart-valve disease resulting from dental work is unnecessary, according to results of their latest study.
University of Pennsylvania Medical Center physicians have developed a list of clinical guidelines to aid physicians in advising patients about herbal products as therapeutic agents.
Researchers at the University of Pennsylvania Medical Center have discovered that antibodies to a common inflammatory-response protein can prevent relapses in an animal model of human multiple sclerosis. This research represents another possible therapy for MS patients.
University of Pennsylvania researchers find negative bias in newspaper coverage of managed care. Two-thirds of print articles analyzed provided a negative representation of this growing form of health insurance.
Researchers at the University of Pennsylvania Medical Center today were awarded patent number 5,824,311 for a new technology that has shown the potential in laboratory studies to cure breast and other major cancers linked to certain abnormal genes.
Using computer intelligence, researchers at the University of Pennsylvania Medical Center have developed a "smart" ICU system that improves vital-sign monitoring of critically-ill patients.
A new study from the Penn Medical Center shows that the common practice of self-prescription by physicians begins at the outset of one's medical career. According to the study, more than half, or 52%, of the residents surveyed reported that they prescribed medications for themselves.
Research at the University of Pennsylvania Medical Center has recently added some revealing clues as to how protein folding is managed and corrects some misconceptions about how rapidly the process occurs.
In mice genetically manipulated to develop atherosclerosis, scientists have for the first time conclusively demonstrated that vitamin E confers potent protection from the disease.
Researchers at the University of Pennsylvania Medical Center have now found a way to make brain cancer cells more receptive to radiation treatment --by 60-fold in some cases.
Three story ideas based on ongoing research at the University of Pennsylvania Medical Center: 1.A Role for Prolactin in Breast Cancer 2.Proteins Deep Inside the Nucleus Hold Clues for Two Diseases 3.Tightly Controlled Protein Destruction Drives the Cell Cycle
In cancers based in unusual locations (in the lining of the lung-mesothelioma- or in lymph nodes), researchers have shown the advantages of using positron emission tomography over structural imaging, including X-Ray, magnetic resonance imaging, and computerized tomography.
How the brain works and why it malfunctions remains a mystery, but an advanced brain imaging agent developed at Penn could be a key to understanding brain disorders like Parkinson's/Alzheimer's. The finding of this agent is being honored by the EJNM with the Award for Best Science Paper in 1997.
Researchers at the University of Pennsylvania Medical Center have demonstrated for the first time how a biochemical channel important for the exchange of cell nutrients links the multiple layers of the myelin sheath to the outside space. This research has implications for all demyelinating diseases, including multiple sclerosis.
A genetic mutation associated with prostate cancer has been identified, for the first time, by scientists at the University of Pennsylvania Cancer Center. The researchers found that men who carry this mutation in the CYP3A4 gene had a more advanced prostate tumor than those without the mutation
How the brain responds to injury -- in terms of the cellular cascade that leads to cell death -- is poorly understood. Looking at a particular pattern of cell death called apoptosis, or programmed cell death, researchers at the University of Pennsylvania Medical Center have discovered that in a rat model this kind of deleterious cellular destruction continues for weeks after the initial trauma.
Developmental biologists all over the world are earnestly studying 2,000 new mutants of zebrafish -- and adding new ones to the list -- to determine what role they play in complex biochemical pathways. Researchers at the University of Pennsylvania Medical Center have identified new mutants important in the first steps that control the dorsoventral -- back to abdomen -- arrangement of embryonic tissues, a process called patterning.
Science Tip Sheet: Three story ideas based on ongoing research at the University of Pennsylvania Medical Center.
Penn Scientists have developed an unprecedented method to quickly and accurately assess lung function in less than 10 minutes with a new mass spectrometer. This technique measures trace gas tensions in small blood and breath samples to determine if the lungs are working properly to pinpoint pulmonary disease and target therapy.
Scientists at the Penn Medical Center and NIH identified a new molecular target that could lead to novel therapies for ischemic cardiovascular disease. The research team found that a receptor for adenosine found on the surface of ventricle cells exerts a powerful, sustained protection against injury during exposure to ischemia.
A major international study by cardiologists has shown that the addition of tirofiban into the medical management of patients with unstable angina reduces their risk of death by as much as 47%.
In March, a New York man became the first U.S. person to die from infection by a bacteria resistant to vancomycin, the powerful antibiotic physicians turn to when others fail. Now, scientists report discovery of a novel form of vancomycin that advances the search for more effective versions of the antibiotic.
Researchers at the University of Pennsylvania Medical Center have designed a novel test that effectively predicts a patient's risk for developing a common life-threatening heart-rhythm abnormality following coronary-artery bypass surgery.
Reducing post-operative pain can be as easy as taking pain medication before surgery. Dr. Allan Gottschalk and his colleagues have found that administering preemptive analgesia in patients prior to surgery decreases pain afterward. Their findings could potentially change the standard of care for some surgical patients.
Do antioxidant vitamins protect healthy people from free-radical damage? Can some diseases be slowed or reversed with antioxidants? Perhaps surprisingly, no measurement technique has existed to easily and directly assess the corrosive effects in individuals of these highly reactive types of oxygen. Now, scientists have developed such a test.
For the first time, researchers at the University of Pennsylvania Medical Center have confirmed that bone--similar to that found in the human skeleton--is present in a substantial portion of diseased heart valves.This finding could lead to the development of therapies to prevent or treat heart-valve disease.
1.Smell Loss an Early Indicator of Alzheimer's and Parkinson's Diseases; 2.Newly Found Endothelial Receptor Implicated in Both Heart Disease and AIDS; 3. DNA Vaccination Lowers HIV-1 Viral Load in Infected Chimpanzees
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