The only known adults in the world who possess a genetic mutation that prevents their bodies from producing leptin may lead to a new way of fighting fat. After leptin therapy, the adults' dramatic weight loss suggests that leptin offers promise for treating obesity.
Researchers at UCLA's Jonsson Cancer Center and in the Department of Urology have demonstrated for the first time that they can locate difficult-to-detect prostate cancer metastases in laboratory models, a discovery that could lead to safer and more effective gene-based treatments for advanced prostate cancer.
New research at UCLA's Jonsson Cancer Center provides the first comprehensive examination of quality-of-life issues faced by long-term lung cancer survivors.
UCLA researchers are using brain scans to predict the effectiveness of antidepressants within days of treatment, cutting weeks off the time needed to evaluate the effectiveness of the medicine. The results could mean faster relief of symptoms for many of the millions who suffer from acute depression.
UCLA scientists have developed a fast new way to image how genes misfire in a mouse model of Parkinson's disease. The model may help identify the genes that cause autism and schizophrenia.
Using fruit flies genetically engineered to imitate the molecular symptoms of human dementia, UCLA neurologists identified a new way that the disease kills brain cells. The findings suggest that the fly model could inexpensively speed the development of drugs to treat Alzheimer's disease.
A new UCLA study shows efforts to teach parents that antibiotics are not necessary to treat their child's cold are failing to reach the Latino and Asian communities, and that educational campaigns need to be revamped to connect with these groups. The findings, being presented at the Pediatric Academic Societies annual meeting in Baltimore, MD, also show that despite current educational efforts, physicians continue to prescribe antibiotics if they feel pressure from parents.
UCLA researchers retrospectively reviewed survival rates of hepatitis B liver transplantation patients. Their findings show that a combination of two drug therapies improved patient survival rates and that long-term treatment dramatically decreases recurrence of the disease.
An experimental vaccine for brain cancer has shown promising results in preliminary investigations at UCLA's Jonsson Cancer Center.
A history of childhood sexual abuse overshadows all other factors that place a woman at risk for contracting HIV infection, suggests a new UCLA and Drew University study.
UCLA AIDS Institute researchers discovered that African strains of HIV infected two American infants as early as 1994. The scientists also found that multi-drug "cocktails" - available for children only since 1997 -- successfully combat the spread of HIV in most patients.
Dr. Daniel Geschwind, UCLA assistant professor of neurology, has received a five-year, $6M grant from the National Institute of Mental Health to expand scientific and community groups' efforts to identify the genes that cause autism.
For the first time, UCLA researchers have determined that genetics plays a significant role in shaping brain structure and influences the brains of left-handed and right-handed people differently.
A new UCLA study shows strong evidence that "Sweaty Palms," is genetic. Previously this embarrassing and often debilitating disorder was thought to be stress related and not taken seriously by the medical community. Family members with disorder available for interviews. B-roll of the corrective surgery for sweaty palms also available.
UCLA geneticists have discovered the first evidence that migraine with aura is a hereditary condition. The new findings will enable researchers to isolate the gene that predisposes people to the painful headache disorder.
For the first time, UCLA AIDS Institute scientists have demonstrated in an animal model that cocaine use dramatically accelerates the spread of HIV infection. Offering a useful tool for examining other HIV-related risk factors.
Since "time is brain" when treating stroke victims, UCLA Medical Center researchers are encouraged by a pilot study showing magnesium sulfate administered early in the field by paramedics may actually protect the threatened brain and lead to a better recovery.
In one of the largest national studies of its kind, UCLA researchers found that both caregiver and patient health care costs rise as symptoms worsen in patients with Alzheimer's disease. Costs can rise to over $30,000 for a six-month period. Early treatment may improve patients' quality of life and lower costs.
A new UCLA School of Public Health study offers the first scientific evidence that sports stars and other public figures exert a positive influence in the lives of teen admirers.
UCLA scientists have discovered the brain mechanism that causes learning disabilities in neurofibromatosis 1, an inherited disease marked by disfiguring tumors. The discovery will lead to new treatments for the disease, which affects nearly one million people worldwide.
UCLA and Finnish researchers have identified a genetic mutation for lactose intolerance, a painful digestive condition that afflicts some 30 million to 50 million North Americans, 75 percent of African Americans and 90 percent of Asian Americans.
UCLA scientists have created the first technique to image the onset of Alzheimer's disease in the living brain - before the disorder attacks brain cells. The method will allow doctors to monitor the disease as it unfolds, speeding diagnosis and new treatments.
Long-term breast cancer survivors report excellent quality of life many years after treatment, but the use of chemotherapy and tamoxifen in addition to surgery may result in decreased physical functioning over time, according to a study published in TuesdayÃs (Jan. 2) issue of the peer-reviewed Journal of the National Cancer Institute.
UCLA researchers have discovered that the AIDS epidemic significantly amplifies tuberculosis (TB) outbreaks, often doubling the number and frequency of resulting TB cases. However, their research also shows how strong TB treatment programs can curb HIV's effect - a result of particular importance in developing countries battling both diseases.
UCLA research shows that positron emission tomography (PET) scans of the brain can accurately detect early Alzheimer's disease up to 95 percent of the time - leading to prompt medical treatment for the debilitating disease.
New UCLA AIDS Institute research reveals that stress enables HIV to spread more quickly in infected persons and prevents antiretroviral drugs from restoring immune system function. The UCLA study is the first to pinpoint the molecular mechanisms linking stress and HIV infection.
A genetic analysis of a protein believed to affect the formation of blood vessels has proved that Thrombospondin-1 does indeed regulate a tumor's ability to form the independent blood supply that cancers need to grow and thrive, UCLA researchers report.
The number of drug-resistant HIV cases has already reached epidemic proportions in San Francisco, but transmission of drug-resistant strains is not to blame, reports a new UCLA/UCSF study.
Researchers at UCLA's Jonsson Cancer Center have discovered a unique gene modification in adult human cancer cells that could provide insight into the cause of certain types of lymphoma and possibly other cancers.
For the first time, UCLA scientists have identified the small group of brain cells believed to originate breathing in mammals. Reported in the September issue of Nature Neuroscience, their discovery could lead researchers to new approaches to addressing serious health problems, such as sleep apnea and sudden infant death syndrome.
UCLA pharmacology chair and Norton Simon Professor Michael E. Phelps, creator of the positron emission tomography (PET) scanner has earned two of the medical field's most prestigious peer awards.
Researchers at UCLA's Jonsson Cancer Center have shown for the first time that immunotherapy delivered via gene therapy may prove to be a potent weapon in the fight against locally advanced prostate cancer.
UCLA researchers have determined that too much of a human sex gene can convert an embryo from male to female, often resulting in ambiguous genitalia. The findings offer new hope for parents whose babies are born with genital malformations -- and valuable diagnostic information for physicians who make decisions about the newborn's gender.
The lung cancer program at UCLA's Jonsson Cancer Center has been designated a Specialized Program of Research Excellence by the National Cancer Institute, making it one of six programs nationwide to receive national recognition and substantial research funding.
UCLA physicians announced that three young boys - each born with a defective immune system like the "boy in the bubble" - underwent umbilical-cord blood transplants from unrelated donors, and two years later, are seemingly cured of their immunodeficiencies. (Journal of Pediatrics, 4-01)
An experimental pill for a common form of adult leukemia continues to show great promise in early studies. (NEJM, 4-5-01)
UCLA AIDS Institute researchers solve mystery of how HIV exploits the human immune system to hibernate and avoid anti-AIDS drugs -- then resurface years after initial infection. (Nature Medicine, 3-01)
A UCLA study finds that HIV-infected youth participating in an AIDS- intervention program willingly cut their high-risk sex by 82 percent and lowered their drug use by a third. (Am. J. of Public Health, 3-01)
For the second consecutive year, scientists at UCLAÃs Jonsson Cancer Center have earned more CaP CURE prostate cancer research awards than any other single institution nationwide. In all, 10 UCLA scientists will receive grants this year totaling more than $1 million.
A new molecular imaging center that will develop innovative ways to see gene-based therapies at work in the human body was launched at UCLA's Jonsson Cancer Center. The $9.8M UCLA Center for In Vivo Imaging in Cancer Biology is the first such molecular imaging center on the West Coast.
An experimental targeted therapy for chronic myelogenous leukemia continues to show promise in early testing, and it may help to battle the disease even at its most aggressive and deadly stage, according to a researcher at UCLA's Jonsson Cancer Center.
Athletes hoping to boost their performance by consuming an over-the-counter dietary supplement known as "andro" may actually increase their risk of testing positive for banned steroid use.
For 7-year-old Kyle Schepens - near death due to a virulent form of heart disease - a new and surprisingly hopeful treatment allowed him to celebrate his eighth birthday. (Heart and Lung Transplantation, 11-00)
Scientists from UCLA and the University of Cambridge, United Kingdom, report a revolutionary advance in pain medicine that promises to deliver painkillers directly to the affected area of the body, in smaller doses and with fewer side effects.
New research suggests that adding an experimental drug to antiviral therapy may help persons with advanced HIV infection rebuild their immune systems faster than antiviral therapy alone.
For parents worried about the consequences of concussion in their children, a new UCLA study suggests that mild traumatic brain injury may impair a child's brain's ability to develop to its fullest potential.
In an effort to shed light on a largely unexplored disease and provide more effective treatments, officials from UCLA's Jonsson Cancer Center today launched a state-of-the-art liver cancer center.
UCLA AIDS Institute researchers have found that HIV may have an easier time penetrating and replicating itself through the gut than the circulatory system, explaining why unprotected oral and anal sex with an infected partner holds even greater risk than previously believed (AIDS).
UCLA's Jonsson Cancer Center scientists have discovered a novel way to follow gene therapy through the body. The technology essentially renders the body transparent and will allow physicians to determine whether gene therapies reach targeted cells and work as they should (Nature Medicine, 8-1-00).
Breast cancer survivors with severe menopausal symptoms can find significant relief through a comprehensive program that emphasizes supportive care in addition to medication, according to a study by UCLA's Jonsson Cancer Center researchers (Journal of the National Cancer Institute, 7-5-00).
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