Scientists pinpoint the molecular epicenter of deep-sleep regulation. The findings, based on research in mice, identify a gene that makes a protein that regulates delta waves—electrical signals between neurons that occur during the deepest phases of relaxation and are a hallmark of restorative sleep.
A new tool makes high-resolution imaging data on human tissues easier to understand and use
Spatial maps of melanoma reveal how individual cells interact as cancer progresses
Gunshot survivors experience serious increases in mental health disorders, substance use disorders, and pain in the year following a firearm injury Survivors’ family members also experience a rise in mental health disorders such as depression, anxiety, and PTSD in the year after loved ones’ injuries
COVID-19 experts discuss public and individual risk management during the transition into endemicity
Researchers describe a mechanism in mice that underlies local dopamine release in the brain
Bile acids, well known for their role in dissolving fats and vitamins, are also important players in gut immunity and inflammation.
Researchers have identified a new mechanism that regulates the permeability of the blood-brain barrier in mice
Memory may alter how we perceive the visual and auditory information we encounter
Researchers develop tool that “audits” the results of studies that examine interplay between variables.
Leonid Peshkin has developed a new model system aiming to illuminate the fundamentals of aging
Is omicron the beginning of the end of SARS-CoV-2’s evolutionary story or a mere a twist in the plot?
Some physicians are much more likely to deliver appropriate care than others, even in clinical situations where guidelines for appropriate care are clear. Notable—at times dramatic—differences were found across 14 common clinical scenarios representing seven specialties. The findings highlight the importance of understanding the reasons for these variations and developing ways to minimize them to improve the value of care.
Questions remain on which vaccine type to get, whether to mix and match types, and how soon after a breakthrough infection to get boosted. To untangle some of these uncertainties, Harvard Medicine News spoke with Jonathan Li, associate professor of medicine at Harvard Medical School and Brigham and Women's Hospital.
Research shows T cells offer protection even against new SARS-CoV-2 variants T cells shield against serious illness, hospitalization, and death from COVID-19 T cell-based vaccines may further boost protection from these critical immune players as the virus continues to shapeshift
• Researchers have identified a set of receptors shared across human, mosquito, and other animal cells for the eastern equine encephalitis virus (EEEV) and two related viruses, a crucial first step for developing preventive and curative treatments. • In experiments with cells and mouse models with a related virus, the scientists were able to prevent infection and disease progression using decoy molecules to hamper viral entry into cells. • In a 2019 outbreak of eastern equine encephalitis (EEE, or triple E) in New England, 30 percent of infected people died and half of those who survived had long-term neurologic damage. • Done between major outbreaks, this type of research into highly pathogenic viruses with pandemic potential can help improve preparedness for future outbreaks.
Study identifies racial and ethnic disparities in hospital mortality for COVID and non-COVID patients alike, highlights urgent need to address systemic inequities in health care and improve care for those who are impacted the hardest by the virus, directly and indirectly.
Researchers identify mechanism that explains how tissues form complex shapes that enable organ function
A new study shows that a toxin from the microbe that causes anthrax can silence multiple types of pain in mice.
Computational tools can help scientists understand how the brain makes split-second decisions
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