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Norma J. Nowak, PhD, a nationally recognized leader in genomic technology and cancer genetics research at Roswell Park Cancer Institute (RPCI), joined colleagues from the University of California, San Francisco, Comprehensive Cancer Center and Lawrence Berkeley National Laboratory in accepting the AACR Team Science Award at the 2008 annual meeting of the American Association for Cancer Research (AACR), April 12 - 16, in San Diego, CA.

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The Ovarian Cancer Research Fund has awarded a $900,000 research grant to Kunle Odunsi, MD, Department of Gynecologic Oncology, and his colleagues at Roswell Park Cancer Institute (RPCI) to collaborate on developing a promising vaccine to unleash the power of the immune system against cancer.

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Like most women with ovarian cancer, 44-year-old Christine Sable of Lancaster, Pennsylvania, did not discover she had the disease until it was in the advanced stages and had spread to other areas of the abdomen. "I knew my chances of recurrence were very high"”75 to 80 percent at that particular stage"”and that the disease would likely recur within a year or two," she says. "Once it recurs, it is difficult to cure."

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Vitamin D, often called "the sunshine vitamin", is not a vitamin at all, but rather a versatile hormone produced by the body in response to sunlight. Candace S. Johnson, PhD, at Roswell Park Cancer Institute (RPCI), is a key opinion leader and pioneer in vitamin D and cancer research.

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Clinical trials are the frontier for targeted cancer drugs. Roswell Park Cancer Institute recently opened one of only a few clinical research centers in the U.S. focused exclusively on cancer. The Clinical Research Center, under the direction of Alex A. Adjei, MD, PhD, the Katherine Anne Gioia Chair in Cancer Medicine, will accelerate the development of new and promising cancer therapies and expand treatment options for patients at Roswell Park and elsewhere. Dr. Adjei is a distinguished national leader in translational research, drug development, thoracic oncology and phase I clinical research programs.

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More than 60% of patients with bladder cancer are over 65 years old. For many of those patients, comorbidities preclude the possibility of open radical cystectomy. Robotic-assisted radical cystectomy offers a less-invasive alternative that confers several benefits, including less blood loss and 40-50% less pain, on average, than patients tend to experience with open cystectomy. In addition, recovery time averages about two to four weeks, compared with six to eight weeks for open cystectomy.

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Roswell Park Cancer Institute (RPCI) officially opened its $2.6 million Clinical Research Center today, dedicating the facility to the development of new cancer therapies while providing more treatment options for patients through clinical trials. The Center is one of only a few clinical research centers in the U.S. to focus exclusively on cancer and will provide the foundation for the Institute's expanding phase I and drug development clinical research.

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A novel anti-angiogenic agent, TRC105 (also known as c-SN6j), developed in the laboratory of Ben K. Seon, PhD, Department of Immunology, Roswell Park Cancer Institute (RPCI) has the potential to be an effective agent for the treatment of solid tumors. The United States Food and Drug Administration (FDA) approved TRC105 as an Investigational New Drug (IND).

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Women who smoke and have a specific genetic makeup are at significant risk for the development of breast cancer, according to a recent study published by the journal Cancer Epidemiology, Biomarkers and Prevention.

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Cancer patients have significant concerns about legal-medical issues that are not being adequately addressed and impact the quality of their lives, according to a study conducted by Roswell Park Cancer Institute. Results of the study were published in a recent issue of Cancer and presented at the annual meeting of the American Psychological Association.

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The National Cancer Institute has awarded a five-year, $7.5 million Program Project Grant to Roswell Park Cancer Institute (RPCI) for translational research on the prevention of prostate cancer. Clement Ip, PhD, Distinguished Member and Head of Cancer Chemoprevention at RPCI, is the principal investigator.

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The Board of Directors of the Roswell Park Cancer Institute Corporation (RPCIC) today introduced Donald L. Trump, MD, as the new President and Chief Executive Officer of Roswell Park Cancer Institute (RPCI). He succeeds David C. Hohn, MD, who is credited with re-establishing the Institute as a leading cancer center during his 10-year administration.

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Scientists from the Translational Lymphoma Research Laboratory of Myron S. Czuczman, MD, Departments of Medicine and Immunology at Roswell Park Cancer Institute (RPCI), will present laboratory and preclinical findings of the effects of blocking CD52 antigen by using alemtuzumab, a previously FDA-approved monoclonal antibody, in rituximab-resistant cells, at the 2007 centennial meeting of the AACR, April 14-18, in Los Angeles, CA.

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Levels of an enzyme involved metabolizing chemotherapy may help patients with acute myeloid leukemia (AML) to be able to better tolerate chemotherapy, according to the results of research which will be presented by Kirsten Moysich, PhD, Department of Epidemiology, Roswell Park Cancer Institute (RPCI) at the 2007 centennial meeting of the American Association for Cancer Research (AACR), April 14-18, in Los Angeles, CA.

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Selenium may offer an intervention strategy for the treatment of prostate cancer according to results of a study from the laboratory of Allen Gao, PhD, which will be presented by Yan Hu, PhD, Departments of Medicine and Pharmacology and Therapeutics, Roswell Park Cancer Institute (RPCI) at the 2007 centennial meeting of the American Association for Cancer Research (AACR), April 14-18, in Los Angeles, CA.

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BUFFALO, NY "“ Vitamin D deficiency is common and cancer risk is higher among those individuals with low vitamin D levels, according to an analysis of research which will be presented at a symposium by Donald L. Trump, MD, President & CEO, Roswell Park Cancer Institute (RPCI) at the 2007 centennial meeting of the American Association for Cancer Research (AACR), April 14-18, in Los Angeles, CA.

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What a banner year it has been so far for Roswell Park Cancer Institute (RPCI). Since the beginning of 2007, the Institute has announced that a highly accomplished cancer researcher and his biomedical company are relocating to Buffalo, and that RPCI laboratory discoveries have led to the creation of a new life sciences spin-off company in Buffalo.

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Today, RPCI, joined by lung cancer experts representing 11 leading research institutions, announced the establishment of the first international lung cancer registry "“ the Stacey Scott Lung Cancer Registry.

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Principles and mechanisms of nanotechnology will be examined by Mohamed K. Khan, MD, PhD, NanoBiotechnology Center, Roswell Park Cancer Institute (RPCI) during the 48th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), November 5-9 in Philadelphia, PA.

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Kelvin P. Lee, MD, an outstanding national leader in medical oncology research, has been appointed Chair of the Department of Immunology and Vice Chair of the Department of Medicine at Roswell Park Cancer Institute (RPCI).

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Alex A. Adjei, MD, PhD, has been appointed Senior Vice President of Clinical Research and Chair of the Department of Medicine at Roswell Park Cancer Institute (RPCI).

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With less than five percent of all cancer patients in the country participating in clinical research studies, Roswell Park Cancer Institute (RPCI) has unveiled a major initiative that promises to change that profile in New York State. An anonymous $2 million gift will establish a dedicated Clinical Research Center at Roswell Park.

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Researchers at Roswell Park Cancer Institute are conducting a comprehensive study to determine factors affecting quality of life and risk of recurrence in women treated for breast cancer.

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Researchers at Roswell Park Cancer Institute and the University at Buffalo are using a new approach to detecting ovarian cancer early, when it is most curable.

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Researchers at Roswell Park Cancer Institute are analyzing vitamin D in prostate cancer prevention and treatment in the laboratory and the clinic.

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Susan McCann, PhD, will discuss the findings of her research in an oral presentation, "Dietary Lignan Intakes and Risk of Breast Cancer by Tumor Estrogen Receptor Status," at the 2006 annual meeting of the American Association for Cancer Research (AACR), Washington, DC.

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A diet with higher intakes of milk and tea may lower women's risk of developing acute myeloid leukemia (AML), according to scientists from the laboratory of Susan McCann, PhD, Division of Cancer Prevention & Population Sciences, Roswell Park Cancer Institute.

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Changing the size and surface charge of nanodevices significantly alters the way the nanodevices are taken up by organs and tissues in the body. This should allow for better targeting of treatments, according to scientists from the laboratory of Mohamed Khan, MD, PhD, and Lajos Balogh, PhD.

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A new drug may boost the effectiveness of a widely used treatment for patients with non-Hodgkin lymphoma (NHL), while simultaneously overcoming drug resistance in those patients. That conclusion is based on a study conducted by scientists from the laboratory of Myron Czuczman, MD, Department of Medicine, Roswell Park Cancer Institute.

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Researchers at Roswell Park Cancer Institute (RPCI) have discovered a gene that shows promise in halting the spread of cancer cells. Labeled SSeCKS/Gravin/AKAP12, the gene was discovered by Roswell Park researcher Irwin Gelman, PhD, vice chair of the Department of Cancer Genetics at RPCI, and colleagues in his lab.

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Scientists from the Department of Medicine, Roswell Park Cancer Institute, presented preliminary laboratory and clinical results of new therapies for hematologic cancers earlier this month at the 47th Annual Meeting of the American Society of Hematology, Atlanta, GA.

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The Gilda Radner Familial Ovarian Cancer Registry, established in 1981 to track families who have included at least two first degree relatives diagnosed with ovarian cancer, is celebrating its 25th anniversary.

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This release offers an overview of skin cancer, how it develops and methods to treat it, including a non-surgical alternative called Photodynamic Therapy.

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An oral vaccine administered in genetically engineered potatoes shows promise against the Hepatitis B Virus (HBV). The vaccine, which consists of only one protein from the virus, may be safer than other oral vaccines that use weakened living viruses.

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Results of a study support taking a revised view of prostate cancer and how best to treat it. Almost all advanced prostate cancer responds well at first to androgen deprivation therapy but the cancer recurs with a poor prognosis. This study suggests that these cases might need to be managed in a different way.

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Roswell Park Cancer Institute (RPCI) will host the 7th annual meeting of the Regional Cancer Center Consortium for the Biological Therapy of Cancer, February 26-28, in the Research Studies Center, RPCI, Elm & Carlton Streets, Buffalo, NY.

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A new study suggests that surgeons are routinely performing an investigational procedure called sentinel node biopsy on women with early-stage breast cancer, which, the investigators say, may be affecting the generalizability of ongoing trials of the procedure.

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Since January 2003, 36 faculty members of Roswell Park Cancer Institute (RPCI) have competed successfully for 43 grants which have a total value of $40.9 million and a first year value of $11.2 million. These grants include two prestigious program project grants awarded by the National Cancer Institute.

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African-American men are known to be at greater risk for developing and dying from prostate cancer. Racial differences in the androgenic stimulation of the prostate could be the reason prostate cancer occurs at a younger age and progresses more rapidly in African than Caucasian Americans.

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Roswell Park Cancer Institute announced this week that the FDA has approved PHOTOFRIN photodynamic therapy in the treatment of high-grade dysplasia associated with Barrett's esophagus.

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New, more effective follow-up treatments are needed to manage patients after surgery for pancreatic cancer because only a small percentage of these patients benefit from the current "standard" adjuvant therapy -- chemoradiation.

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Conjugated linoleic acid (CLA) decreases blood vessel formation --slowing tumor growth -- according to the results of a Roswell Park Cancer Institute study.

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A surprising number of variations exist in the way physicians diagnose and treat mammogram-detected breast cancer, according to a study. Researchers from Roswell Park Cancer Institute (RPCI) and Independent Health examined claims data to determine if practice volume impacted breast cancer outcomes.

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Roswell Park Cancer Institute has initiated two Phase II clinical trials to evaluate the safety and effectiveness of photodynamic therapy using a newly-developed topical photosensitizing cream, aminolevulinic acid (ALA), for the treatment of various types of skin cancer and actinic keratosis, a precancerous condition.

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The Buffalo Niagara Prostate Cancer Consortium, located at Roswell Park Cancer Institute, is recognized as a national model for patient care by the National Comprehensive Cancer Network and the Oncology Roundtable of the Advisory Board Company. This innovative collaboration, a first in the nation, includes community urologists, academic institutions, patient support groups, insurance carriers and RPCI.

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Women who received radiation for a certain type of childhood cancer are at increased risk for complications during pregnancy, and therefore should be carefully assessed and closely monitored by their obstetricians.

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Roswell Park Cancer Institute (RPCI) is participating in a multi-center clinical trial to evaluate the benefits and side effects of isolated hyperthermic limb perfusion and melphalan, with or without tumor necrosis factor for patients with advanced melanoma in one of their limbs.

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A unique pilot initiative created at Roswell Park Cancer Institute was highlighted at the Sixth Annual Conference of the National Comprehensive Cancer Network: "Practice Guidelines and Outcomes Data in Oncology."

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Current treatment options may not be adequately meeting the needs of post-menopausal women who develop breast cancer. (JAMA, 2-21-01).

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The "not so good news" from a recent study conducted at Roswell Park Cancer Institute is that the incidence rates for two forms of common brain tumors - glioblastoma multiforme (GBM) and anaplastic astrocytoma - have increased in New York State between 1976 and 1995. The ìgood newsî is that the study may have revealed clues to the origins of GBM; the most common of these tumors. (Journal of Neurosurgery, 12-00)