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Researchers at UT Southwestern Medical Center studied outcomes for young women at a county hospital and found that while 97% of them accessed prenatal care, those with greater social needs were associated with adverse outcomes both during pregnancy and during the early weeks of their babies’ lives. The differences persisted even after adjusting for age, race, and body mass index.

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Combining two agents to block a parasitic worm’s life cycle boosted survival from a potentially deadly tropical disease to 85% in animal models, far better than either treatment alone, according to a proof-of-concept study led by UT Southwestern Medical Center pharmacologists.

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A subtle smile emerged on Dr. James Leidner’s face as he envisioned telling people of the unusual contribution he made to mankind’s mission to Mars.

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In a discovery that could one day benefit people suffering from traumatic brain injury, Alzheimer’s disease, and schizophrenia, UT Southwestern researchers have identified the characteristics of more than 100 memory-sensitive neurons that play a central role in how memories are recalled in the brain.

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Funded by a Specialized Program of Research Excellence (SPORE) award from the National Cancer Institute (NCI), the Kidney Cancer Program (KCP) at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center reports the largest and most diverse catalog of kidney cancer tumor models to date.

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The Harold C. Simmons Comprehensive Cancer Center has been awarded grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to increase minority participation in clinical trials, expand lung cancer screening, develop brain tumor drugs, and advance innovations in drug discovery and technology.

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A study involving UT Southwestern neurology researchers found lower-quality outcomes for Hispanic ischemic stroke patients who receive endovascular thrombectomies than for comparable white and Black patients.

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UT Southwestern and University of Washington researchers led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions. The study, published in Science, identified more than 100 probable protein complexes for the first time and provided structural models for more than 700 previously uncharacterized ones. Insights into the ways pairs or groups of proteins fit together to carry out cellular processes could lead to a wealth of new drug targets.

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Ground has been broken for construction of a new building that will catalyze a unique partnership between UT Southwestern Medical Center and UT Dallas, bringing their biomedical engineering programs together to foster innovative solutions for unmet medical needs.

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The outcome predictive models were developed in part using data from a large multi-center National Institute of Mental Health-funded study and published in the journal Biological Psychiatry. The findings provide strong evidence that the current trial-and-error approach used in clinical practice for the selection of the right antidepressant can be replaced with this new precision medicine approach.

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Blocking a molecule that draws sensory nerves into musculoskeletal injuries prevents heterotopic ossification (HO), a process in which bone abnormally grows in soft tissue during healing, UT Southwestern researchers reported in a study. The findings, published in Nature Communications, suggest that drugs currently being tested in clinical trials to inhibit this molecule for pain relief could also protect against this challenging condition.

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UT Southwestern Medical Center has been selected as a Rare Disease Center of Excellence – charter members of an elite network of 31 centers nationally to expand access, and advance care and research for rare disease patients in the United States.

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New findings by UT Southwestern researchers help better understand the how one of the most commonly mutated genetic drivers of cancer passes signals that cause the disease.

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UT Southwestern scientists may have identified a method of safely mimicking the weight-loss benefits of a plant compound that – despite its harmful side effects – hold critical answers to developing therapies for obesity.

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A study by UT Southwestern researchers finds that changing the biochemistry of parts of brain cells abolished the formation of amyloid beta plaques in a mouse model of Alzheimer’s disease. The finding, published in eLife, might eventually lead to treatments that prevent the memory-robbing condition in humans.

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UT Southwestern researchers have identified a new mechanism by which stress causes cells to stop dividing.

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Samuel Achilefu, Ph.D., the incoming Inaugural Chair of UT Southwestern Medical Center’s new Department of Biomedical Engineering, is among 100 members elected to the National Academy of Medicine (NAM) this year.

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A genome engineering technique developed at UT Southwestern Medical Center helped make the institution a research partner in a new $185 million National Institutes of Health (NIH) initiative to build on findings of the Human Genome Project.

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How cancers metastasize remains poorly understood. The process begins when cancer cells break off from a tumor and invade blood and lymphatic vessels, the body’s alleyways. But studying invasion - typically a microscopic process - is challenging.

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Oxygen-deprived newborns who undergo cooling therapy to protect their brains are at an elevated risk of seizures and brain damage during the rewarming period, which could be a precursor of disability or death, a new study by a team of researchers led by a UT Southwestern pediatrician suggests. The finding, published online in JAMA Neurology, could lead to better ways to protect these vulnerable patients during an often overlooked yet critical period of cooling – or hypothermia – therapy.

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Peter O’Donnell Jr., whose vision, legendary generosity, and cherished friendship graced UT Southwestern Medical Center for many decades, passed away Oct. 10 at the age of 97.

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A team of researchers at UT Southwestern Medical Center’s Touchstone Diabetes Center have successfully used CRISPR gene editing to turn fat cells normally used for storage into energy-burning cells.

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Specialized cells that conduct electricity to keep the heart beating have a previously unrecognized ability to regenerate in the days after birth, a new study in mice by UT Southwestern researchers suggests. The finding, published online in the Journal of Clinical Investigation, could eventually lead to treatments for heart rhythm disorders that avoid the need for invasive pacemakers or drugs by instead encouraging the heart to heal itself.

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Lu Sun, Ph.D., Assistant Professor of Molecular Biology at UT Southwestern, has been awarded $1.5 million from the National Institutes of Health (NIH) to study interactions between neurons and glial cells in the brain, which could provide insight into the causes of neurological disorders.

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Jian Zhou, Ph.D., Assistant Professor in UT Southwestern’s Lyda Hill Department of Bioinformatics, has been awarded $1.5 million from the National Institutes of Health (NIH) to use artificial intelligence to investigate the three-dimensional structure of DNA and its impact on health.

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Lorena Saelices Gomez, Ph.D., Assistant Professor of Biophysics and in the Center for Alzheimer’s and Neurodegenerative Diseases at UT Southwestern, has been awarded $1.5 million from the National Institutes of Health (NIH) to determine the structure of amyloids, key proteins that have been tied to diseases including Alzheimer’s and ATTR amyloidosis.

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A UT Southwestern research team has received the National Institutes of Health’s prestigious Transformative Research Award to further their study of zebra finches to investigate the genetic basis of vocal imitation abilities.

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An international panel of experts from four renowned diabetes research centers, including UT Southwestern Medical Center, has reviewed current literature and is recommending a pivotal change in treatment of Type 2 diabetes to focus on obesity first and glucose control second.

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Unvaccinated pregnant women are increasingly being hospitalized with COVID-19 during a nationwide surge of the Delta variant, according to research from UT Southwestern Medical Center.

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UT Southwestern stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration. Their results, which are published in Cell, show that this tracing is far from routine in the field and suggest that earlier studies reporting “striking” regeneration results must be reexamined.

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Researchers and data scientists at UT Southwestern Medical Center and MD Anderson Cancer Center have developed an artificial intelligence technique that can identify which cell surface peptides produced by cancer cells called neoantigens are recognized by the immune system.

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Two UT Southwestern Medical Center researchers – a biochemist and a molecular biologist – are among 33 distinguished scientists nationwide named Howard Hughes Medical Institute (HHMI) Investigators.

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A study led by UT Southwestern dermatologists suggests that a common inflammatory skin condition may stem from poorly regulated sex hormones. The finding, published this week in PNAS, could offer an unexpected new target to fight this condition.

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Immunologists and geneticists at UT Southwestern Medical Center have discovered how vitamin A enters immune cells in the intestines – findings that could offer insight to treat digestive diseases and perhaps help improve the efficacy of some vaccines.

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UT Southwestern Medical Center will lead the nation’s first study of suicide prevention for LGBTQ+ young adults – a group at higher risk for depression and suicide.

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Adenomyosis – an abnormal tissue growth into the muscular wall of the uterus that causes painful cramps and heavy or prolonged menstrual bleeding – is more common than generally appreciated, a review of the literature by gynecologists at UT Southwestern Medical Center revealed.

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A new study by UT Southwestern scientists indicates that an enzyme called protein phosphatase 2 (PP2A) appears to be a major driver of preeclampsia, a dangerous pregnancy complication characterized by the development of high blood pressure and excess protein in the urine. The finding, published in Circulation Research, could lead to new treatments for preeclampsia other than premature delivery, which is often the only option.

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The National Cancer Institute has renewed the Harold C. Simmons Comprehensive Cancer Center’s comprehensive designation, reaffirming its place among the country’s elite cancer institutes.

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UT Southwestern Medical Center was recognized as the top health care employer in Texas, one of the top 10 employers across all industries in the state, and among the nation’s Best-in-State employers nationally by Forbes/Statista.