Modulation of Temozolomide Dose Differentially Affects T cell Response to Immune Checkpoint Inhibition
A presentation at the 2019 American Association of Neurological Surgeons Annual Scientific Meeting
Article ID: 711288
Released: 15-Apr-2019 7:00 PM EDT
Source Newsroom: American Association of Neurological Surgeons (AANS)
Newswise — SAN DIEGO (April 15, 2019) — Winner of the Preuss Research Award, Maryam Rahman, MD, FAANS, presented her research, Modulation of Temozolomide Dose Differentially Affects T cell Response to Immune Checkpoint Inhibition, during the 2019 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting.
Temozolomide has been shown to have both synergistic and negative effects on immune response to different immunotherapy treatment platforms. Researchers aimed to determine the immune modulatory effects of temozolomide that would impact response to immune checkpoint inhibition in the treatment of experimental glioblastoma (GBM).
The study found that the peripheral and intratumoral immune microenvironments are distinctively affected by dose modulation of temozolomide impacting response to immune checkpoint inhibition in GBM. These results demonstrate the importance of thoughtfully modulating host immunity with chemotherapy, when combining with immunotherapy.
Author Block: Maryam Rahman, MD, FAANS (Gainesville, Fla.); Aida Karachi, DVM; Changlin Yang, MD, PhD; Farhad Dastmalchi, DVM; Elias Sayour, MD, PhD; Jianping Huang, MD, PhD; Duane Mitchell, MD, PhD
Disclosure: The author reported no conflicts of interest.
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Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 11,500 members worldwide. The AANS promotes the highest quality of patient care and advances the specialty of neurological surgery. Fellows of the AANS are board-certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons of Canada or the Mexican Council of Neurological Surgery, A.C. Neurosurgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the spinal column, spinal cord, brain, nervous system and peripheral nerves.
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