Newswise — LA JOLLA, Calif., April 3, 2014 — Sanford-Burnham Medical Research Institute will present a wide range of new research data at the annual American Association for Cancer Research Meeting in San Diego starting Saturday, April 5, at the San Diego Convention Center. The presentations will cover a variety of topics including breast, melanoma, and prostate cancer, as well as novel methods of delivering drugs to tumors.

If you are interested in interviewing a Sanford-Burnham researcher, please contact Susan Gammon at [email protected]

Highlights of Sanford-Burnham’s data to be presented include:

Oral Presentation

Melanoma• microRNA-211 modulates energy metabolism in human melanoma cells by destabilizing HIF1-alpha and down-regulating PDK4o Ranjan Joseph Perera, Ph.D., presentation # 978, Sunday, April 6, 3:15 p.m.- 5:15p.m., Room 31

Poster Presentations

Brain Cancer• Structural variants shuffle chromatin to activate GFI1 family oncogenes in medulloblastomao Catherine Lee, Ph.D., presentation # LB-203, Tuesday, April 8, 8 a.m.-12 p.m. Hall A-E, Poster Section 40

Breast Cancer• RNF5 mediates ER stress-induced degradation of SLC1A5 in breast cancero Young Joo Jeon, Ph.D., presentation # 2440, Monday, April 7, 1 p.m.-5 p.m. Hall A-E, Poster Section 23• Targeting premalignant lesions for early breast cancer detection and interventiono Aman P. Mann, Ph.D., presentation # 3258, Tuesday, April 8, 8 a.m.-12 p.m. Hall A-E, Poster Section 12

Cancer Metastasis• Membrane pseudokinase PTK7 regulates metastasiso Vladislav Golubkov, Ph.D., presentation # 3009, Tuesday, April 8, 8 a.m.-12 p.m. Hall A-E, Poster Section 3

Drug Delivery Strategies• A tumor-specific tissue-penetrating peptide inhibits metastasiso Kazuki N. Sugahara, Ph.D., presentation # LB-102, Monday, April 7, 8 a.m.-12 p.m. Hall A-E, Poster Section 42• Urokinase plasminogen activator-dependent tumor-penetrating peptideo Tambet Teesalu, Ph.D., presentation # 4504, Tuesday, April 8, 1 p.m.-5 p.m. Hall A-E, Poster Section 29• Targeted therapies and nanoparticle strategies for selective drug deliveryo Hong-Bo Pang, Ph.D., presentation # 5406, Wednesday, April 9, 8 a.m.-12 p.m. Hall A-E, Poster Section 28

Epigenetics• Mycoplasma DNA methyltransferase induces aberrant global hypermethylation and activate cancer-specific genes in human cellso Andrei Chernov, Ph.D., presentation # 2312, Monday, April 7, 1 p.m.-5 p.m. Hall A-E, Poster Section 18

Melanoma• PDK1 in melanoma development and metastasiso Marzia Scortegagna, Ph.D., presentation # 59, Sunday, April 6, 1 p.m.-5 p.m. Hall A-E, Poster Section 3• Tks adaptor proteins and invadopodia formation in the growth and metastasis of melanomao Shinji Iizuka, Ph.D., presentation # 3155, Tuesday, April 8, 8 a.m.-12 p.m. Hall A-E, Poster Section 8• Inhibition of melanoma growth by small molecules that attenuate P13K/PDK1 signaling and promote ATF2 mitochondrial localizationo Giuseppina Claps, M.S., presentation # 4520, Tuesday, April 8, 1 p.m.-5 p.m. Hall A-E, Poster Section 30• Interfering with interferon: An axis of ATF-2mediated chemoresistanceo Eric Lau, Ph.D., presentation # 4901, Tuesday, April 8, 1 p.m.-5 p.m. Hall A-E, Poster Section 9

Prostate Cancer• Small molecule SBI-601 inhibits Siah1/2 ubiquitin ligases, attenuates HIF1-alpha expression and growth of melanoma and prostate cancer cellso Yongmei Feng, Ph.D., presentation # 1795, Monday, April 7, 8 a.m.-12 p.m. Hall A-E, Poster Section 33• The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen-receptor signalingo Ricardo G. Correa, Ph.D., presentation # LB-74, Monday, April 7, 8 a.m.-12 p.m. Hall A-E, Poster Section 41

Join the conversation on Facebook and Twitter using #AACR14.

Sanford-Burnham’s NCI-designated Cancer Research CenterThe Cancer Center is on a mission to discover new revelations about the molecular mechanisms of cancer, with state-of-the-art drug-discovery capabilities, and a team of scientists who are relentless in pursing advances to improve the lives of cancer patients. The Cancer Center is one of seven NCI-designated basic-research cancer centers in the nation, and global leader in turning scientific discoveries into new therapeutic approaches.

About Sanford-Burnham Medical Research InstituteSanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration and stem cells, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is recognized for its National Cancer Institute-designated Cancer Center and expertise in drug discovery technologies. Sanford-Burnham is a nonprofit, independent institute that employs 1,200 scientists and staff in San Diego (La Jolla), Calif., and Orlando (Lake Nona), Fla. For more information, visit us at sanfordburnham.org.

MEDIA CONTACT
Register for reporter access to contact details
CITATIONS

AACR Annual Meeting 2014