Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS)

Clinical Characteristics and Outcomes in Patients with Coronavirus Disease 2019 and Multiple Sclerosis

Research Alert

Newswise — Background: Risk factors associated with the severity of COVID-19 in patients with multiple sclerosis (MS) begin to be identified from several cohort studies. Disease modifying therapies (DMTs) may modify the risk of developing a severe COVID-19 infection, beside identified risk factors such as age and comorbidities.

Objectives: The objective was to describe the clinical characteristics and outcomes in patients with COVID-19 and to identify the factors associated with COVID-19 severity.

Methods: This multicenter, retrospective, observational cohort study (COVISEP registry, NCT04355611) included patients with MS presenting with a confirmed or highly suspected diagnosis of COVID-19 between March 1, 2020 and July 14, 2020. The main outcome was COVID-19 severity assessed on a 7-point ordinal scale (ranging from 1: not hospitalized, no limitations on activities, to 7: death; cutoff at 3: hospitalized, not requiring supplemental oxygen). We collected demographics, neurological history, Expanded Disability Severity Score (EDSS), comorbidities, COVID-19 characteristics and outcome. Univariate and multivariate logistic regression models were used to estimate the influence of collected variables on COVID-19 outcome.

Results: A total of 405 patients (mean age: 44.7 years, female/male: 293/112, mean disease duration: 13.4 years) were analyzed. Seventy-eight patients (19.3%) had a COVID-19 severity score ≥ 3, and 12 patients (3.0%) died from COVID-19. Median EDSS was 2.0 (range: 0-9.5), 326 patients (80.5%) were on DMT. There was a higher proportion of patients with COVID-19 severity score ≥ 3 among patients with no DMT relative to patients on DMTs (39.2% versus 14.4%, p<0.001). Multivariate logistic regression models determined that age (OR for 10 years: 1.8, 95% CI: 1.4-2.4), EDSS (OR for EDSS ≥ 6: 4.5, 95% CI: 2.0-10.0) were independent risk factors for COVID-19 severity score ≥ 3 (hospitalization or higher severity) while immunomodulatory treatment (interferon or glatiramer acetate) was associated with lower risk of COVID-19 severity score ≥ 3 (OR: 0.2, 95% CI: 0.05-0.8). EDSS was associated with the highest variability of COVID-19 severe outcome (R2= 0.18), followed by age (R2= 0.06) and immunomodulatory treatment (R2= 0.02).

Conclusions: EDSS and age were independent risk factors of severe COVID-19, while exposure to immunomodulatory DMTs (interferon and glatiramer acetate) were independently associated with lower COVID-19 severity. We did not find an association between other DMTs exposure (including immunosuppressive therapies) and COVID-19 severity. The identification of these risk factors should provide the rationale for an individual strategy regarding clinical management of MS patients during the COVID-19 pandemic.

Presenter: Celine Louapre, Pitié-Salpêtrière hospital, APHP, Neurology

Filters close

Showing results

110 of 6074
Newswise: Connect Chicago Initiative Expands Community COVID-19 Testing
Released: 27-Jul-2021 4:45 PM EDT
Connect Chicago Initiative Expands Community COVID-19 Testing
Rush University Medical Center

As COVID-19 cases rise in the U.S., Connect Chicago — new initiative between the Chicago Department of Public Health, Rush University Medical Center, and Esperanza Health Centers — is aiming to redouble testing efforts in Chicago communities that need it most.

Newswise: California State University to Implement COVID-19 Vaccination Requirement for Fall 2021 Term
Released: 27-Jul-2021 1:35 PM EDT
California State University to Implement COVID-19 Vaccination Requirement for Fall 2021 Term
California State University (CSU) Chancellor's Office

California State University to Implement COVID-19 Vaccination Requirement for Fall 2021 Term

Released: 27-Jul-2021 12:55 PM EDT
Behind the COVID-19 Diagnostic for Testing Hundreds of People at a Time
The Fannie and John Hertz Foundation

Hertz Fellow Cameron Myhrvold and colleagues are advancing research that started long before the pandemic.

Released: 27-Jul-2021 12:35 PM EDT
T cell response not critical for immune memory to SARS-CoV-2 or recovery from COVID-19
American Society for Microbiology (ASM)

New research conducted in monkeys reveals that T cells are not critical for the recovery of primates from acute COVID-19 infections.

Released: 27-Jul-2021 11:45 AM EDT
mRNA Vaccinations vs COVID-19 Risk in Teens – Vaccinations are Safer
Case Western Reserve University

Case Western Reserve University researchers have demonstrated that the risk for myocarditis/pericarditis (heart inflammation) among male teens (12-17) diagnosed with COVID-19 is nearly 6 times higher than their combined risk following first and second doses of an mRNA COVID-19 vaccination. The risk for myocarditis/pericarditis among girls (ages 12-17) is 21 times greater from COVID-19 than from vaccines.

Released: 27-Jul-2021 9:45 AM EDT
Twitter Study Tracks Early Days of COVID-19 Pandemic in U.S.
Binghamton University, State University of New York

Researchers at Binghamton University, State University of New York studied Twitter communications to understand the societal impact of COVID-19 in the United States during the early days of the pandemic.

Released: 27-Jul-2021 9:45 AM EDT
A First Report of COVID-19 Orbital Involvement Is Reported in the Journal of Craniofacial Surgery
Wolters Kluwer Health: Lippincott

A severe skin infection in the orbital area (around the eye) may represent an unusual complication of COVID-19, according to a patient report published in The Journal of Craniofacial Surgery. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Newswise: “Baiya Vaccine” from Chula — a Testament of Thai Mastery — Coming this September
Released: 27-Jul-2021 8:55 AM EDT
“Baiya Vaccine” from Chula — a Testament of Thai Mastery — Coming this September
Chulalongkorn University

Chula Pharmacy prepares to test “Baiya Vaccine” a Thai vaccine against COVID–19 by “Baiya Phytofarm“, a Chula startup. The vaccines have been produced at the first plant in Asia that manufactures plant–based vaccines for humans. Clinical trials with volunteers and the research for the second–generation vaccine to fight the virus variants are to commence in September 2021.

Showing results

110 of 6074