American Thoracic Society (ATS)

Clinicians Treating COVID-19 Say Don’t Rush to Try Novel Therapies Without Proof of Benefit

Newswise — April 27, 2020 – Intensivists caution against the use of premature novel therapies in lieu of traditional critical care principles in patients with COVID-19 in a recent correspondence letter in the American Journal of Respiratory Cell and Molecular Biology.

In “A Call for Rational Intensive Care in the Era of COVID-19”,  Benjamin Singer, MD, Assistant Professor of Medicine and Biochemistry & Molecular Genetics, Division of Pulmonary and Critical Care Medicine, Department of Medicine, at Northwestern University Feinberg School of Medicine, and co-authors write that “the intensive care unit is already optimized for the care of COVID-19 patients and that departures from standard of care require evidence…”

The COVID-19 pandemic is unprecedented, resulting in a surge of critically ill patients that have tested the resources of medical centers around the country. The overwhelming patient demand and dwindling resources combined to trigger a cascade of emotions, stress, and fatigue. As hospital staff mobilize to meet the growing demand of COVID-19 patients, some clinicians are making note of a pattern that has emerged where proven interventions are neglected or even rejected.

Dr. Singer, who is also associate editor of the American Journal of Respiratory Cell and Molecular Biology, argues that this is not the time to abandon reason. Instead, he calls for “a rational approach to translating science to the bedside as we care for patients with severe COVID-19. We want to come out of the COVID-19 pandemic knowing what works and what doesn’t work for severe viral pneumonia patients.”

He added that physicians continuously learn from their patients by making observations and so far what they’ve learned is that the most effective treatment for COVID-19 patients is supportive therapy. Until there are clinical trials that offer clear direction on a different treatment approach, state-of-the-art supportive care is the best option.

“Off-label and off-study use of novel or repurposed therapeutics prevents potential benefits or harms from being clearly defined and puts some of our most vulnerable people at risk,” cautioned Dr. Singer.

 

Share via Twitter:

Clinicians treating #COVID-19 say don’t rush to try novel therapies without proof of benefit. @atscommunity @AJRCMB @bsinger007 @NMPulmCritCare

 

About the American Journal of Respiratory Cell and Molecular Biology (AJRCMB): The American Journal of Respiratory Cell and Molecular Biology (AJRCMB) is a peer-reviewed journal published by the American Thoracic Society. AJRCMB publishes the most significant and original observations in the area of respiratory and lung cell biology, including cellular, biochemical, molecular, developmental, genetic, and immunologic studies in health and in acute and chronic disorders related to the respiratory system and sleep. The journal’s Impact Factor is 4.34.

Editor: Paul T. Schumacker, Ph.D. professor of Neonatology Research in the Department of Pediatrics at Northwestern University Feinberg School of Medicine and the Ann & Robert H. Lurie Children’s Hospital, with joint appointments in the Departments of Medicine (Pulmonary & Critical Care), Cellular & Molecular Biology, and the Northwestern University Comprehensive Cancer Center.

 

 

About the American Thoracic Society

Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society’s more than 16,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy. The ATS publishes four journals, the American Journal of Respiratory and Critical Care Medicine, the American Journal of Respiratory Cell and Molecular Biology,  the Annals of the American Thoracic Society and ATS Scholar.

 

 

SEE ORIGINAL STUDY




Filters close

Showing results

110 of 3817
Released: 30-Oct-2020 6:35 PM EDT
UCLA Health infectious disease experts tout critical role mask wearing plays in limiting spread of COVID-19
University of California, Los Angeles (UCLA), Health Sciences

With thousands of new cases logged daily and a vaccine to fight COVID-19 still in development, UCLA Health infectious disease experts are encouraging people to continue to wear masks as the best method of protecting against virus transmission.

Released: 30-Oct-2020 5:35 PM EDT
Surgeon General expects COVID-19 vaccine to be available by year’s end
University of California, Los Angeles (UCLA), Health Sciences

In a wide-ranging talk with UCLA Health physicians, Wednesday, Oct. 28, United States Surgeon General Jerome Adams, MD, MPH, addressed the politicization of the pandemic and the means of containing the spread of COVID-19. He also offered hope that a vaccine for the virus will be available by year’s end.

Released: 30-Oct-2020 4:15 PM EDT
Study shows myocarditis linked to COVID-19 not as common as believed
Louisiana State University Health Sciences Center - New Orleans

A study conducted by Richard Vander Heide, MD, PhD, Professor and Director of Pathology Research at LSU Health New Orleans School of Medicine, and Marc Halushka, MD, PhD, Professor of Pathology at Johns Hopkins University School of Medicine, suggests myocarditis caused by COVID-19 may be a relatively rare occurrence.

access_time Embargo lifts in 2 days
Embargo will expire: 3-Nov-2020 11:00 AM EST Released to reporters: 30-Oct-2020 3:00 PM EDT

A reporter's PressPass is required to access this story until the embargo expires on 3-Nov-2020 11:00 AM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Newswise: 247373_web.jpg
Released: 30-Oct-2020 2:30 PM EDT
Researcher develops app to reach Black community with COVID-19 information
University of Cincinnati

A University of Cincinnati cardiologist is partnering with researchers in St. Louis and rural Georgia to develop a smartphone app that will deliver COVID-19 information and education that is targeted toward Black communities.

Newswise: 247467_web.jpg
Released: 30-Oct-2020 1:55 PM EDT
SARS-CoV-2 might attack red marrow and block new erythrocytes formation
Far Eastern Federal University

Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging. According to researchers, the virus might attack red marrow, thus being detrimental not only for erythrocytes in the bloodstream but also for the process of the formation of the new ones.

Released: 30-Oct-2020 12:40 PM EDT
Government of Canada awards $2.5M to McMaster University to support the COVID-19 border study with McMaster HealthLabs
McMaster University

McMaster University has been awarded $2.5 million from the Government of Canada to support the McMaster HealthLabs (MHL) Canadian International COVID-19 Surveillance Border Study at Toronto Pearson International Airport, being run in partnership with Air Canada and the Greater Toronto Airports Authority (GTAA).

Released: 30-Oct-2020 12:00 PM EDT
5 Big Questions on Health Care and COVID-19
University of Virginia Darden School of Business

The coronavirus pandemic has once again thrust the unusual state of American health care into the spotlight. With a presidential election that could have a dramatic impact on the state of health care for millions on 3 November, Professor Vivian Riefberg considers the state of the industry.

Newswise: Infection by Confection: COVID-19 and the Risk of Trick-or-Treating
Released: 30-Oct-2020 11:05 AM EDT
Infection by Confection: COVID-19 and the Risk of Trick-or-Treating
University of California San Diego Health

Researchers determined that COVID-19 transmission risk via Halloween candies is low, even when they are handled by infected people, but handwashing and disinfecting collected sweets reduces risk even further.

Newswise:Video Embedded third-spike-in-covid-19-cases-plus-the-vaccine-trials-live-expert-panel-for-october-29-3pm-edt
VIDEO
Released: 30-Oct-2020 9:40 AM EDT
TRANSCRIPT AND VIDEO AVAILABLE: "Third spike" in COVID-19 cases, plus the vaccine trials: Live Expert Panel for October 29
Newswise

"Third spike" in COVID-19 cases, plus the vaccine trials: Live Expert Panel for October 29, 3PM EDT


Showing results

110 of 3817

close
1.46624