Fred Hutchinson Cancer Research Center

Tip Sheet: Cancer health disparities, app to stop smoking, diversity in COVID-19 vaccine trials — and more

Summaries of recent Fred Hutch research findings and other news, plus resources for October's Breast Cancer Awareness Month

Newswise — SEATTLE – Oct. 1, 2020 – Below are summaries of recent Fred Hutch research findings and other news with links for additional background and media contacts.

And if you’re looking for sources for October’s Breast Cancer Awareness Month, please see our breast cancer page for a list of projects, experts and the latest breast cancer news.

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Health disparities

How to achieve equity in cancer care, research and beyond Two national reports by the American Association for Cancer Research illustrate both the progress — and the lack thereof — in easing the burden of cancer on the American population. Co-author Dr. Christopher Li discussed the 10th annual Cancer Progress Report in an AACR Congressional briefing. The report includes new drug approvals, genomic advances and progress in liquid biopsies. In addition, the AACR published its inaugural Cancer Disparities Progress Report, a baseline document on the inequities in cancer in the U.S.

We still have so much work to do’ Longtime health disparities researcher Kathy Briant discussed the inaugural Cancer Disparities Progress Report from AACR. She put it into context with Fred Hutch/University of Washington Cancer Consortium research in areas where cancer health disparities exist — including preventable risk factors and cancer screening/early detection.

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COVID-19 vaccines

CoVPN team leads campaign to ensure diversity in COVID-19 vaccine trials Fred Hutch-based experts have engaged in extensive media efforts to drive conversations and awareness about the importance of inclusive participation in COVID-19 vaccine trials. The effort is through the COVID-19 Prevention Network, or CoVPN, which is coordinating Phase 3 COVID-19 vaccine trials, with its operations center headquartered at Fred Hutch.

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Clinical oncology

Immunotherapy trial in advanced bladder and other urinary tract cancers shows ‘exciting’ results In a recently published large randomized clinical trial, researchers found that patients with advanced urothelial carcinoma survived longer when given the immunotherapy drug avelumab following chemotherapy. They reported preliminary trial findings at the American Society of Clinical Oncology meeting in early summer.

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Prevention

Fred Hutch-led clinical trial shows new smartphone app helps smokers quit Scientists at Fred Hutch believe they’ve found a better of use of mobile technology to help adult cigarette smokers quit. In a large clinical trial published in JAMA Internal Medicine, a team led by Dr. Jonathan Bricker found that the new smartphone app iCanQuit was one-and-a-half times more effective than the National Cancer Institute’s QuitGuide.

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Basic sciences

Fruit flies add more weight to theory that individual bodies have set points Researchers discovered that a neural circuit responsible for sensing energy stores is designed to reset itself. The idea that we may have weight set points — a weight that an individual’s body tries to maintain even as food intake and energy expenditure fluctuate — has been floated by obesity researchers to help explain why weight loss can be such a challenge.

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COVID-19’s impact on science

We profiled how Fred Hutch researchers have shifted their science during the pandemic.

·         How COVID-19 has opened science: An urgent search for answers promotes a faster, freer exchange of ideas.

·         Public health's pandemic pivot: With disease modeling, virtual events and a renewed focus on anti-racism, Fred Hutch population scientists adapt their work to COVID-19.

·         Stalled science, missed mates and virtual everything: Torn between science and safety concerns, young scientists navigate a new normal as they try to launch their careers.

·         Everything we've been training for is happening now’: How early career virologists dropped everything to seize the opportunity, and face the challenges, of studying COVID-19.

Watch: How COVID-19 changed science Dr. Tom Lynch, Fred Hutch president and director, talks with Drs. Ruth Etzioni (a biostatistician focused on cancer screening and early detection), Jesse Bloom (an evolutionary biologist and expert in viruses) and Neel Dey (a physician-scientist and expert in colorectal cancer and the microbiome) about how their work has shifted, including new projects with COVID-19.

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Other notable news

Fred Hutch Evergreen Fund awards six grants for projects with commercial potential

New award to develop targeted treatments for pancreatic cancer

New Brave Fellowship powers Dr. Alyssa Webster’s race for new leukemia cures

 

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Newswise: Long-Term Impacts of COVID-19: Your Mental Health
Released: 25-Nov-2020 2:15 PM EST
Long-Term Impacts of COVID-19: Your Mental Health
Cedars-Sinai

The COVID-19 pandemic has shaped more than half a year of our lives, canceling plans, upending livelihoods and causing feelings of grief, stress and anxiety. And Cedars-Sinai mental health experts say the pandemic could be shaping our mental health well into the future.

Released: 25-Nov-2020 12:45 PM EST
SARS-CoV-2 mutations do not appear to increase transmissibility
University College London

None of the mutations currently documented in the SARS-CoV-2 virus appear to increase its transmissibility in humans, according to a study led by UCL researchers.

Newswise: COVID-19 vaccine candidate tested preclinically at UAB nears first clinical test in people
Released: 25-Nov-2020 11:05 AM EST
COVID-19 vaccine candidate tested preclinically at UAB nears first clinical test in people
University of Alabama at Birmingham

Maryland-based Altimmune Inc., a clinical stage biopharmaceutical company, has submitted an Investigational New Drug, or IND, application to the United States Food and Drug Administration to commence a Phase 1 clinical study of its single-dose intranasal COVID-19 vaccine candidate, AdCOVID.

Released: 25-Nov-2020 11:05 AM EST
BIDMC researchers reveal how genetic variations are linked to COVID-19 disease severity
Beth Israel Lahey Health

New research BIDMC-led sheds light on the genetic risk factors that make individuals more or less susceptible to severe COVID-19.

Newswise: blog-pandemic-scenario-planning-lg-feature2.jpg
Released: 25-Nov-2020 11:05 AM EST
Pandemic Ups Game on Scenario Planning in The Arts
Wallace Foundation

Researcher/Author of new toolkit and report seeks to help arts and culture organizations add scenario planning to their strategic toolbox

Released: 25-Nov-2020 10:30 AM EST
Young people's anxiety levels doubled during first COVID-19 lockdown, says study
University of Bristol

The number of young people with anxiety doubled from 13 per cent to 24 per cent, during the early stages of the COVID-19 pandemic and lockdown 1, according to new research from the University of Bristol.

Newswise: 249837_web.jpg
Released: 25-Nov-2020 10:20 AM EST
Tracking COVID-19 trends in hard-hit states
Louisiana State University

Currently, there are over 10 million confirmed cases and more than 240,000 casualties attributed to COVID-19 in the U.S.

Released: 25-Nov-2020 9:55 AM EST
More Health Systems Join National #MaskUp Campaign
Cleveland Clinic

Many more health systems are joining the national #MaskUp campaign encouraging Americans to stop the spread of COVID-19 by following safety guidelines. Over just a few days, another 19 health systems with hundreds of hospitals united with 100 health systems nationwide with hospitals numbering in the thousands. The public service campaign is critical to the health and well-being of all Americans. It is a plea from healthcare professionals everywhere: wear a mask and follow other precautions to save lives and help get our country back on its feet.

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Released: 25-Nov-2020 7:35 AM EST
Warwick scientists design model to predict cellular drug targets against Covid-19
University of Warwick

The covid-19 virus, like all viruses relies on their host for reproduction

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Embargo will expire: 30-Nov-2020 10:00 AM EST Released to reporters: 24-Nov-2020 5:35 PM EST

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