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Scientists Identified a Cellular Network That “Short Circuits” the Antitumor Effect of Novel Immunotherapy

Wistar researchers discovered a novel form of crosstalk among tumor cells and other cell types in the tumor microenvironment, elucidating the mechanism of action of an immunotherapeutic strategy that inhibits tumor-associated macrophages (TAMs) and...
10-Nov-2017 2:05 PM EST Add to Favorites

The Wistar Institute Awarded More Than $16.5M in Grants to Fund Cancer & Infectious Disease Research and Training

Wistar scientists have secured more than $16.5 million in funding throughout the summer and early fall of 2017.
6-Nov-2017 11:05 AM EST Add to Favorites

Wistar Expands Collaboration & Signs Exclusive License Agreement with Man’s Best Friend Therapeutics to Develop Novel Veterinary Vaccine Technology

The collaboration will further advance a canine melanoma vaccine and other vaccines for cancer and infectious diseases in animals
2-Nov-2017 9:00 AM EDT Add to Favorites

Genome Architecture Caught in Motion

Researchers at The Wistar Institute have uncovered new aspects of the three-dimensional organization of the genome, specifically how the genetic material is compacted and de-compacted in a timely fashion during the different phases of the cell cycle.
9-Oct-2017 11:05 AM EDT Add to Favorites

NIH Selects Wistar Scientist Kavitha Sarma, Ph.D., for New Innovator Award

The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, announces Kavitha Sarma, Ph.D., assistant professor in Wistar’s Gene Expression and Regulation Program, has been...
5-Oct-2017 1:05 PM EDT Add to Favorites

Characterization of a Slowly Proliferating Population of Melanoma Cells with High Metastatic Properties

A study conducted at The Wistar Institute has led to the identification of a slowly proliferating and highly invasive melanoma cell subpopulation, characterized by production of a protein associated with invasive behavior.
20-Sep-2017 11:05 AM EDT Add to Favorites

Tumor-infiltrating B Lymphocytes Promote Melanoma Progression and Resistance to Therapy

In a multi-institutional collaborative study, scientists at The Wistar Institute and the Medical University of Vienna, Austria, have identified the role of tumor-infiltrating or tumor-associated B-cells (“TABs”) in melanoma progression and...
19-Sep-2017 12:05 PM EDT Add to Favorites

A Newly Identified Mitochondrial Metastasis Suppressor Pathway Controls Metabolic Reprogramming of Tumor Cells

A novel mitochondrial variant of the protein Syntaphilin, or SNPH, which orchestrates the choice between cancer cell proliferation and metastasis in response to oxygen and nutrient shortage in the tumor microenvironment, has been identified by...
8-Sep-2017 1:05 PM EDT Add to Favorites

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