New Insights Into the Control of Inflammation

Wistar scientists discovered that EGR1 inhibits expression of pro-inflammatory genes in macrophages. The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many...
13-Jan-2021 2:10 PM EST Add to Favorites

Wistar Researchers Develop New Humanized Mouse Model That Provides Insight Into Immunotherapy Resistance

Wistar scientists have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells.
12-Jan-2021 8:45 AM EST Add to Favorites

Wistar Scientists Discover Link Between a Genetic Driver of Ovarian Cancer and Metabolism, Opening the Way for New Therapeutic Strategies

Wistar scientists found mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism. Researchers also showed that pharmacologic inhibition of...
11-Jan-2021 12:35 PM EST Add to Favorites

Wistar Scientists Target an Alternative Fuel Source of Cancer Cells as a Therapeutic Approach for Breast Cancer

Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in conditions of low nutrient and oxygen availability. This molecule caused...
7-Jan-2021 10:15 AM EST Add to Favorites

DARPA and JPEO-CBRND Award $37.6M to The Wistar Institute and Collaborators at INOVIO, AstraZeneca, Penn, & Indiana University to Develop Innovative COVID-19 Treatment

A team of scientists from The Wistar Institute, INOVIO, AstraZeneca, the Perelman School of Medicine at the University of Pennsylvania, and Indiana University has received a $37.6 million award over two years from the Defense Advanced Research...
15-Dec-2020 8:25 AM EST Add to Favorites

Wistar Creates a New Synthetic DNA Vaccine Against Powassan Virus

Wistar scientists have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein.
30-Oct-2020 11:55 AM EDT Add to Favorites

Advancement of Anticancer Compounds for B Cell Cancer Therapy Targeting a Cellular Stress Response Mechanism

Researchers at The Wistar Institute and collaborators from the University of Notre Dame are developing anticancer compounds targeting a pathway of the endoplasmic reticulum (ER) stress response implicated in the development of multiple myeloma (MM),...
13-Oct-2020 10:40 AM EDT Add to Favorites

New Mechanism of Cell Survival in Chronic Lymphocytic Leukemia

Researchers at The Wistar Institute unraveled a mechanism employed by chronic lymphocytic leukemia (CLL) cells for their survival.
30-Sep-2020 10:35 AM EDT Add to Favorites

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