Maintaining genomic integrity and stability is crucial for life; yet, no tissue-driven mechanism that robustly safeguards the epithelial genome has been discovered. Epidermal stem cells (EpiSCs) continuously replenish the stratified layers of …
Cytochrome P45011A1, encoded by Cyp11a1, converts cholesterol to pregnenolone (P5), the first and rate-limiting step in steroidogenesis. In zebrafish, cyp11a1 is maternally expressed and cyp11a2 is considered the ortholog of Cyp11a1 in …
The simultaneous generation of multiple tissues and their functional assembly into complex tissues remains a critical challenge for regenerative medicine. The tissue-to- tissue interface connecting two adjacent tissues is vital in effective tissue function …
Despite various treatment protocols and newly recognized therapeutics, there are no effective treatment approaches against coronavirus disease. New therapeutic strategies including the use of stem cells-derived secretome as a cell-free therapy
Lower back pain is a leading cause of disability and is one of the reasons for the substantial socioeconomic burden. The etiology of intervertebral disc (IVD) degeneration is complicated, and its mechanism is still not completely understood. Fa
Mesenchymal stem cells (MSCs) represent the most clinically used stem cells in regenerative medicine. However, due to the disadvantages with primary MSCs, such as limited cell proliferative capacity and rarity in the tissues leading to limited
Current research data reveal microenvironment as a significant modifier of physical functions, pathologic changes, as well as the therapeutic effects of stem cells. When comparing regeneration potential of various stem cell types used for cytot
BACKGROUNDAs a cellular mode of therapy, bone marrow mesenchymal stem cells (BMSCs) are used to treat stroke. However, their mechanisms in stroke treatment have not been established. Recent evidence suggests that regulation of dysregulated gut
BACKGROUNDIn degenerative intervertebral disc (IVD), an unfavorable IVD environment leads to increased senescence of nucleus pulposus (NP)-derived mesenchymal stem cells (NPMSCs) and the inability to complete the differentiation from NPMSCs to
In the last few decades, stem cell-based therapies have gained attention worldwide for various diseases and disorders. Adult stem cells, particularly mesenchymal stem cells (MSCs), are preferred due to their significant regenerative potential i
BACKGROUNDOne of the most challenging tasks of modern biology concerns the real-time tracking and quantification of mRNA expression in living cells. On this matter, a novel platform called SmartFlareTM has taken advantage of fluorophore-linked
Umakant Yadav
Adam Lauko, Josephine Volovetz, Soumya M Turaga, Defne Bayik, Dennis C Watson, Daniel J Silver, Kelly Mitchell, Erin Mulkearns-Hubert, Kiran Desai, Manav Midha, Jing Hao, Kathleen McCortney, Alicia Steffens, Ulhas Naik, Manmeet S. Ahluwalia, Shideng Bao, Craig Horbinski, Jennifer Yu, Justin D. Lathia
Mingchun Lai, Bin Xi, Shenyu Wei, Wenjin Zhang, ShuSen Zheng
Vitor Hugo Santos, João Pedro Hübbe Pfeifer, Gustavo Dos Santos Rosa, Fernanda De Castro Stievani, Emanuel Vitor Pereira Apolonio, Mariana Correa Rossi, Leonel Vinicius Constantino, Thadeu Rodrigues de Melo, Carlos Eduardo Fonseca-Alves, Ana Liz Garcia Alves
Tingcai Pan, Ning Wang, Jiaye Zhang, Fan Yang, Yan Chen, Yuanqi Zhuang, Yingying Xu, Ji Fang, Kai You, Xianhua Lin, Yang Li, Shao Li, Kangyan Liang, Yin-Xiong Li, Yi Gao
Chronic or non-healing skin wounds present an ongoing challenge in advanced wound care and the ..
Despite the prevalence of traumatic brain injuries (TBIs) and neurodegenerative diseases, there is ..
Despite recent advances in diagnosis and treatment, colorectal cancer (CRC) remains one of the ..
The purpose of this review is to synthesize the existing literature on the intriguing research and ..
Rotator cuff injuries lead to impaired shoulder function, weakness, decreased range of motion, and ..
Rheumatoid Arthritis (RA) is an autoimmune disease that targets the synovial joints of the body ..
Regenerative medicine is an emerging multidisciplinary science that endeavours to replace or ..
Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor, sensory, ..
Myocardial infarction (MI) results in irreversible loss of cardiomyocytes (CMs) and can often lead ..
Cartilage injuries and disease are observed in a varied range of people; for instance, cartilage ..
Objective: This is the first report on the safety and clinical efficacy of a bone marrow ..
Current research in HIV treatment is oriented toward developing a therapeutic that can permanently ..
Northern White Rhinos (NWR) are functionally extinct, with only two females left on the planet. ..
Acute Lymphoblastic Leukemia (ALL) is a cancerous transformation in the blood and bone marrow ..
Hearing loss affects millions of Americans in every age group, and it can be either conductive or ..
In clinical medicine, hematopoietic stem cells have been utilized as a great source for disease ..
Rasmani Hazra, Lily Brine, Libia Garcia, Brian Benz, Napon Chirathivat, Michael M Shen, John Erby Wilkinson, Scott Lyons, David L. Spector
Jorge Zamora-Zaragoza, Katinka Klap, Jaheli Sánchez-Pérez, Jean-Philippe Vielle-Calzada, Ben Scheres
Yu Zhao, Yingzhe Ding, Liangqiang He, Yuying Li, Xiaona Chen, Hao Sun, Huating Wang
Jette Riecks, Balázs Győrffy, Ludwig Kiesel, Alberto Passi, Davide Vigetti, Martin Götte
Pankaj Mogha, Shruti Iyer, Abhijit Majumder
The goal of the current study was to investigate the therapeutic effects of exosomes derived from mesenchymal stem cells (MSCs-Exo) and copper sulfide nanoparticles (CuSNPs) as biomaterials in order to understand the mechanisms that contribute to …
Osteosarcoma is a high-grade bone-forming neoplasm, with a complex genome. Tumours frequently show chromothripsis, many deletions, translocations and copy number alterations. Alterations in the p53 or Rb pathway are the most common …
Rapid percutaneous coronary intervention for acute myocardial infarction (AMI) reduces acute mortality, but there is an urgent need for treatment of left ventricular dysfunction and remodeling after AMI to improve the prognosis. The myocardium …
Human pluripotent stem cells (hPSCs) grow as colonies with epithelial-like features including cell polarity and position-dependent features that contribute to symmetry breaking during development. Our study provides evidence that hPSC colonies …
Mesenchymal stem cells (MSCs) have recently emerged as an important candidate for cell therapy and tissue regeneration. However, some limitations in translational research and therapies still exist, such as insufficient cell supply, inadequate …
Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its …
Titanium is a biomaterial that meets a number of important requirements, including excellent mechanical and chemical properties, but has low bioactivity. To improve cellular response onto titanium surfaces and hence its osseointegration, the titanium …
Hematopoietic stem cell transplantation (HSCT) is an effective treatment method used in many neoplastic and non-neoplastic diseases that affect the bone marrow, blood cells, and immune system. The procedure is associated with a risk of adverse …
Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells that self- renew or differentiate to establish the entire blood hierarchy. HSPCs arise from the hemogenic endothelium of the dorsal aorta (DA) during development in a process …
The uterus is a homeostatic organ, unwavering in the setting of monthly endometrial turnover, placental invasion, and parturition. In response to ovarian steroid hormones, the endometrium autologously prepares for embryo implantation and in …
Differentiation of functional limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) is an important objective which can provide novel treatment solutions for patients suffering from limbal stem ce...
Zahra Khodabandeh, Bahia Namavar Jahromi, Atefe Hashemi, Alireza Afshar, Neda Baghban, Kamran Hessami, Gholamhossein Mohebbi, Alireza Barmak, Iman Jamhiri, Shahrokh Zare, Parmis Badr, Ida Iraji, Tahere Poordast, Arezoo Khoradmehr, Amin Tamadon
Pruritus is a recurring, long-lasting skin disease with few effective treatments. Many patients have unsatisfactory responses to currently available antipruritic treatments, and effective therapeutics are urge...
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