Focus: Hidden - Minnesota

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肾结石是一种常见且痛苦的疾病，许多患者都会经历反复发作。大多数患者在初次排石后想知道未来再次发作的可能性，但这并不容易预测。现在，Mayo Clinic的研究人员通过一个在线预测工具来跟踪肾结石形成者的常见特征，以帮助患者预测未来是否会再次发作。该研究成果发表在 Mayo Clinic Proceedings上。

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People who have chronic inflammation in middle-age may develop problems with thinking and memory in the decades leading up to old age, according to a new study published in the February 13, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Las células madre pluripotentes inducidas son las laboriosas obreras de muchos proyectos de medicina regenerativa y empiezan como células diferenciadas que, a través de la exposición a un complejo conjunto de mezclas genéticas, se reprograman para convertirse en células madre pluripotentes.

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Mayo Clinic的研究人员已经确认，与仅考虑食物的营养构成相比，一种基于个体的遗传、微生物菌群和生活方式的个体化饮食对于控制血液葡萄糖（血糖）水平更加有效。该研究结果发表在2月8日出版的《美国医学会杂志》网络开放版上，研究表明，对于类似的食物，每个人的身体反应有所不同，这是因为每个人都有自己独特的肠道微生物群——一个由上万亿细菌在消化道内形成的复杂群落。

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Numares and Mayo Clinic Laboratories have announced a collaboration to develop clinical diagnostic tests that will measure clusters of risk factors as opposed to individual biomarkers. The unique testing will use nuclear magnetic resonance (NMR) technology, focusing on cardiovascular disease, kidney disease and liver cancer — among a few other specific diseases.

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Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.

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University of Minnesota medical researchers and engineers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3D in vitro model (i.e. in a culture dish rather than in a human or animal).

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Pesquisadores da Mayo Clinic confirmaram que uma dieta individualizada com base na genética, microbioma e estilo de vida de uma pessoa é mais eficaz no controle dos níveis de glicose (açúcar) no sangue do que uma dieta que considera somente a composição nutricional do alimento.

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Una alimentación personalizada y basada tanto en la genética del individuo como en el microbioma y en el estilo de vida es más efectiva para controlar los niveles de la glucosa sanguínea que otra que solamente considera la composición nutricional de los alimentos, confirmaron los investigadores de Mayo Clinic.

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Os cálculos renais são uma condição comum e dolorosa, com muitos pacientes experimentando episódios recorrentes. A maioria das pessoas que passam pelo primeiro cálculo renal quer saber quais são as probabilidades de episódios futuros, mas isso não é sempre fácil de prever.

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An individualized diet based on a person's genetics, microbiome and lifestyle is more effective in controlling blood glucose (sugar) levels than one that considers only nutritional composition of food, Mayo Clinic researchers have confirmed. The research published in the Feb. 8 edition of JAMA Network Open demonstrates that each person's body responds differently to similar foods, due to the unique composition of each person's gut microbiome — the complex community of trillions of bacteria within the digestive track.

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Leidos, a Fortune® 500 science and technology leader, and Mayo Clinic, are announcing a strategic collaboration. This collaboration will build on the combined strengths of both organizations to accelerate the research, development and market adoption of tools, technologies and therapeutics to make patients and their families more active participants in their care, ultimately helping them live happier, healthier lives.

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Previous studies have suggested that having a higher level of education may protect the brain to some extent against dementia, providing a “cognitive reserve” that buffers against the disease. But results have been mixed, and a new study finds that education does not play a role in when the disease starts or how fast it progresses. The study was published in the February 6, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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New computer machine learning techniques can be now be used in crowdsourcing projects to deal with massively increasing amounts of data—making computers a surprising new partner in citizen science projects.

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Los cálculos renales no solo son frecuentes y dolorosos, sino que muchos sufren eventos recurrentes. La mayoría de las personas que pasan el primer cálculo renal desean saber cuál es la probabilidad de tener otro en el futuro, pero eso no siempre es fácil de predecir.

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Kidney stones are a common and painful condition, with many sufferers experiencing recurrent episodes. Most people who pass an initial stone want to know their chances of future episodes, but this has not always been easy to predict. Now Mayo Clinic researchers are tracking the familiar characteristics of kidney stone formers in an online prediction tool that could help sufferers anticipate if they'll experience future episodes. The study was published in Mayo Clinic Proceedings.

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Regular aerobic exercise such as walking, cycling or climbing stairs may improve thinking skills not only in older people but in young people as well, according to a study published in the January 30, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that the positive effect of exercise on thinking skills may increase as people age.

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For people in their 20s and 30s, having blood pressure above normal but below the level considered to be high blood pressure, may be linked to loss of brain volume, according to a study published in the January 23, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.