Researchers have proposed a system for off-label drug prescriptions combining reporting, testing and enforcement regulations, and allowing interim periods of off-label use. This would give patients more treatment options while providing regulators with evidence of the drugs’ safety and efficacy.
Researchers at The Saban Research Institute of Children’s Hospital Los Angeles now reveal an unexpected role for ghrelin in early brain development and show its long-term impact on appetite regulation. Their study will be published online January 20 by The Journal of Clinical Investigation.
In a new study researchers at the UCLA Jonsson Comprehensive Cancer Center have uncovered how melanoma becomes resistant to a promising new drug combo therapy utilizing BRAF+MEK inhibitors in patients after an initial period of tumor shrinkage.
Nobel laureate Martin Chalfie, PhD, will be the keynote speaker at Cedars-Sinai’s Nanomedicine for Imaging and Treatment Conference, where two dozen experts from around the world will discuss emerging trends in the study and treatment of diseases at the molecular and atomic levels.
Pilots receive extensive training on effectively handling emergency situations that may arise in the cockpit. However, during several recent airline incidents, the pilots neglected to apply the skills they learned in training, resulting in fatal crashes. Were these accidents rare exceptions?
The bacteria Vibrio vulnificus, found in warm saltwater, can cause people to get sick, or die, after they eat raw tainted shellfish or when an open wound comes in contact with seawater. A new UCLA study finds out not only why this potentially deadly bacteria is so dangerous in iron overload disease but also discovers that it can be cured.
UCLA transplantation researchers have developed a novel method that more accurately calculates the risk of disease recurrence in liver cancer patients who have undergone a liver transplant, providing a new tool to help physicians make treatment and surveillance decisions.
In a groundbreaking new study, UCLA researchers have discovered that children of melanoma survivors are not adhering optimally to sun protection recommendations. This is concerning as sunburns are a major risk factor for melanoma, and children of survivors are at increased risk for developing the disease as adults.
Why do some people develop post-traumatic stress disorder (PTSD) while others who suffered the same ordeal do not? A new UCLA discovery may shed light on the answer.
A new study by researchers at Children’s Hospital Los Angeles has shown that tissue-engineered small intestine grown from human cells replicates key aspects of a functioning human intestine.
Axel Rosengart, MD, PhD, a prominent neurologist and clinical researcher whose work fostered the creation of medical devices to treat brain-injured patients, has joined Cedars-Sinai in two key neurology posts.
Several new technologies being used in the Cedars-Sinai Neonatal Intensive Care Unit, part of the Maxine Dunitz Children’s Health Center, are helping our smallest babies with more rapid and healthier weight gain. Doctors have begun routinely using a device known as the Pea Pod to measure the body composition of the infants.
UCLA researchers have for the first time developed a method that defines many stages of reprogramming skin or blood cells into pluripotent stem cells. Study analyzed the reprogramming process at the single-cell level on a daily basis. Results determined that stages of cell change were the same across different reprogramming systems and cell types analyzed.
Following is a tip sheet of story ideas from Cedars-Sinai Medical Center. To arrange interviews, please contact the individual listed.Tip sheet topics include organ transplantation, ALS research, sudden cardiac arrest research and more.
A new Kid Captain program will recognize pediatric patients from Mattel Children's Hospital UCLA who face life-threatening illnesses with courage, strength and determination.
About 15 percent of women in the United States suffer from anxiety disorders and depression during their pregnancies, and many are prescribed antidepressants. However little is known about how early exposure to these medications might affect their offspring as they mature into adults.
Children's Hospital Los Angeles infectious diseases specialist Pia Pannaraj, MD, discusses the importance of getting an annual flu vaccine and why opting out should not be an option.
Social media such as Twitter and Facebook, combined with behavioral psychology, could be a valuable tool in the fight against AIDS by prompting high-risk individuals to be tested.
Children’s Hospital Los Angeles (CHLA) announced Monday that Richard D. Cordova, FACHE, president and CEO, intends to retire. The hospital will engage in a national search to identify a successor. Cordova joined CHLA on April 25, 2005 as president and chief operating officer and assumed the role of president and CEO and member of the CHLA Board of Trustees one year later on April 1, 2006.
In a groundbreaking study that offers new hope for women with advanced breast cancer, researchers from UCLA’s Jonsson Comprehensive Cancer Center have published final clinical trial results that showed the amount of time patients were on treatment without their cancer worsening (called progression-free survival) was effectively doubled in women with advanced breast cancer who took the experimental drug palbociclib.
FDA has approved the drug Cyramza, to be used in combination with docetexal for the treatment of non-small-cell lung cancer (NSCLC).
In a groundbreaking new study, UCLA researchers have for the first time advanced a surgical technique performed with the help of a robot to successfully access a previously-unreachable area of the head and neck.
A computer system was more effective than doctors at collecting information about patient symptoms, producing reports that were more complete, organized and useful than narratives generated by physicians during office visits, according to a Cedars-Sinai study.
USC Annenberg’s Health Journalism Fellowships program launches its “Health Matters” webinar series this week, with a provocative online discussion with leading health care thinker Ezekiel Emanuel, M.D.
In results characterized as “very surprising,” UCLA researchers found for the first time that higher-earning clinicians make more money by ordering more procedures and services per patient rather than by seeing more patients, which may not be in patients’ best interest.
Genetics may play a larger role in causing Lou Gehrig’s disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive genetic studies to date of patients who suffer from the condition also known as amyotrophic lateral sclerosis, or ALS.
A study focuses on the fact that the average American receives more than 15 hours a day of digital media, the public's attention span for media and the ways the media is keeping us engaged.
One of medicine’s most prominent experts in sudden cardiac arrest has received a new $2.36 million grant to study how to better predict the deadly heart condition that kills an estimated 300,000 Americans each year.
The nonprofit Children's Hospital Los Angeles has launched the Helping Hands Fund so that it may continue its 113-year mission of providing the highest-quality care to every child it treats, regardless of insurance or ability to pay. Go to www.CHLA.org/HELPINGHANDS
To stop the spread of HIV in Africa, researchers at UCLA, using a complex mathematical model, have developed a strategy that focuses on targeting “hot zones,” areas where the risk of HIV infection is much higher than the national average.
Today in New Delhi, officials of the government of India signed documents establishing the country as a full partner in the Thirty Meter Telescope (TMT) project. An international collaboration of institutions in the USA, Canada, Japan, India and China, the TMT project is working towards building a powerful, next-generation astronomical observatory at Mauna Kea in Hawaii.
Research scientists have developed a novel method to re-create brain and intestinal stem cells from patients who died decades ago, using DNA from stored blood samples to study the potential causes of debilitating illnesses such as inflammatory bowel disease.
In the first study to rigorously address prostate cancer treatment trends by life expectancy in a large, nationally representative sample, UCLA researchers found that more than half of prostate cancer patients 66 years and older have life expectancies of less than10 years, but half of those still were over-treated for their prostate cancer with surgery, radiation or brachytherapy, the implantation of radioactive seeds in the prostate.
In a new study published in Human Factors, researchers studied how the prolonged use of cockpit automation negatively impacts pilots’ ability to remember how to perform key critical thinking tasks.
Bianca Edison, MD, MS is an attending physician in the Children’s Orthopaedic Center at Children’s Hospital Los Angeles. Here she reviews common infant and toddler injuries, and how parents can determine if emergency medical care is needed.
UCLA researchers have pioneered a new methodology to predict why some patients battling advanced melanoma respond well or not at all to the new breakthrough drug pembrolizumab (Keytruda).
The November tip sheet from Cedars-Sinai Medical Center includes story ideas pertaining to ALS Research, Ovarian Cancer, Duchenne Muscular Dystrophy and more.
UCLA scientists have discovered a protein which is integral to the regulation of human blood stem cell regeneration. Study revealed that stem cells which lack the protein have markedly increased ability to replicate in vivo and following transplantation. Discovery provides new understanding of human stem cell self-renewal and paves the way for targeted therapies to make stem cells grow.
After 15 years of educating women about heart disease and providing more than 100,000 free cardiovascular screenings, Sister to Sister: The Women’s Heart Health Foundation founded by Irene Pollin, MSW, announced today that the organization will cease operations on Dec. 31. Pollin also announced that the pioneering organization is donating its educational content and intellectual property to the Barbra Streisand Women’s Heart Center in the Cedars-Sinai Heart Institute.
A new Alzheimer's Prevention Program at Cedars-Sinai in Los Angeles is designed to help identify patients at risk of developing the neurological disorder and to reduce the impact on those diagnosed with the condition. This comprehensive approach eventually may serve as a model that can be implemented elsewhere, with interventions, treatments and care plans built around each patient’s background and interests.
In a randomized clinical trial, 72 percent of participants said that perineal self-acupressure, a simple technique involving the application of external pressure to the perineum — the area between the anus and genitals — helped relieve their constipation
Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis, or ALS, might damage muscle-controlling nerve cells in the brain earlier in the disease process than previously known, according to research from the Cedars-Sinai Board of Governors Regenerative Medicine Institute. The findings, published in the Nov. 12 Journal of Neuroscience, could shift researchers’ attention from the spinal cord to the brain’s motor cortex as the disease’s initial point of dysfunction.
UCLA stem cell researchers cured 18 children born without a working immune system due to life-threatening ADA-deficient Severe Combined Immunodeficiency (SCID). Breakthrough stem cell gene therapy developed by Dr. Donald Kohn and team identifies and corrects faulty gene in children with ADA-deficient SCID using child’s own cells.
Researchers at the Cedars-Sinai Heart Institute have found that injections of cardiac stem cells might help reverse heart damage caused by Duchenne muscular dystrophy, potentially resulting in a longer life expectancy for patients with the chronic muscle-wasting disease.
UCLA/Duke University National Center for Child Traumatic Stress, under a new agreement with the United States Department of Defense, will train behavioral health specialists who work on military bases to provide assistance for military families impacted by child abuse, domestic violence and other forms of child traumatic stress.
The Thirty Meter Telescope (TMT) has launched THINK (The Hawaii Island New Knowledge) Fund to better prepare Hawaii Island students to master STEM (Science, Technology, Engineering and Math) and to become the workforce for higher paying science and technology jobs in Hawaii’s 21st century economy. TMT’s founding gift of $1 million marks the beginning of the construction phase of astronomy’s next-generation telescope on Mauna Kea, Hawaii.
Ronald Reagan UCLA Medical Center has received the American Heart Association’s Get With The Guidelines®–Heart Failure Gold-Plus Quality Achievement Award for implementing specific quality improvement measures outlined by the American Heart Association/American College of Cardiology Foundation guidelines for heart failure patients.
UCLA stem cell scientists discover unique cell surface protein GPI-80 that is key to self-renewal of hematopoietic (blood forming) stem cells (HSCs) during human development. Discovery paves the way for scientists to distinguish HSCs from their short-lived daughter cells and identify the unique properties that enable them to self-renew.
The Voting Design Competition called for submissions that aimed to solve problems in the current voting system through cutting-edge, innovative, interactive user experiences that would redefine the future of voting.
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