Circadian Clock Protein in Kidneys Maintains Homeostasis through Adaptability

Article title: Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels and kidney/adrenal gene expression

Authors: Lauren G. Douma, Hannah M. Costello, G. Ryan Crislip, Kit-Yan Cheng, I. Jeanette Lynch, Alexandria Juffre, Dominique Barral, Sarah Masten, Emilio Roig, Kevin Beguiristain, Wendy Li, Phillip Bratanatawira, Charles S. Wingo, Michelle L. Gumz

From the authors: “These results support the idea that the circadian clock is not only important in maintaining rhythms of physiological functions but is also important for adaptability in response to environmental cues, such as a [high-salt] diet, to maintain overall homeostasis.”

This study is highlighted as one of April’s “best of the best” as part of the American Physiological Society's APSselect program.