Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids

Newswise — Silva et al. describe the differentiation and morphogenesis of human iPSC-derived mesendoderm progenitor aggregates into multilineage organoids under specific culture conditions that persist for >1 year in culture. These organoids demonstrate co-emergence of cardiac and gut tissues. The presence of endodermal tissue promotes atrial/nodal cell-specification and structural/functional maturation of cardiomyocytes.